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Understanding the Gut-Bone signaling axis [electronic resource] : mechanisms and therapeutic implications

Understanding the Gut-Bone signaling axis [electronic resource] : mechanisms and therapeutic implications

자료유형
E-Book(소장)
개인저자
McCabe, Laura R. Parameswaran, Narayanan.
서명 / 저자사항
Understanding the Gut-Bone signaling axis [electronic resource] : mechanisms and therapeutic implications / Laura R. McCabe, Narayanan Parameswaran, editors.
발행사항
Cham :   Springer,   c2017.  
형태사항
1 online resource (xiii, 277 p.) : ill.
총서사항
Advances in Experimental Medicine and Biology,0065-2598 ; 1033
ISBN
9783319666518 9783319666532 (e-book)
요약
This is the first book compiling current research on the gut-bone signaling axis and its implications in the pathophysiology of GI and bone diseases. Rather than focusing on a single mechanism, this book provides the reader with a broad view on gut-bone signaling and the most up-to-date information in this rapidly growing area.  The volume is also unique in that it looks at what is known about GI diseases affecting bone and then examines the role of the microbiome and its modulation by pre and probiotics to treat bone disease, placing this topic within the context of gut-bone signaling pathways. Understanding the Gut-Bone Signaling Axis will thus provide an understanding of how various therapies could be applied to this area.
일반주기
Title from e-Book title page.  
내용주기
Section I: Gut and Bone Physiology -- 1.Introduction -- 2.GI Research: Physiology and Gut Signaling to other organs -- Section II: Gut-Bone Signaling Pathways -- 3. Intestinal regulation of Calcium-Vitamin D and Regulation of Bone Physiology -- 4. GI Regulation of Incretins and Modulation of Bone -- 5.Intestinal Serotonin Regulation of Bone Physiology -- 5. Gut Microbiome and Bone Physiology -- 6. Intestinal Immune System and Regulation of Bone -- Section III: Gut Pathologies Affecting Bone Health -- 7. Stomach-Bone: Gastric Acid and Calcium Absorption -- 8. Inflammatory  Bowel Disease:  Human IBD and Mouse IBD Models -- 9. Antibiotic Use -- 10. Enteritis and Pathogens: Dysbiosis, Pediatrics and Aging -- 11. Enteritis and Pathogens: Chicken Models -- Section IV: Modulation of the Gut Microbiota to Support Bone Health -- 12. Prebiotics -- 13 -- Probiotics -- 14. Germ Free Applications.
서지주기
Includes bibliographical references and index.
이용가능한 다른형태자료
Issued also as a book.  
일반주제명
Gastrointestinal system. Bones. Gastrointestinal system --Microbiology. Gastrointestinal system --Diseases.
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020 ▼a 9783319666518
020 ▼a 9783319666532 (e-book)
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090 ▼a 612.32
245 0 0 ▼a Understanding the Gut-Bone signaling axis ▼h [electronic resource] : ▼b mechanisms and therapeutic implications / ▼c Laura R. McCabe, Narayanan Parameswaran, editors.
260 ▼a Cham : ▼b Springer, ▼c c2017.
300 ▼a 1 online resource (xiii, 277 p.) : ▼b ill.
490 1 ▼a Advances in Experimental Medicine and Biology, ▼x 0065-2598 ; ▼v 1033
500 ▼a Title from e-Book title page.
504 ▼a Includes bibliographical references and index.
505 0 ▼a Section I: Gut and Bone Physiology -- 1.Introduction -- 2.GI Research: Physiology and Gut Signaling to other organs -- Section II: Gut-Bone Signaling Pathways -- 3. Intestinal regulation of Calcium-Vitamin D and Regulation of Bone Physiology -- 4. GI Regulation of Incretins and Modulation of Bone -- 5.Intestinal Serotonin Regulation of Bone Physiology -- 5. Gut Microbiome and Bone Physiology -- 6. Intestinal Immune System and Regulation of Bone -- Section III: Gut Pathologies Affecting Bone Health -- 7. Stomach-Bone: Gastric Acid and Calcium Absorption -- 8. Inflammatory  Bowel Disease:  Human IBD and Mouse IBD Models -- 9. Antibiotic Use -- 10. Enteritis and Pathogens: Dysbiosis, Pediatrics and Aging -- 11. Enteritis and Pathogens: Chicken Models -- Section IV: Modulation of the Gut Microbiota to Support Bone Health -- 12. Prebiotics -- 13 -- Probiotics -- 14. Germ Free Applications.
520 ▼a This is the first book compiling current research on the gut-bone signaling axis and its implications in the pathophysiology of GI and bone diseases. Rather than focusing on a single mechanism, this book provides the reader with a broad view on gut-bone signaling and the most up-to-date information in this rapidly growing area.  The volume is also unique in that it looks at what is known about GI diseases affecting bone and then examines the role of the microbiome and its modulation by pre and probiotics to treat bone disease, placing this topic within the context of gut-bone signaling pathways. Understanding the Gut-Bone Signaling Axis will thus provide an understanding of how various therapies could be applied to this area.
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Gastrointestinal system.
650 0 ▼a Bones.
650 0 ▼a Gastrointestinal system ▼x Microbiology.
650 0 ▼a Gastrointestinal system ▼x Diseases.
700 1 ▼a McCabe, Laura R.
700 1 ▼a Parameswaran, Narayanan.
830 0 ▼a Advances in Experimental Medicine and Biology ; ▼v 1033.
856 4 0 ▼u https://oca.korea.ac.kr/link.n2s?url=https://doi.org/10.1007/978-3-319-66653-2
945 ▼a KLPA
991 ▼a E-Book(소장)

소장정보

No. 소장처 청구기호 등록번호 도서상태 반납예정일 예약 서비스
No. 1 소장처 중앙도서관/e-Book 컬렉션/ 청구기호 CR 612.32 등록번호 E14015223 도서상태 대출불가(열람가능) 반납예정일 예약 서비스 M

컨텐츠정보

목차

Intro -- Contents -- Contributors -- Introduction -- References -- Part I: Gut-Bone Signaling Pathways -- Intestinal Regulation of Calcium: Vitamin D and Bone Physiology -- Introduction -- The Vitamin D Endocrine System: Bioactivation and Mechanism of Action -- Vitamin D and Intestinal Calcium Absorption -- Mechanisms Involved in 1,25(OH)2D3 Regulation of Intestinal Calcium Absorption -- Vitamin D: Direct Effects on Bone -- Vitamin D: The Kidney and Calcium Homeostasis -- Vitamin D: The Intestine and Bone Health -- References -- Intestinal Incretins and the Regulation of Bone Physiology -- Role of Nutrition in Bone Turnover -- Entero-osseous Hormone Processing, Signaling, and Metabolism -- Introduction to Entero-osseous Hormones -- Entero-osseous Hormone Synthesis -- Regulation of Entero-osseous Hormone Secretion -- Entero-osseous Hormone Receptors -- Entero-osseous Hormone Metabolism -- Osseous Effects of GIP, GLP-1, and GLP-2 -- The Entero-osseous Signaling Axis -- Effects of GIP on Bone -- GIP’s Osseous Effects in Aging Populations -- Effects of GLP-1 on Bone -- Effects of GLP-2 on Bone -- Extraosseous Effects of Entero-osseous Hormones -- The Incretin Effect -- Extraosseous GLP-1 Receptors -- Extraosseous GLP-2 Receptors -- Extraosseous GIP Receptors -- Therapeutic Potential of Entero-osseous Hormones -- Diabetic Treatments and EOH-Associated Benefits -- Prospective EOH Therapies -- References -- Regulation of Bone Metabolism by Serotonin -- Introduction -- Serotonin as a Signaling Molecule in the Brain and Periphery -- Serotonin and Bone Remodeling in Health -- Brain-Derived Serotonin -- Gut-Derived Serotonin -- Bone-Derived 5-HT -- Bone Expression of SERT and 5-HT Receptors -- Nonconventional Action of Serotonin in Periphery -- Serotonin and Bone Remodeling in Disease -- Concluding Remarks -- References -- Gut Microbiota and Bone Health -- Introduction -- The Role of Prebiotics and Probiotics in Bone Health -- Microbiome and Bone Health -- Exploring a Potential Brain-Gut-Bone Axis -- Conclusions -- References -- Immunology of Gut-Bone Signaling -- The Digestive Tract -- The Intestinal Immune System -- Paneth Cells -- Goblet Cells -- Intraepithelial Lymphocytes -- Peyer’s Patches -- Solitary Isolated Lymphoid Tissues -- Lamina Propria -- Draining Lymph Nodes -- Inflammatory Intestinal Pathologies -- Osteoimmunology: The Bone Immune System -- Immune Cells and Bone -- T Lymphocyte Regulation of Bone -- CD4+ T Cell Subsets and Their Effects on Bone -- CD8+ T Lymphocyte Regulation of Bone -- CD8+ T Regulatory Cells in Bone Health -- B Lymphocytes and Their Regulation of Bone Cells -- Regulation of Bone by Neutrophils -- Role of Dendritic Cells in Bone Health -- Immune Cytokines and Bone -- TNFα -- Other TNF Superfamily Members -- Interleukin-1 -- Interleukin-6 -- Interleukin-7 -- Interleukin-10 -- Interleukin-17A -- Interferon-γ -- TGFβ -- Immune Involvement and Gut-Bone Signaling in Pathophysiology -- Celiac Disease: Immune System and Bone Resp.

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