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Drebrin [electronic resource] : from structure and function to physiological and pathological roles

Drebrin [electronic resource] : from structure and function to physiological and pathological roles

Material type
E-Book(소장)
Personal Author
Shirao, Tomoaki. Sekino, Yuko.
Title Statement
Drebrin [electronic resource] : from structure and function to physiological and pathological roles / Tomoaki Shirao, Yuko Sekino, editors.
Publication, Distribution, etc
Tokyo :   Springer,   c2017.  
Physical Medium
1 online resource (xii, 401 p.) : ill. (some col.).
Series Statement
Advances in experimental medicine and biology,0065-2598 ; volume 1006
ISBN
9784431565482 9784431565505 (eBook)
요약
This book is the first comprehensive review of drebrin, which plays pivotal roles in various cellular events, via forming unique actin cytoskeletons, including synapse formation and in synaptic function. Particularly the loss of drebrin from dendritic spines is used as a marker of dementia in neurological disorders such as Alzheimer’s disease. Since drebrin was first identified by our group in 1985, many studies of drebrin have been done in various fields, including not only molecular biology, biophysics, cell biology, neuroscience, clinical studies, spermatogenesis, immunology, and cancer metastasis, but others as well. The structure of this book facilitates the understanding of the whole picture of studies on drebrin. The volume begins with a general introduction to drebrin, and then the chapters in the second part provide the basic knowledge for further understanding. The third part examines its function in the nervous system, and the fourth part discusses its function in the non-nervous system. This work will appeal to researchers who are interested in cytoskeletal dynamics at membrane-cytoskeletal interface as well as the number of them who use drebrin as a tool, such as a marker of synaptic function or a disease marker. This volume is kept as concise as possible in order to be understood by readers in diverse scientific disciplines.
General Note
Title from e-Book title page.  
Content Notes
Preface -- Part 1 History of drebrin discovery as an general introduction -- Chapter1. Introduction -- Part 2 Basic information about drebrin -- Chapter2. Molecular biology of drebrin -- Chapter3. Biochemistry of drebrin and its binding to actin filaments -- Chapter4. Phosphorylation and molecular structure -- Chapter5. Biophysics of drebrin binding actin filament -- Chapter6. Cell shape change by drebrin -- Part 3 Drebrin in Nervous system -- Chapter7. Localization of drebrin in nervous system: LM study -- Chapter8. Localization of drebrin in neurons: EM study -- Chapter9. Drebrin and spine formation -- Chapter10. Activity-dependent change of drebrin localization -- Chapter11. Drebrin in neurogenesis and neuronal migration -- Chapter12. Drebrin in glia -- Part 4 Drebrin in Dementia -- Chapter13. Drebrin in mild cognitive impairment and Alzheimer’s disease -- Chapter14. Amyloid beta and drebrin -- Part 5 Drebrin-binding proteins other than actin filament -- Chapter15. Introduction -- Chapter16. Homer and drebrin -- Chapter17. Spiker mediates drebrin-dependent spine formation -- Part 6 Drebrin in non-nervous system -- Chapter18. Drebrin in immune system -- Chapter19. Drebrin in spermatogenesis -- Chapter20. Drebrin in polarized cells -- Chapter21. Drebrin-dependent stabilization of nectin for maintaining endothelial integrity -- Chapter22. Drebrin in miogenesis -- Part 7 Assorted data relating to drebrin -- Chapter23. Nucleotide and animo acid sequencing of drebrins -- Chapter24. Available antibodies -- Chapter25. Available knockout mice -- Chapter26. How to measure drebrin isoform by ELISA -- Chapter27. Measurement of drebrin accumulation in the spine -- Chapter28. FRAP analysis of drebrin in the spine.
Bibliography, Etc. Note
Includes bibliographical references and index.
이용가능한 다른형태자료
Issued also as a book.  
Subject Added Entry-Topical Term
Neurochemistry. Biochemistry. Cytology. Neurology.
Short cut
URL
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020 ▼a 9784431565482
020 ▼a 9784431565505 (eBook)
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050 4 ▼a QP356.3
082 0 4 ▼a 612.8042 ▼2 23
084 ▼a 612.8042 ▼2 DDCK
090 ▼a 612.8042
245 0 0 ▼a Drebrin ▼h [electronic resource] : ▼b from structure and function to physiological and pathological roles / ▼c Tomoaki Shirao, Yuko Sekino, editors.
260 ▼a Tokyo : ▼b Springer, ▼c c2017.
300 ▼a 1 online resource (xii, 401 p.) : ▼b ill. (some col.).
490 1 ▼a Advances in experimental medicine and biology, ▼x 0065-2598 ; ▼v volume 1006
500 ▼a Title from e-Book title page.
504 ▼a Includes bibliographical references and index.
505 0 ▼a Preface -- Part 1 History of drebrin discovery as an general introduction -- Chapter1. Introduction -- Part 2 Basic information about drebrin -- Chapter2. Molecular biology of drebrin -- Chapter3. Biochemistry of drebrin and its binding to actin filaments -- Chapter4. Phosphorylation and molecular structure -- Chapter5. Biophysics of drebrin binding actin filament -- Chapter6. Cell shape change by drebrin -- Part 3 Drebrin in Nervous system -- Chapter7. Localization of drebrin in nervous system: LM study -- Chapter8. Localization of drebrin in neurons: EM study -- Chapter9. Drebrin and spine formation -- Chapter10. Activity-dependent change of drebrin localization -- Chapter11. Drebrin in neurogenesis and neuronal migration -- Chapter12. Drebrin in glia -- Part 4 Drebrin in Dementia -- Chapter13. Drebrin in mild cognitive impairment and Alzheimer’s disease -- Chapter14. Amyloid beta and drebrin -- Part 5 Drebrin-binding proteins other than actin filament -- Chapter15. Introduction -- Chapter16. Homer and drebrin -- Chapter17. Spiker mediates drebrin-dependent spine formation -- Part 6 Drebrin in non-nervous system -- Chapter18. Drebrin in immune system -- Chapter19. Drebrin in spermatogenesis -- Chapter20. Drebrin in polarized cells -- Chapter21. Drebrin-dependent stabilization of nectin for maintaining endothelial integrity -- Chapter22. Drebrin in miogenesis -- Part 7 Assorted data relating to drebrin -- Chapter23. Nucleotide and animo acid sequencing of drebrins -- Chapter24. Available antibodies -- Chapter25. Available knockout mice -- Chapter26. How to measure drebrin isoform by ELISA -- Chapter27. Measurement of drebrin accumulation in the spine -- Chapter28. FRAP analysis of drebrin in the spine.
520 ▼a This book is the first comprehensive review of drebrin, which plays pivotal roles in various cellular events, via forming unique actin cytoskeletons, including synapse formation and in synaptic function. Particularly the loss of drebrin from dendritic spines is used as a marker of dementia in neurological disorders such as Alzheimer’s disease. Since drebrin was first identified by our group in 1985, many studies of drebrin have been done in various fields, including not only molecular biology, biophysics, cell biology, neuroscience, clinical studies, spermatogenesis, immunology, and cancer metastasis, but others as well. The structure of this book facilitates the understanding of the whole picture of studies on drebrin. The volume begins with a general introduction to drebrin, and then the chapters in the second part provide the basic knowledge for further understanding. The third part examines its function in the nervous system, and the fourth part discusses its function in the non-nervous system. This work will appeal to researchers who are interested in cytoskeletal dynamics at membrane-cytoskeletal interface as well as the number of them who use drebrin as a tool, such as a marker of synaptic function or a disease marker. This volume is kept as concise as possible in order to be understood by readers in diverse scientific disciplines.
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Neurochemistry.
650 0 ▼a Biochemistry.
650 0 ▼a Cytology.
650 0 ▼a Neurology.
700 1 ▼a Shirao, Tomoaki.
700 1 ▼a Sekino, Yuko.
830 0 ▼a Advances in experimental medicine and biology; ▼v v. 1006.
856 4 0 ▼u https://oca.korea.ac.kr/link.n2s?url=https://doi.org/10.1007/978-4-431-56550-5
945 ▼a KLPA
991 ▼a E-Book(소장)

Holdings Information

No. Location Call Number Accession No. Availability Due Date Make a Reservation Service
No. 1 Location Main Library/e-Book Collection/ Call Number CR 612.8042 Accession No. E14013949 Availability Loan can not(reference room) Due Date Make a Reservation Service M

Contents information

Table of Contents

Intro -- Preface -- Contents -- Part I: History of Drebrin Discovery as an General Introduction -- Chapter 1: General Introduction to Drebrin -- 1.1 Introduction -- 1.2 Historical Orientation -- 1.2.1 Background of Drebrin Study -- 1.2.2 Discovery of Drebrin by Proteomics -- 1.2.3 Purification of Drebrin -- 1.2.4 Antibodies Against Drebrin -- 1.2.5 Cloning of DBN1 cDNAs -- 1.2.6 Actin-Binding Activity of Drebrin -- 1.2.7 Drebrin Modifies the Actin Cytoskeleton in Dendritic Spines -- 1.2.8 Advances in Drebrin Studies in the Twenty-First Century -- 1.3 Physiological Roles of Drebrin -- 1.3.1 Morphogenetic Activity of Drebrin -- 1.3.2 Drebrin’s Function in Synaptogenesis -- 1.3.3 Drebrin’s Function in Synaptic Plasticity -- 1.3.4 Drebrin’s Function in Intercellular Communication -- 1.3.5 Drebrin-Decorated F-Actin Can Link to Microtubules -- 1.3.6 Drebrin and Cancer -- 1.4 Perspective and Future Directions -- References -- Part II: Basic Information About Drebrin -- Chapter 2: Molecular Cloning of Drebrin: Progress and Perspectives -- 2.1 Introduction -- 2.2 cDNA Structure of Each Drebrin -- 2.3 Drebrin Isoforms Produced by Alternative Splicing -- 2.4 Protein Family to Which Drebrin Belongs -- 2.5 Conclusions and Perspectives -- References -- Chapter 3: Biochemistry of Drebrin and Its Binding to Actin Filaments -- 3.1 Purification of Drebrin -- 3.2 Actin-Binding and Actin-Bundling Properties of Drebrin -- 3.3 Competitive Binding of Drebrin for F-actin with Other Actin-Binding Proteins -- 3.4 Modulation of Myosin Activity by Drebrin -- 3.5 Conclusion -- References -- Chapter 4: Phosphorylation of Drebrin and Its Role in Neuritogenesis -- 4.1 Breaking Radial Symmetry: Neuritogenesis and the Birth of the Growth Cone -- 4.2 Filopodial Actin Filaments and Dynamic Microtubules Underlie Neuritogenesis -- 4.3 The Drebrin/EB3/Cdk5 Pathway and Neuritogenesis -- 4.4 Drebrin Phosphorylation Regulates Its Interactions with Itself and Other Proteins -- 4.5 In Vivo Experiments with Phospho-mimetic and Phospho-dead S142 -- 4.6 Conclusions and Future Perspectives -- References -- Chapter 5: Remodeling of Actin Filaments by Drebrin A and Its Implications -- 5.1 Introduction and Significance -- 5.2 Actin Structure: Basics and Terminology -- 5.3 Mapping Drebrin-F-Actin Binding Interface -- 5.4 Drebrin Alters the Morphology and Mechanical Properties of Actin Filaments -- 5.5 Cooperativity of Drebrin Binding to F-Actin -- 5.6 Kinetics of Drebrin Binding to F-Actin -- 5.7 Drebrin Effect on Actin Dynamics -- 5.8 Drebrin Effect on the Polymerization-Deficient Actin Forms -- 5.9 Summary and Future Directions -- References -- Chapter 6: Cell Shape Change by Drebrin -- 6.1 Drebrin Distribution in Neurons and in Non-neuronal Cells -- 6.1.1 Distribution in Neurons -- 6.1.2 Distribution in Non-neuronal Cells -- 6.2 Drebrin-Dependent Remodeling of Actin Filaments Within Cells -- 6.3 Drebrin-Dependent Cell Adhesions -- 6.4 Drebrin-Induced Process Formation, Elongation, and Cell Migr.

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