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The neuropathology of Huntington's disease [electronic resource] : classical findings, recent developments and correlation to functional neuroanatomy

The neuropathology of Huntington's disease [electronic resource] : classical findings, recent developments and correlation to functional neuroanatomy

자료유형
E-Book(소장)
개인저자
Rüb, Udo.
서명 / 저자사항
The neuropathology of Huntington's disease [electronic resource] : classical findings, recent developments and correlation to functional neuroanatomy / Udo Rüb ... [et al.].
발행사항
Cham :   Springer International Publishing :   Imprint: Springer,   2015.  
형태사항
1 online resource (xiv, 146 p.) : ill. (some col.), ports.
총서사항
Advances in anatomy, embryology and cell biology,0301-5556 ; 217
ISBN
9783319192857
요약
This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.
일반주기
Title from e-Book title page.  
내용주기
1. Introduction -- 2. The neuropathological grading of Huntington disease -- 3. The cerebral cortex in Huntington´s disease -- 4. Degeneration of select motor and limbic nuclei of the thalamus in Huntington’s disease -- 5. Consistent and widespread degeneration of the cerebellum in Huntington’s disease -- 6. Elucidation of the role of the premotor oculomotor brainstem nuclei in the pathogenesis of oculomotor dysfunctions in Huntington’s disease -- 7. Widespread brainstem neurodegeneration in Huntington’s disease -- 8. Intraneuronal transport and defense mechanisms with possible pathogenetic relevance in Huntington’s disease -- 9. The disease protein huntingtin and neuronal protein aggregations in Huntington’s disease -- 10. Pathological nerve cell alterations in Huntington’s disease (HD) and their possible role for the demise of nerve cells -- 11. Conclusions and outlook.
서지주기
Includes bibliographical references.
이용가능한 다른형태자료
Issued also as a book.  
일반주제명
Huntington's disease. Nervous system --Diseases.
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020 ▼a 9783319192857
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245 0 4 ▼a The neuropathology of Huntington's disease ▼h [electronic resource] : ▼b classical findings, recent developments and correlation to functional neuroanatomy / ▼c Udo Rüb ... [et al.].
260 ▼a Cham : ▼b Springer International Publishing : ▼b Imprint: Springer, ▼c 2015.
300 ▼a 1 online resource (xiv, 146 p.) : ▼b ill. (some col.), ports.
490 1 ▼a Advances in anatomy, embryology and cell biology, ▼x 0301-5556 ; ▼v 217
500 ▼a Title from e-Book title page.
504 ▼a Includes bibliographical references.
505 0 ▼a 1. Introduction -- 2. The neuropathological grading of Huntington disease -- 3. The cerebral cortex in Huntington´s disease -- 4. Degeneration of select motor and limbic nuclei of the thalamus in Huntington’s disease -- 5. Consistent and widespread degeneration of the cerebellum in Huntington’s disease -- 6. Elucidation of the role of the premotor oculomotor brainstem nuclei in the pathogenesis of oculomotor dysfunctions in Huntington’s disease -- 7. Widespread brainstem neurodegeneration in Huntington’s disease -- 8. Intraneuronal transport and defense mechanisms with possible pathogenetic relevance in Huntington’s disease -- 9. The disease protein huntingtin and neuronal protein aggregations in Huntington’s disease -- 10. Pathological nerve cell alterations in Huntington’s disease (HD) and their possible role for the demise of nerve cells -- 11. Conclusions and outlook.
520 ▼a This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Huntington's disease.
650 0 ▼a Nervous system ▼x Diseases.
700 1 ▼a Rüb, Udo.
830 0 ▼a Advances in anatomy, embryology and cell biology ; ▼v 217.
856 4 0 ▼u https://oca.korea.ac.kr/link.n2s?url=http://dx.doi.org/10.1007/978-3-319-19285-7
945 ▼a KLPA
991 ▼a E-Book(소장)

소장정보

No. 소장처 청구기호 등록번호 도서상태 반납예정일 예약 서비스
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