Simultaneous enhancement in phosphorescence and its lifetime of PtOEP-peptide assembly triggered by protein interaction [전자자료]
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| 100 | 1 | ▼a 강민준 |
| 245 | 1 0 | ▼a Simultaneous enhancement in phosphorescence and its lifetime of PtOEP-peptide assembly triggered by protein interaction ▼h [전자자료] / ▼d Min Joon Kang |
| 246 | 1 1 | ▼a 단백질 상호작용에 의한 PtOEP-펩타이드 조립체의 인광 및 수명의 동시 향상 |
| 260 | ▼a Seoul : ▼b Graduate School, Korea University, ▼c 2023 | |
| 300 | ▼a 전자책 1책(vi, 37 p.) : ▼b 삽화(일부천연색), 도표 | |
| 500 | ▼a 지도교수: 안동준 | |
| 500 | ▼a 본표제는 표제면 이미지의 표제임 | |
| 502 | 0 | ▼a 학위논문(석사)-- ▼b 고려대학교 대학원, ▼c 화공생명공학과, ▼d 2023. 8 |
| 504 | ▼a 참고문헌: p. 32-37 | |
| 653 | ▼a organic light-emitting material ▼a phosphorescence ▼a self-assembly ▼a lifetime enhancement ▼a peptide-protein interaction | |
| 900 | 1 0 | ▼a Kang, Min Joon, ▼e 저 |
| 900 | 1 0 | ▼a 안동준, ▼g 安東俊, ▼d 1963-, ▼e 지도교수 ▼0 AUTH(211009)153384 |
| 945 | ▼a ITMT | |
| 991 | ▼a E-Book(학위논문) ▼w (DCOLL211009)000000277444 |
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| 1 | Simultaneous enhancement in phosphorescence and its lifetime of PtOEP-peptide assembly triggered by protein interaction [전자자료] (4회 열람) |
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Contents information
Abstract
타겟 단백질 상호작용을 나타내며 유기 반도체 물질-펩타이드의 융합 나노입자가 합성됨. 인광 OLED 물질, 플래티넘 옥타에틸포르피린 (PtOEP)은 YCAYYSPRHKTTF 펩타이드 서열의 바이오 리간드, 펩타이드 A17과 재침전법으로 자기조립됨. 조립체는 열충격 단백질70 (HSP70)을 인식함. PtOEP-펩타이드 조립체의 인광강도는 HSP70 처리 후 125% 증가. 단백질에 대한 PtOEP-펩타이드 조립체의 특이적 상호작용은 BSA와 nucleolin과 비교해 용액과 고체 상태에서 확인됨. HSP70에 노출된 PtOEP-펩타이드 조립체의 인광수명은 최초 115 ns에서 153 ns로 크게 증가. PtOEP-펩타이드 조립체는 타겟 단백질과의 상호작용에 의해 인광세기와 수명이 동시에 향상됨. 이는 광발광 소자 분야의 대표적인 물질인 PtOEP의 새로운 응용 가능성을 열어줄 것.
Table of Contents
CHAPTER 1. INTRODUCTION 1 1.1 Organic Semiconducting Phosphor: PtOEP 2 1.2 Bio-Applications of OLED 3 1.3 Peptide Aptamer 4 CHAPTER 2. EXPERIMENTAL SECTION 5 2.1 Materials 5 2.2 Methods 6 2.2.1 Fabrication of PtOEP-A17 Assembly 6 2.2.2 Treatment Conditions of Proteins with PtOEP-A17 Assembly 7 2.3 Measurements 8 2.3.1 Characterization of PtOEP Nanoparticles 8 2.3.2 Time-Resolved Phosphorescence Measurements 10 CHAPTER 3. RESULTS AND DISCUSSION 11 3.1 Photophysical Properties of Fabricated PtOEP Nanoparticles and PtOEP-A17 Assembly 11 3.1.1 Morphological Analysis of PtOEP-A17 Assembly 11 3.1.2 Analysis of Crystal Structure of PtOEP-A17 Assembly 13 3.1.3 Analysis of Photoluminescent Properties of PtOEP-A17 Assembly 15 3.2 Specific Target Recognition of PtOEP-A17 Assembly in the Solution State 19 3.2.1 Distribution Analysis of PtOEP Particles and the Target Protein 19 3.2.2 Phosphorescence Enhancement of PtOEP-A17 Assembly Triggered by Protein Interaction 21 3.2.3 Target Specificity of PtOEP-A17 Assembly 23 3.3 Simultaneous Enhancement in Phosphorescence and Its Lifetime of PtOEP-A17 Assembly Induced by Protein Interaction in the Solid State 25 3.3.1 Photoluminescence Enhancement of PtOEP-A17 Assembly Induced by Protein Interaction 25 3.3.2 Phosphorescence Lifetime Increase of PtOEP-A17 Assembly Induced by Protein Interaction 28 CHAPTER 4. CONCLUSION 31 REFERENCES 32
