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BRAF targets in melanoma [electronic resource] : biological mechanisms, resistance, and drug discovery

BRAF targets in melanoma [electronic resource] : biological mechanisms, resistance, and drug discovery

Material type
E-Book(소장)
Personal Author
Sullivan, Ryan J.
Title Statement
BRAF targets in melanoma [electronic resource] : biological mechanisms, resistance, and drug discovery / Ryan J. Sullivan, editor.
Publication, Distribution, etc
New York, NY :   Springer New York :   Imprint: Springer,   2015.  
Physical Medium
1 online resource (viii, 204 p.) : ill. (some col.).
Series Statement
Cancer drug discovery and development,2196-9906 ; 82
ISBN
9781493921430
요약
This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that these drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma.
General Note
Title from e-Book title page.  
Content Notes
Melanoma: Historical Context -- Melanoma Pathogenesis -- Molecular Diagnostics and Tumor Mutational Analysis -- Clinical Utility of BRAF-targeted therapy in Melanoma -- The Ethics of Randomized Trials in Oncology -- Parallel and Serial Blockade Strategies in BRAF-Mutant Melanoma -- Targeting the cell cycle and p53 in combination with BRAF-directed therapy -- Combination BRAF-directed therapy and immunotherapy -- Moving Forward: Making BRAF-Targeted Therapy Better.
Bibliography, Etc. Note
Includes bibliographical references and index.
이용가능한 다른형태자료
Issued also as a book.  
Subject Added Entry-Topical Term
Melanoma --Treatment.
Short cut
URL
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001 000046033135
005 20200622150939
006 m d
007 cr
008 200618s2015 nyua ob 001 0 eng d
020 ▼a 9781493921430
040 ▼a 211009 ▼c 211009 ▼d 211009
050 0 0 ▼a RC280.M37
082 0 0 ▼a 616.99/477 ▼2 23
084 ▼a 616.99477 ▼2 DDCK
090 ▼a 616.99477
245 0 0 ▼a BRAF targets in melanoma ▼h [electronic resource] : ▼b biological mechanisms, resistance, and drug discovery / ▼c Ryan J. Sullivan, editor.
260 ▼a New York, NY : ▼b Springer New York : ▼b Imprint: Springer, ▼c 2015.
300 ▼a 1 online resource (viii, 204 p.) : ▼b ill. (some col.).
490 1 ▼a Cancer drug discovery and development, ▼x 2196-9906 ; ▼v 82
500 ▼a Title from e-Book title page.
504 ▼a Includes bibliographical references and index.
505 0 ▼a Melanoma: Historical Context -- Melanoma Pathogenesis -- Molecular Diagnostics and Tumor Mutational Analysis -- Clinical Utility of BRAF-targeted therapy in Melanoma -- The Ethics of Randomized Trials in Oncology -- Parallel and Serial Blockade Strategies in BRAF-Mutant Melanoma -- Targeting the cell cycle and p53 in combination with BRAF-directed therapy -- Combination BRAF-directed therapy and immunotherapy -- Moving Forward: Making BRAF-Targeted Therapy Better.
520 ▼a This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that these drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma.
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Melanoma ▼x Treatment.
700 1 ▼a Sullivan, Ryan J.
830 0 ▼a Cancer drug discovery and development.
856 4 0 ▼u https://oca.korea.ac.kr/link.n2s?url=http://dx.doi.org/10.1007/978-1-4939-2143-0
945 ▼a KLPA
991 ▼a E-Book(소장)

Holdings Information

No. Location Call Number Accession No. Availability Due Date Make a Reservation Service
No. 1 Location Main Library/e-Book Collection/ Call Number CR 616.99477 Accession No. E14025048 Availability Loan can not(reference room) Due Date Make a Reservation Service M

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