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Squamous cell carcinoma [electronic resource] : molecular therapeutic targets

Squamous cell carcinoma [electronic resource] : molecular therapeutic targets

Material type
E-Book(소장)
Personal Author
Warnakulasuriya, Saman. Khan, Zakir.
Title Statement
Squamous cell carcinoma [electronic resource] : molecular therapeutic targets / Saman Warnakulasuriya, Zakir Khan, editors.
Publication, Distribution, etc
Dordrecht :   Springer,   2017.  
Physical Medium
1 online resource (xii, 281 p.) : col. ill.
ISBN
9789402410839 9789402410846 (eBook)
요약
This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine. The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer. Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and their therapeutic applications for targeted therapies based on clinical trials reported worldwide. This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.
General Note
Title from e-Book title page.  
Content Notes
Preface -- Foreword.-Introduction- The biology and pathology of squamous cell carcinomata in the head and neck -- Cancer Stem Cells - Biopathology with reference to Head & Neck Cancers -- Hypoxia in head and neck cancer -- Genetic aberrations and molecular pathways in head and neck cancer -- p53 in Head and Neck Squamous Cell Carcinoma -- Blockage of EGFR pathway for anticancer therapy in squamous cell carcinoma of the head and neck -- Targeting the mTOR signaling circuitry in head and neck cancer -- Survivin as a Therapeutic Target in Squamous Cell Carcinoma -- MicroRNA: utility as biomarkers and therapeutic targets in squamous cell carcinoma -- Envoi – An appraisal of Targeted Therapies for Head and Neck Cancer -- Index.
Bibliography, Etc. Note
Includes bibliographical references and index.
이용가능한 다른형태자료
Issued also as a book.  
Subject Added Entry-Topical Term
Squamous cell carcinoma.
Short cut
URL
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020 ▼a 9789402410839
020 ▼a 9789402410846 (eBook)
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090 ▼a 616.99477
245 0 0 ▼a Squamous cell carcinoma ▼h [electronic resource] : ▼b molecular therapeutic targets / ▼c Saman Warnakulasuriya, Zakir Khan, editors.
260 ▼a Dordrecht : ▼b Springer, ▼c 2017.
300 ▼a 1 online resource (xii, 281 p.) : ▼b col. ill.
500 ▼a Title from e-Book title page.
504 ▼a Includes bibliographical references and index.
505 0 ▼a Preface -- Foreword.-Introduction- The biology and pathology of squamous cell carcinomata in the head and neck -- Cancer Stem Cells - Biopathology with reference to Head & Neck Cancers -- Hypoxia in head and neck cancer -- Genetic aberrations and molecular pathways in head and neck cancer -- p53 in Head and Neck Squamous Cell Carcinoma -- Blockage of EGFR pathway for anticancer therapy in squamous cell carcinoma of the head and neck -- Targeting the mTOR signaling circuitry in head and neck cancer -- Survivin as a Therapeutic Target in Squamous Cell Carcinoma -- MicroRNA: utility as biomarkers and therapeutic targets in squamous cell carcinoma -- Envoi – An appraisal of Targeted Therapies for Head and Neck Cancer -- Index.
520 ▼a This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine. The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer. Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and their therapeutic applications for targeted therapies based on clinical trials reported worldwide. This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Squamous cell carcinoma.
700 1 ▼a Warnakulasuriya, Saman.
700 1 ▼a Khan, Zakir.
856 4 0 ▼u https://oca.korea.ac.kr/link.n2s?url=https://doi.org/10.1007/978-94-024-1084-6
945 ▼a KLPA
991 ▼a E-Book(소장)

Holdings Information

No. Location Call Number Accession No. Availability Due Date Make a Reservation Service
No. 1 Location Main Library/e-Book Collection/ Call Number CR 616.99477 Accession No. E14015954 Availability Loan can not(reference room) Due Date Make a Reservation Service M

Contents information

Table of Contents

Preface Foreword Chapter 1. Introduction- The biology and pathology of squamous cell carcinomata in the head and neck Chapter 2 Cancer Stem Cells - Biopathology with reference to Head & Neck Cancers Abstract Chapter 3 Hypoxia in head and neck cancer Chapter 4 Genetic aberrations and molecular pathways in head and neck cancer Chapter 5 p53 in Head and Neck Squamous Cell Carcinoma Chapter 6 Blockage of EGFR pathway for anticancer therapy in squamous cell carcinoma of the head and neck Chapter 7 Targeting the mTOR signaling circuitry in head and neck cancer Abstract Chapter 8 Survivin as a Therapeutic Target in Squamous Cell Carcinoma Chapter 9 MicroRNA: utility as biomarkers and therapeutic targets in squamous cell carcinoma Chapter 10. Envoi - An appraisal of Targeted Therapies for Head and Neck Cancer Index


Information Provided By: : Aladin

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