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Molecular genetics of endometrial carcinoma [electronic resource]

Molecular genetics of endometrial carcinoma [electronic resource]

자료유형
E-Book(소장)
개인저자
Hedrick Ellenson, Lora.
서명 / 저자사항
Molecular genetics of endometrial carcinoma [electronic resource] / Lora Hedrick Ellenson, editor.
발행사항
Cham :   Springer,   c2017.  
형태사항
1 online resource (xi, 281 p.) : ill.
총서사항
Advances in Experimental Medicine and Biology,0065-2598 ; 943
ISBN
9783319431376 9783319431390 (e-book)
요약
This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.
일반주기
Title from e-Book title page.  
내용주기
Part 1. Introduction -- 1. Epidemiology and metabolic/hormonal influences -- 2. Pathology -- 3. Clinical behavior and treatment -- Part 2. Molecular Profiling -- 4. Traditional approaches -- 5. Next generation sequencing -- 6. Specific Pathways -- Part 3. Mouse models -- 7. Pten -- 8. Mig-6 -- 9. Lkb -- Part 4. 10. Future Directions -- Index.
서지주기
Includes bibliographical references and index.
이용가능한 다른형태자료
Issued also as a book.  
일반주제명
Endometrium --Cancer --Genetic aspects. Endometrial Neoplasms --genetics. Carcinoma --genetics. Signal Transduction.
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020 ▼a 9783319431376
020 ▼a 9783319431390 (e-book)
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082 0 4 ▼a 616.99/466 ▼2 23
084 ▼a 616.99466 ▼2 DDCK
090 ▼a 616.99466
245 0 0 ▼a Molecular genetics of endometrial carcinoma ▼h [electronic resource] / ▼c Lora Hedrick Ellenson, editor.
260 ▼a Cham : ▼b Springer, ▼c c2017.
300 ▼a 1 online resource (xi, 281 p.) : ▼b ill.
490 1 ▼a Advances in Experimental Medicine and Biology, ▼x 0065-2598 ; ▼v 943
500 ▼a Title from e-Book title page.
504 ▼a Includes bibliographical references and index.
505 0 ▼a Part 1. Introduction -- 1. Epidemiology and metabolic/hormonal influences -- 2. Pathology -- 3. Clinical behavior and treatment -- Part 2. Molecular Profiling -- 4. Traditional approaches -- 5. Next generation sequencing -- 6. Specific Pathways -- Part 3. Mouse models -- 7. Pten -- 8. Mig-6 -- 9. Lkb -- Part 4. 10. Future Directions -- Index.
520 ▼a This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Endometrium ▼x Cancer ▼x Genetic aspects.
650 0 ▼a Endometrial Neoplasms ▼x genetics.
650 0 ▼a Carcinoma ▼x genetics.
650 0 ▼a Signal Transduction.
700 1 ▼a Hedrick Ellenson, Lora.
830 0 ▼a Advances in Experimental Medicine and Biology ; ▼v 943.
856 4 0 ▼u https://oca.korea.ac.kr/link.n2s?url=https://doi.org/10.1007/978-3-319-43139-0
945 ▼a KLPA
991 ▼a E-Book(소장)

소장정보

No. 소장처 청구기호 등록번호 도서상태 반납예정일 예약 서비스
No. 1 소장처 중앙도서관/e-Book 컬렉션/ 청구기호 CR 616.99466 등록번호 E14014339 도서상태 대출불가(열람가능) 반납예정일 예약 서비스 M

컨텐츠정보

목차

Part 1. Introduction. Epidemiology of endometrial carcinoma: etiologic importance of hormonal and metabolic influences / Ashley S. Felix, Hannah P. Yang, Daphne W. Bell, and Mark E. Sherman -- Clinical behavior and treatment of endometrial cancer / Divya Gupta -- Pathology of endometrial carcinoma / Sigurd F. Lax -- part 2. Molecular profiling. Traditional approaches to molecular genetic analysis / Christopher J. Walker and Paul J. Goodfellow -- Next-generation sequencing / Matthieu Le Gallo, Fred Lozy, and Daphne W. Bell -- Endometrial carcinoma: specific targeted pathways / Nuria Eritja, Andree Yeramian, Bo-Juen Chen, David Llobet-Navas, Eugenia Ortega, Eva Colas, Miguel Abal, Xavier Dolcet, Jaume Reventos, and Xavier Matias-Guiu -- part 3. Mouse models. LKB1 as a tumor suppressor in uterine cancer: mouse models and translational studies / Christopher G. Peña and Diego H. Castrillón -- Mig-6 mouse model of endometrial cancer / Tae Hoon Kim, Jung-Yoon Yoo, and Jae-Wook Jeong -- PI3K/PTEN/AKT genetic mouse models of endometrial carcinoma / Ayesha Joshi and Lora Hedrick Ellenson.

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