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A systems biology approach to blood [electronic resource]

A systems biology approach to blood [electronic resource]

자료유형
E-Book(소장)
개인저자
Corey, Seth J. Kimmel, Marek, 1959-. Leonard, Joshua N.
서명 / 저자사항
A systems biology approach to blood [electronic resource] / Seth J. Corey, Marek Kimmel, Joshua N. Leonard, editors.
발행사항
New York, NY :   Springer New York :   Imprint: Springer,   2014.  
형태사항
1 online resource (ix, 403 p.) : ill. (some col.).
총서사항
Advances in experimental medicine and biology,0065-2598 ; 844
ISBN
9781493920952
요약
The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments result from a highly-ordered process, hematopoiesis. Definitive hematopoiesis occurs in the bone marrow, where pluripotential stem cells give rise to multiple lineages of highly specialized cells. Highly-productive and continuously regenerative, hematopoiesis requires a microenvironment of mesenchymal cells and blood vessels. A Systems Biology Approach to Blood is divided into three main sections: basic components, physiological processes, and clinical applications. Using blood as a window, one can study health and disease through this unique tool box with reactive biological fluids that mirrors the prevailing hemodynamics of the vessel walls and the various blood cell types. Many blood diseases, rare and common can and have been exploited using systems biology approaches with successful results and therefore ideal models for systems medicine. More importantly, hematopoiesis offers one of the best studied systems with insight into stem cell biology, cellular interaction, development; linage programing and reprograming that are every day influenced by the most mature and understood regulatory networks.
일반주기
Title from e-Book title page.  
내용주기
Part I: Basic Components -- Systems Hematology:  An Introduction -- Quantification and Modeling of Stem Cell - Niche Interaction -- Angiogenesis: A Systems Biology View of Blood Vessel Remodeling -- Erythropoiesis: From Molecular Pathways to System Properties -- Systems Biology of Megakaryocytes -- Systems Biology of Platelet-Vessel Wall Interactions -- Systems Approach to Phagoycte Production and Activation: Neutrophils and Monocytes -- Part II: Physiological Processes -- Stochasticity and Determinism in Models of Hematopoiesis -- Systems Analysis of High–Throughput Data -- Developing a Systems-Based Understanding of Hematopoietic Stem Cell Cycle Control -- A Systems Biology Approach to Iron Metabolism -- Innate Immunity in Disease - Insights from Mathematical Modeling and Analysis -- Modeling Biomolecular Site Dynamics in Immunoreceptor Signaling Systems -- Structure and Function of Platelet Receptors Initiating Blood Clotting -- Part III: Clinical Applications -- Understanding and Treating Cytopenia through Mathematical Modeling -- Drug Resistance -- Etiology and Treatment of Hematological Neoplasms: Stochastic Mathematical Models -- Assessing Hematopoietic (Stem-) Cell Behavior during Regenerative Pressure -- Engineered Cell-Based Therapies: A Vanguard of Design-Driven Medicine -- Part IV: Epilogue -- A Systems Approach to Blood Disorders -- Index.
서지주기
Includes bibliographical references and index.
이용가능한 다른형태자료
Issued also as a book.  
일반주제명
Biological models. Hematology. Systems biology.
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URL
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005 20200914113624
006 m d
007 cr
008 200814s2014 nyua ob 001 0 eng d
020 ▼a 9781493920952
040 ▼a 211009 ▼c 211009 ▼d 211009
050 4 ▼a R-RZ
082 0 4 ▼a 612.11 ▼2 23
084 ▼a 612.11 ▼2 DDCK
090 ▼a 612.11
245 0 2 ▼a A systems biology approach to blood ▼h [electronic resource] / ▼c Seth J. Corey, Marek Kimmel, Joshua N. Leonard, editors.
260 ▼a New York, NY : ▼b Springer New York : ▼b Imprint: Springer, ▼c 2014.
300 ▼a 1 online resource (ix, 403 p.) : ▼b ill. (some col.).
490 1 ▼a Advances in experimental medicine and biology, ▼x 0065-2598 ; ▼v 844
500 ▼a Title from e-Book title page.
504 ▼a Includes bibliographical references and index.
505 0 ▼a Part I: Basic Components -- Systems Hematology:  An Introduction -- Quantification and Modeling of Stem Cell - Niche Interaction -- Angiogenesis: A Systems Biology View of Blood Vessel Remodeling -- Erythropoiesis: From Molecular Pathways to System Properties -- Systems Biology of Megakaryocytes -- Systems Biology of Platelet-Vessel Wall Interactions -- Systems Approach to Phagoycte Production and Activation: Neutrophils and Monocytes -- Part II: Physiological Processes -- Stochasticity and Determinism in Models of Hematopoiesis -- Systems Analysis of High–Throughput Data -- Developing a Systems-Based Understanding of Hematopoietic Stem Cell Cycle Control -- A Systems Biology Approach to Iron Metabolism -- Innate Immunity in Disease - Insights from Mathematical Modeling and Analysis -- Modeling Biomolecular Site Dynamics in Immunoreceptor Signaling Systems -- Structure and Function of Platelet Receptors Initiating Blood Clotting -- Part III: Clinical Applications -- Understanding and Treating Cytopenia through Mathematical Modeling -- Drug Resistance -- Etiology and Treatment of Hematological Neoplasms: Stochastic Mathematical Models -- Assessing Hematopoietic (Stem-) Cell Behavior during Regenerative Pressure -- Engineered Cell-Based Therapies: A Vanguard of Design-Driven Medicine -- Part IV: Epilogue -- A Systems Approach to Blood Disorders -- Index.
520 ▼a The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments result from a highly-ordered process, hematopoiesis. Definitive hematopoiesis occurs in the bone marrow, where pluripotential stem cells give rise to multiple lineages of highly specialized cells. Highly-productive and continuously regenerative, hematopoiesis requires a microenvironment of mesenchymal cells and blood vessels. A Systems Biology Approach to Blood is divided into three main sections: basic components, physiological processes, and clinical applications. Using blood as a window, one can study health and disease through this unique tool box with reactive biological fluids that mirrors the prevailing hemodynamics of the vessel walls and the various blood cell types. Many blood diseases, rare and common can and have been exploited using systems biology approaches with successful results and therefore ideal models for systems medicine. More importantly, hematopoiesis offers one of the best studied systems with insight into stem cell biology, cellular interaction, development; linage programing and reprograming that are every day influenced by the most mature and understood regulatory networks.
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Biological models.
650 0 ▼a Hematology.
650 0 ▼a Systems biology.
700 1 ▼a Corey, Seth J.
700 1 ▼a Kimmel, Marek, ▼d 1959-.
700 1 ▼a Leonard, Joshua N.
830 0 ▼a Advances in experimental medicine and biology ; ▼v v. 844.
856 4 0 ▼u https://oca.korea.ac.kr/link.n2s?url=http://dx.doi.org/10.1007/978-1-4939-2095-2
945 ▼a KLPA
991 ▼a E-Book(소장)

소장정보

No. 소장처 청구기호 등록번호 도서상태 반납예정일 예약 서비스
No. 1 소장처 중앙도서관/e-Book 컬렉션/ 청구기호 CR 612.11 등록번호 E14031878 도서상태 대출불가(열람가능) 반납예정일 예약 서비스 M

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