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Chromosomal instability in cancer cells [electronic resource]

Chromosomal instability in cancer cells [electronic resource]

Material type
E-Book(소장)
Personal Author
Ghadimi, B. Michael. Ried, Thomas.
Title Statement
Chromosomal instability in cancer cells [electronic resource] / B. Michael Ghadimi, Thomas Ried, editors.
Publication, Distribution, etc
Cham :   Springer International Publishing :   Imprint: Springer,   2015.  
Physical Medium
1 online resource (vii, 224 p.) : col. ill.
Series Statement
Recent results in cancer research,0080-0015 ; 200
ISBN
9783319202914
요약
This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
General Note
Title from e-Book title page.  
Content Notes
DNA Repair and Chromosomal Translocations -- CINcere modelling: What have mouse models for chromosome instability taught us? -- Telomere Dysfunction, Chromosomal Instability and Cancer -- Genetic Instability and Disease Prognostication -- Causes of Chromosomal Instability -- Patterns of Chromosomal Aberrations in Solid Tumors -- Yeast as Models of Mitotic Fidelity -- The diverse effects of complex chromosome rearrangements and chromothripsis in cancer development -- Consequences of aneuploidy in cancer: transcriptome and beyond.
Bibliography, Etc. Note
Includes bibliographical references.
이용가능한 다른형태자료
Issued also as a book.  
Subject Added Entry-Topical Term
Medicine. Cancer cells. Chromosome abnormalities.
Short cut
URL
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001 000046038171
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006 m d
007 cr
008 200723s2015 sz a ob 000 0 eng d
020 ▼a 9783319202914
040 ▼a 211009 ▼c 211009 ▼d 211009
050 4 ▼a RC254-282
082 0 4 ▼a 616.99/407 ▼2 23
084 ▼a 616.99407 ▼2 DDCK
090 ▼a 616.99407
245 0 0 ▼a Chromosomal instability in cancer cells ▼h [electronic resource] / ▼c B. Michael Ghadimi, Thomas Ried, editors.
260 ▼a Cham : ▼b Springer International Publishing : ▼b Imprint: Springer, ▼c 2015.
300 ▼a 1 online resource (vii, 224 p.) : ▼b col. ill.
490 1 ▼a Recent results in cancer research, ▼x 0080-0015 ; ▼v 200
500 ▼a Title from e-Book title page.
504 ▼a Includes bibliographical references.
505 0 ▼a DNA Repair and Chromosomal Translocations -- CINcere modelling: What have mouse models for chromosome instability taught us? -- Telomere Dysfunction, Chromosomal Instability and Cancer -- Genetic Instability and Disease Prognostication -- Causes of Chromosomal Instability -- Patterns of Chromosomal Aberrations in Solid Tumors -- Yeast as Models of Mitotic Fidelity -- The diverse effects of complex chromosome rearrangements and chromothripsis in cancer development -- Consequences of aneuploidy in cancer: transcriptome and beyond.
520 ▼a This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Medicine.
650 0 ▼a Cancer cells.
650 0 ▼a Chromosome abnormalities.
700 1 ▼a Ghadimi, B. Michael.
700 1 ▼a Ried, Thomas.
830 0 ▼a Recent results in cancer research; ▼v 200.
856 4 0 ▼u https://oca.korea.ac.kr/link.n2s?url=http://dx.doi.org/10.1007/978-3-319-20291-4
945 ▼a KLPA
991 ▼a E-Book(소장)

Holdings Information

No. Location Call Number Accession No. Availability Due Date Make a Reservation Service
No. 1 Location Main Library/e-Book Collection/ Call Number CR 616.99407 Accession No. E14028179 Availability Loan can not(reference room) Due Date Make a Reservation Service M

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