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SCF and APC E3 ubiquitin ligases in tumorigenesis [electronic resource]

SCF and APC E3 ubiquitin ligases in tumorigenesis [electronic resource]

Material type
E-Book(소장)
Personal Author
Inuzuka, Hiroyuki. Wei, Wenyi.
Title Statement
SCF and APC E3 ubiquitin ligases in tumorigenesis [electronic resource] / Hiroyuki Inuzuka, Wenyi Wei.
Publication, Distribution, etc
Cham :   Springer International Publishing :   Imprint: Springer,   2014.  
Physical Medium
1 online resource (v, 118 p.) : col. ill.
Series Statement
Springer briefs in cancer research
ISBN
9783319050263
요약
This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers.
General Note
Title from e-Book title page.  
Content Notes
1. Introduction -- 2. The Fbxw subclass of SCF E3 ubiquitin Ligases -- 3. The FbxL subclass of SCF E3 ubiquitin Ligases -- 4. The Fbxo subclass of SCF E3 ubiquitin Ligases -- 5. APC/Cdc20 and APC/Cdh1 E3 ubiquitin Ligases -- 6. Conclusions and Future Perspectives.
Bibliography, Etc. Note
Includes bibliographical references and index.
이용가능한 다른형태자료
Issued also as a book.  
Subject Added Entry-Topical Term
Carcinogenesis. Ubiquitin. Ligases. Cancer --Pathophysiology. Carcinogenesis. Anaphase-Promoting Complex-Cyclosome --physiology. SKP Cullin F-Box Protein Ligases --physiology.
Short cut
URL
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001 000046047534
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006 m d
007 cr
008 200916s2014 sz a ob 001 0 eng d
020 ▼a 9783319050263
040 ▼a 211009 ▼c 211009 ▼d 211009
050 4 ▼a RC261-271
082 0 0 ▼a 616.99/401 ▼2 23
084 ▼a 616.99401 ▼2 DDCK
090 ▼a 616.99401
100 1 ▼a Inuzuka, Hiroyuki.
245 1 0 ▼a SCF and APC E3 ubiquitin ligases in tumorigenesis ▼h [electronic resource] / ▼c Hiroyuki Inuzuka, Wenyi Wei.
260 ▼a Cham : ▼b Springer International Publishing : ▼b Imprint: Springer, ▼c 2014.
300 ▼a 1 online resource (v, 118 p.) : ▼b col. ill.
490 1 ▼a Springer briefs in cancer research
500 ▼a Title from e-Book title page.
504 ▼a Includes bibliographical references and index.
505 0 ▼a 1. Introduction -- 2. The Fbxw subclass of SCF E3 ubiquitin Ligases -- 3. The FbxL subclass of SCF E3 ubiquitin Ligases -- 4. The Fbxo subclass of SCF E3 ubiquitin Ligases -- 5. APC/Cdc20 and APC/Cdh1 E3 ubiquitin Ligases -- 6. Conclusions and Future Perspectives.
520 ▼a This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers.
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Carcinogenesis.
650 0 ▼a Ubiquitin.
650 0 ▼a Ligases.
650 0 ▼a Cancer ▼x Pathophysiology.
650 1 2 ▼a Carcinogenesis.
650 2 2 ▼a Anaphase-Promoting Complex-Cyclosome ▼x physiology.
650 2 2 ▼a SKP Cullin F-Box Protein Ligases ▼x physiology.
700 1 ▼a Wei, Wenyi.
830 0 ▼a SpringerBriefs in cancer research.
856 4 0 ▼u https://oca.korea.ac.kr/link.n2s?url=http://dx.doi.org/10.1007/978-3-319-05026-3
945 ▼a KLPA
991 ▼a E-Book(소장)

Holdings Information

No. Location Call Number Accession No. Availability Due Date Make a Reservation Service
No. 1 Location Main Library/e-Book Collection/ Call Number CR 616.99401 Accession No. E14033593 Availability Loan can not(reference room) Due Date Make a Reservation Service M

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