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Tumor metabolome targeting and drug development [electronic resource]

Tumor metabolome targeting and drug development [electronic resource]

자료유형
E-Book(소장)
개인저자
Kanner, Steven.
서명 / 저자사항
Tumor metabolome targeting and drug development [electronic resource] / Steven Kanner, editor.
발행사항
New York, NY :   Springer New York :   Imprint: Springer,   2014.  
형태사항
1 online resource (viii, 198 p.) : ill. (some col.).
총서사항
Cancer drug discovery and development,2196-9906
ISBN
9781461495451
요약
In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism.  The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate.  However, the metabolism of malignant cells generally varies from that of normal cells.  These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options  Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and “reverse” Warburg effect--these topics and more are discussed in this volume.  
일반주기
Title from e-Book title page.  
내용주기
Tumor cell metabolic reprogramming and drug targeting -- Cancer metabolism: a nexus of matter, energy and reactive oxygen species -- Regulating mitochondrial respiration in cancer -- Regulation of cancer cell metabolism by hypoxia -- Glucose metabolism and the anti-oxidative defence system in cancer cells: Options for application of ROS-based anticancer drugs -- Modulating autophagy and the “reverse Warburg effect” -- Metabolic adaptation in reprogrammed cancer cells -- Index.
서지주기
Includes bibliographical references and index.
이용가능한 다른형태자료
Issued also as a book.  
일반주제명
Cell metabolism. Cancer cells --Metabolism. Cancer cells --Growth.
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090 ▼a 616.994061
245 0 0 ▼a Tumor metabolome targeting and drug development ▼h [electronic resource] / ▼c Steven Kanner, editor.
260 ▼a New York, NY : ▼b Springer New York : ▼b Imprint: Springer, ▼c 2014.
300 ▼a 1 online resource (viii, 198 p.) : ▼b ill. (some col.).
490 1 ▼a Cancer drug discovery and development, ▼x 2196-9906
500 ▼a Title from e-Book title page.
504 ▼a Includes bibliographical references and index.
505 0 ▼a Tumor cell metabolic reprogramming and drug targeting -- Cancer metabolism: a nexus of matter, energy and reactive oxygen species -- Regulating mitochondrial respiration in cancer -- Regulation of cancer cell metabolism by hypoxia -- Glucose metabolism and the anti-oxidative defence system in cancer cells: Options for application of ROS-based anticancer drugs -- Modulating autophagy and the “reverse Warburg effect” -- Metabolic adaptation in reprogrammed cancer cells -- Index.
520 ▼a In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism.  The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate.  However, the metabolism of malignant cells generally varies from that of normal cells.  These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options  Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and “reverse” Warburg effect--these topics and more are discussed in this volume.  
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Cell metabolism.
650 0 ▼a Cancer cells ▼x Metabolism.
650 0 ▼a Cancer cells ▼x Growth.
700 1 ▼a Kanner, Steven.
830 0 ▼a Cancer drug discovery and development.
856 4 0 ▼u https://oca.korea.ac.kr/link.n2s?url=http://dx.doi.org/10.1007/978-1-4614-9545-1
945 ▼a KLPA
991 ▼a E-Book(소장)

소장정보

No. 소장처 청구기호 등록번호 도서상태 반납예정일 예약 서비스
No. 1 소장처 중앙도서관/e-Book 컬렉션/ 청구기호 CR 616.994061 등록번호 E14031417 도서상태 대출불가(열람가능) 반납예정일 예약 서비스 M

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