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Angiogenesis and anti-angiogenesis in hematological malignancies [electronic resource]

Angiogenesis and anti-angiogenesis in hematological malignancies [electronic resource]

자료유형
E-Book(소장)
개인저자
Ribatti, Domenico, 1956-.
서명 / 저자사항
Angiogenesis and anti-angiogenesis in hematological malignancies [electronic resource] / Domenico Ribatti.
발행사항
Dordrecht :   Springer Netherlands :   Imprint: Springer,   2014.  
형태사항
1 online resource (xi, 114 p.) : ill. (some col.).
ISBN
9789401780353
요약
It has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called “vascular niche”, indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies.
일반주기
Title from e-Book title page.  
내용주기
Preface -- Introduction -- Angiogenesis in multiple myeloma -- Angiogenesis in lymphomas -- Angiogenesis in leukemia -- Antiangiogenesis -- Concluding remarks -- References.
서지주기
Includes bibliographical references and index.
이용가능한 다른형태자료
Issued also as a book.  
일반주제명
Leukemia. Neovascularization. Neovascularization inhibitors --Therapeutic use.
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100 1 ▼a Ribatti, Domenico, ▼d 1956-.
245 1 0 ▼a Angiogenesis and anti-angiogenesis in hematological malignancies ▼h [electronic resource] / ▼c Domenico Ribatti.
260 ▼a Dordrecht : ▼b Springer Netherlands : ▼b Imprint: Springer, ▼c 2014.
300 ▼a 1 online resource (xi, 114 p.) : ▼b ill. (some col.).
336 ▼a text ▼b txt ▼2 rdacontent
337 ▼a computer ▼b c ▼2 rdamedia
338 ▼a online resource ▼b cr ▼2 rdacarrier
500 ▼a Title from e-Book title page.
504 ▼a Includes bibliographical references and index.
505 0 ▼a Preface -- Introduction -- Angiogenesis in multiple myeloma -- Angiogenesis in lymphomas -- Angiogenesis in leukemia -- Antiangiogenesis -- Concluding remarks -- References.
520 ▼a It has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called “vascular niche”, indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies.
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Leukemia.
650 0 ▼a Neovascularization.
650 0 ▼a Neovascularization inhibitors ▼x Therapeutic use.
856 4 0 ▼u https://oca.korea.ac.kr/link.n2s?url=http://dx.doi.org/10.1007/978-94-017-8035-3
945 ▼a KLPA
991 ▼a E-Book(소장)

소장정보

No. 소장처 청구기호 등록번호 도서상태 반납예정일 예약 서비스
No. 1 소장처 중앙도서관/e-Book 컬렉션/ 청구기호 CR 616.994061 등록번호 E14035964 도서상태 대출불가(열람가능) 반납예정일 예약 서비스 M

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