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Thyroid hormone disruption and neurodevelopment [electronic resource]

Thyroid hormone disruption and neurodevelopment [electronic resource]

Material type
E-Book(소장)
Personal Author
Koibuchi, Noriyuki. Yen, Paul M.
Title Statement
Thyroid hormone disruption and neurodevelopment [electronic resource] / Noriyuki Koibuchi, Paul M. Yen, editors.
Publication, Distribution, etc
New York, NY :   Springer New York :   Imprint: Springer,   2016.  
Physical Medium
1 online resource (viii, 209 p.) : ill.
Series Statement
Contemporary Clinical Neuroscience
ISBN
9781493937370
요약
Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood. .
General Note
Title from e-Book title page.  
Content Notes
Section 1: Disruption of thyroid hormone action at molecular level -- 1 Molecular mechanisms of thyroid hormone action in brain: a general overview -- 2 Deoidinases and brain development -- 3 Disruption of thyroid hormone receptor-mediated action in brain by endocrine disrupting chemicals -- 4 Chemical disruption of deiodinase activities during pregnancy and fetal neurotoxicity -- 5 Effect of maternal/neonatal infection on thyroid hormone-mediated neurodevelopment -- 6 Disruption of feedback regulation of thyroid hormone synthesis/secretion and brain development -- Section 2: Animal models to study thyroid hormone disruption on neurodevelopment -- 7 Animal models to study thyroid hormone action in neurodevelopment -- 8 Thyroid hormone receptor mutation and neurodevelopment -- 9 Pax6 knockout and cerebellar development -- 10 Disruption of auditory function by thyroid hormone receptor mutation -- Section 3 Thyroid hormone disruption and neurodevelopment: human studies -- 11 Maternal hypothyroidism and brain development of newborns -- 12 Congenital hypothyroidism and neurodevelopment -- 13 Iodine deficiency and brain development -- 14 Deficit in thyroid hormone transporters and brain development -- 15 Syndrome of resistance to thyroid hormone and brain development.
Bibliography, Etc. Note
Includes bibliographical references and index.
이용가능한 다른형태자료
Issued also as a book.  
Subject Added Entry-Topical Term
Thyroid hormones. Thyroid Hormones --metabolism. Endocrine Disruptors --pharmacology. Brain --drug effects. Brain --growth & development. Thyroid Gland --metabolism.
Short cut
URL
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001 000046016894
005 20200304120256
006 m d
007 cr
008 200212s2016 nyua ob 001 0 eng d
020 ▼a 9781493937370
040 ▼a 211009 ▼c 211009 ▼d 211009
050 0 0 ▼a QP572.T5
082 0 0 ▼a 612.4/4 ▼2 23
084 ▼a 612.44 ▼2 DDCK
090 ▼a 612.44
245 0 0 ▼a Thyroid hormone disruption and neurodevelopment ▼h [electronic resource] / ▼c Noriyuki Koibuchi, Paul M. Yen, editors.
260 ▼a New York, NY : ▼b Springer New York : ▼b Imprint: Springer, ▼c 2016.
300 ▼a 1 online resource (viii, 209 p.) : ▼b ill.
490 1 ▼a Contemporary Clinical Neuroscience
500 ▼a Title from e-Book title page.
504 ▼a Includes bibliographical references and index.
505 0 ▼a Section 1: Disruption of thyroid hormone action at molecular level -- 1 Molecular mechanisms of thyroid hormone action in brain: a general overview -- 2 Deoidinases and brain development -- 3 Disruption of thyroid hormone receptor-mediated action in brain by endocrine disrupting chemicals -- 4 Chemical disruption of deiodinase activities during pregnancy and fetal neurotoxicity -- 5 Effect of maternal/neonatal infection on thyroid hormone-mediated neurodevelopment -- 6 Disruption of feedback regulation of thyroid hormone synthesis/secretion and brain development -- Section 2: Animal models to study thyroid hormone disruption on neurodevelopment -- 7 Animal models to study thyroid hormone action in neurodevelopment -- 8 Thyroid hormone receptor mutation and neurodevelopment -- 9 Pax6 knockout and cerebellar development -- 10 Disruption of auditory function by thyroid hormone receptor mutation -- Section 3 Thyroid hormone disruption and neurodevelopment: human studies -- 11 Maternal hypothyroidism and brain development of newborns -- 12 Congenital hypothyroidism and neurodevelopment -- 13 Iodine deficiency and brain development -- 14 Deficit in thyroid hormone transporters and brain development -- 15 Syndrome of resistance to thyroid hormone and brain development.
520 ▼a Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood. .
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Thyroid hormones.
650 1 2 ▼a Thyroid Hormones ▼x metabolism.
650 2 2 ▼a Endocrine Disruptors ▼x pharmacology.
650 2 2 ▼a Brain ▼x drug effects.
650 2 2 ▼a Brain ▼x growth & development.
650 2 2 ▼a Thyroid Gland ▼x metabolism.
700 1 ▼a Koibuchi, Noriyuki.
700 1 ▼a Yen, Paul M.
830 0 ▼a Contemporary Clinical Neuroscience.
856 4 0 ▼u https://oca.korea.ac.kr/link.n2s?url=http://dx.doi.org/10.1007/978-1-4939-3737-0
945 ▼a KLPA
991 ▼a E-Book(소장)

Holdings Information

No. Location Call Number Accession No. Availability Due Date Make a Reservation Service
No. 1 Location Main Library/e-Book Collection/ Call Number CR 612.44 Accession No. E14019750 Availability Loan can not(reference room) Due Date Make a Reservation Service M

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