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Cardiac electrophysiology [electronic resource] : from cell to bedside / 6th ed

Cardiac electrophysiology [electronic resource] : from cell to bedside / 6th ed

Material type
E-Book(소장)
Personal Author
Zipes, Douglas P. Jalife, José.
Title Statement
Cardiac electrophysiology [electronic resource] : from cell to bedside / [edited by] Douglas P. Zipes, José Jalife.
판사항
6th ed.
Publication, Distribution, etc
Philadelphia, PA :   Elsevier/Saunders,   c2014.  
Physical Medium
1 online resource (xxvi, 1365 p.) : ill. (some col.) .
기타형태 저록
Print version:   Zipes, Douglas P.   Cardiac electrophysiology.   6th ed.   9781455728565   (211009)000045803508  
ISBN
9781455770106 (electronic bk.) 1455770108 (electronic bk.) 9781455728565 (hardcover ; alk. paper) 145572856X (hardcover ; alk. paper)
요약
Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies. Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world.
General Note
Title from e-Book title page.  
Content Notes
Structural and molecular bases of ion channel function. Voltage-gated sodium channels and electrical excitability of the heart -- Calcium channels in the heart -- Voltage-regulated potassium channels -- Structural and molecular bases of cardiac inward rectifier potassium channel function -- Mammalian calcium pumps in health and disease -- Structural and molecular bases of sarcoplasmic reticulum ion channel function -- Structural and molecular bases of mitochondrial ion channel function -- Molecular organization, gating, and function of gap junction channels -- Biophysics of cardiac ion channel function. Biophysics of normal and abnormal cardiac sodium channel function -- Regulation of cardiac calcium channels -- KCNQ←b1←s/KCNE←b1←s macromolecular signaling complex: channel microdomains and human disease -- Structural determinants and biophysical properties of hERG←b1←s channel gating -- Molecular regulation of cardiac inward rectifier potassium channels by pharmacologic agents -- Cardiac stretch-activated channels and mechano-electric coupling -- Biophysical properties of gap junctions -- Excitation-contraction coupling -- Intermolecular interactions and cardiomyocyte electrical function. Ion channel trafficking in the heart -- Macromolecular complexes and regulation of the sodium channel Nav1.5 -- Calmodulin and CamKII as Ca ←p2←s switches for cardiac ion channels -- Macromolecular complexes and cardiac potassium channels -- Reciprocity of cardiac sodium and potassium channels in the control of excitability and arrhythmias -- The intercalated disc: a molecular network that integrates electrical coupling, intercellular adhesion, and cell excitability -- Scaffolding proteins and ion channel diseases -- Epigenetics in cardiac rhythm diseases -- Cell biology of cardiac impulse initiation and propagation. Cardiac impulse is initiated by a coupled system of membrane ion channels and Ca←p2←s+ cycling proteins -- Biological pacing -- Intercellular communication and impulse propagation -- Mechanisms of atrioventricular nodal excitability and propagation -- Cell biology of the specialized cardiac conduction system -- Cardiac fibroblasts and arrhythmogenesis -- Models of cardiac excitation. Ionic mechanisms of atrial action potentials -- Models of the ventricular action potential in health and disease -- Calcium signaling in cardiomyocyte models with realistic geometries -- Theory of rotors and arrhythmias -- Supraventricular arrhythmias in a realistic 3D model of the human atria -- Cardiac electromechanical models -- Neural control of cardiac electrical activity. CaV1.2 and [beta]-adrenergic regulation of cardiac function -- Cholinergic and constitutive regulation of atrial potassium channel -- Pulmonary vein ganglia and the neural regulation of the heart rate -- Neural activity and atrial tachyarrhythmias -- Sympathetic innervation, denervation, and cardiac arrhythmias -- Arrhythmia mechanisms. Dominant frequency and the mechanisms of initiation and maintenance of atrial fibrillation -- Rotors in human atrial fibrillation -- Atrial ischemia and fibrillation -- The molecular pathophysiology of atrial fibrillation -- Myofibroblasts, cytokines, and persistent atrial fibrillation -- Role of the autonomic nervous system in atrial fibrillation -- Mechanisms of ventricular tachycardia and fibrillation -- Molecular genetics and pharmacogenomics. Genetics of atrial fibrillation -- Mechanisms in heritable sodium channel diseases -- Inheritable potassium channel disease -- Genetics and cellular mechanisms of the J wave syndromes -- Inheritable phenotypes associated with altered intracellular calcium regulation -- Pharmacologic, genetic and cell therapy of ion channel dysfunction. Pharmacologic bases of antiarrhythmic therapy -- Pharmacogenomics of cardiac arrhythmias -- Optogenetic control of heart muscle -- Cell therapy and regenerative electrophysiology -- Diagnostic evaluation. Assessment of the patient with a cardiac arrhythmia -- Differential diagnosis of narrow and wide complex tachycardias -- Mapping and imaging -- CT and MRI for electrophysiology -- Intracardiac echocardiography for electrophysiology -- Exercise-induced arrhythmias -- Cardiac monitoring: short- and long-term recording -- Electrocardiographic imaging in patients with acute coronary syndrome.
Bibliography, Etc. Note
Includes bibliographical references and index.
이용가능한 다른형태자료
Issued also as a book.  
Subject Added Entry-Topical Term
Arrhythmia. Heart --Electric properties. Arrhythmias, Cardiac. Electrophysiologic Techniques, Cardiac. Heart --physiology.
Short cut
ScienceDirect   URL
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084 ▼a 616.128 ▼2 DDCK
090 ▼a 616.128
245 0 0 ▼a Cardiac electrophysiology ▼h [electronic resource] : ▼b from cell to bedside / ▼c [edited by] Douglas P. Zipes, José Jalife.
250 ▼a 6th ed.
260 ▼a Philadelphia, PA : ▼b Elsevier/Saunders, ▼c c2014.
300 ▼a 1 online resource (xxvi, 1365 p.) : ▼b ill. (some col.) .
500 ▼a Title from e-Book title page.
504 ▼a Includes bibliographical references and index.
505 0 ▼a Structural and molecular bases of ion channel function. Voltage-gated sodium channels and electrical excitability of the heart -- Calcium channels in the heart -- Voltage-regulated potassium channels -- Structural and molecular bases of cardiac inward rectifier potassium channel function -- Mammalian calcium pumps in health and disease -- Structural and molecular bases of sarcoplasmic reticulum ion channel function -- Structural and molecular bases of mitochondrial ion channel function -- Molecular organization, gating, and function of gap junction channels -- Biophysics of cardiac ion channel function. Biophysics of normal and abnormal cardiac sodium channel function -- Regulation of cardiac calcium channels -- KCNQ←b1←s/KCNE←b1←s macromolecular signaling complex: channel microdomains and human disease -- Structural determinants and biophysical properties of hERG←b1←s channel gating -- Molecular regulation of cardiac inward rectifier potassium channels by pharmacologic agents -- Cardiac stretch-activated channels and mechano-electric coupling -- Biophysical properties of gap junctions -- Excitation-contraction coupling -- Intermolecular interactions and cardiomyocyte electrical function. Ion channel trafficking in the heart -- Macromolecular complexes and regulation of the sodium channel Nav1.5 -- Calmodulin and CamKII as Ca ←p2←s switches for cardiac ion channels -- Macromolecular complexes and cardiac potassium channels -- Reciprocity of cardiac sodium and potassium channels in the control of excitability and arrhythmias -- The intercalated disc: a molecular network that integrates electrical coupling, intercellular adhesion, and cell excitability -- Scaffolding proteins and ion channel diseases -- Epigenetics in cardiac rhythm diseases -- Cell biology of cardiac impulse initiation and propagation. Cardiac impulse is initiated by a coupled system of membrane ion channels and Ca←p2←s+ cycling proteins -- Biological pacing -- Intercellular communication and impulse propagation -- Mechanisms of atrioventricular nodal excitability and propagation -- Cell biology of the specialized cardiac conduction system -- Cardiac fibroblasts and arrhythmogenesis -- Models of cardiac excitation. Ionic mechanisms of atrial action potentials -- Models of the ventricular action potential in health and disease -- Calcium signaling in cardiomyocyte models with realistic geometries -- Theory of rotors and arrhythmias -- Supraventricular arrhythmias in a realistic 3D model of the human atria -- Cardiac electromechanical models -- Neural control of cardiac electrical activity. CaV1.2 and [beta]-adrenergic regulation of cardiac function -- Cholinergic and constitutive regulation of atrial potassium channel -- Pulmonary vein ganglia and the neural regulation of the heart rate -- Neural activity and atrial tachyarrhythmias -- Sympathetic innervation, denervation, and cardiac arrhythmias -- Arrhythmia mechanisms. Dominant frequency and the mechanisms of initiation and maintenance of atrial fibrillation -- Rotors in human atrial fibrillation -- Atrial ischemia and fibrillation -- The molecular pathophysiology of atrial fibrillation -- Myofibroblasts, cytokines, and persistent atrial fibrillation -- Role of the autonomic nervous system in atrial fibrillation -- Mechanisms of ventricular tachycardia and fibrillation -- Molecular genetics and pharmacogenomics. Genetics of atrial fibrillation -- Mechanisms in heritable sodium channel diseases -- Inheritable potassium channel disease -- Genetics and cellular mechanisms of the J wave syndromes -- Inheritable phenotypes associated with altered intracellular calcium regulation -- Pharmacologic, genetic and cell therapy of ion channel dysfunction. Pharmacologic bases of antiarrhythmic therapy -- Pharmacogenomics of cardiac arrhythmias -- Optogenetic control of heart muscle -- Cell therapy and regenerative electrophysiology -- Diagnostic evaluation. Assessment of the patient with a cardiac arrhythmia -- Differential diagnosis of narrow and wide complex tachycardias -- Mapping and imaging -- CT and MRI for electrophysiology -- Intracardiac echocardiography for electrophysiology -- Exercise-induced arrhythmias -- Cardiac monitoring: short- and long-term recording -- Electrocardiographic imaging in patients with acute coronary syndrome.
505 0 ▼a Head-up tilt table testing -- Autonomic testing and cardiac risk -- Monophasic action potential recording -- T wave alternans -- Noninvasive electrocardiographic imaging of human ventricular arrhythmias and electrophysiological substrate -- Genetic testing -- Supraventricular tachyarrhythmias: mechanisms, clinical features, and management. Sinus node abnormalities -- Atrial tachycardia -- Typical and atypical atrial flutter: mapping and ablation -- Atrial fibrillation: paroxysmal, persistent, and permanent -- Preexcitation, atrioventricular reentry, and variants -- Electrophysiological characteristics of atrioventricular nodal reentrant tachycardia -- Atrial tachyarrhythmias in adults with congenital heart disease -- Junctional tachycardia -- Ventricular tachyarrhythmias: mechanisms, clinical features, and management. Premature ventricular complexes -- Outflow tract ventricular tachyarrhythmias: mechanisms, clinical features, and management -- Fascicular ventricular arrhythmias -- Bundle branch reentry tachycardia -- Ischemic heart disease -- Ventricular tachycardia in patients with dilated cardiomyopathy -- Ventricular arrhythmias in hypertrophic cardiomyopathy -- Ventricular tachycardias in arrhythmogenic right ventricular dysplasia/cardiomyopathy -- VTs in catecholaminergic cardiomyopathy (catecholaminergic polymorphic ventricular tachycardia) -- Ventricular arrhythmias in heart failure -- Ventricular tachycardia in noncompaction cardiomyopathy -- Ventricular arrhythmias in Takotsubo cardiomyopathy -- Brugada syndrome 1992-2012: twenty years of scientific progress -- Long and short QT syndromes -- Andersen-Tawil syndrome -- Timothy syndrome -- J wave syndromes -- Idiopathic ventricular fibrillation -- Sudden infant death syndrome -- Sudden cardiac death in adults -- Arrhythmias in patients with neurologic disorders -- Drug-induced ventricular tachycardia -- Syncope and AV block. Syncope -- Postural orthostatic tachycardia syndrome -- Progressive conduction system disease -- Atrioventricular block -- Arrhythmias in special populations. Sex differences in arrhythmias -- Sudden cardiac deaths in athletes, including commotio cordis -- Arrhythmias in pediatric population -- Sleep-disordered breathing and arrhythmias -- Pharmacologic therapy. Standard antiarrhythmic drugs -- New antiarrhythmic drugs and new concepts for old drugs -- Impact of nontraditional antiarrhythmic drugs on sudden cardiac death -- Prevention of stroke in patients with atrial fibrillation -- Electrical therapy. Implantable cardioverter defibrillators: technical aspects -- Implantable cardioverter defibrillator: clinical aspects -- Implantable pacemakers -- Cardiac resynchronization therapy -- Newer applications of pacemakers -- Catheter ablation: technical aspects -- Catheter ablation: clinical aspects -- Ablation for atrial fibrillation -- Ablation of supraventricular tachyarrhythmias -- Catheter ablation for ventricular tachycardia in patients with structural heart disease -- Special ablation approaches: epicardial, other -- Ablation in pediatrics -- Catheter ablation in congenital heart disease -- Surgery for arrhythmias. Surgery for atrial fibrillation and other SVTs -- Surgery for ventricular arrhythmias -- Vagal stimulation for heart failure -- New approaches. Spinal cord stimulation for heart failure and arrhythmias -- Left atrial occluders/isolation.
520 ▼a Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies. Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world.
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Arrhythmia.
650 0 ▼a Heart ▼x Electric properties.
650 1 2 ▼a Arrhythmias, Cardiac.
650 2 2 ▼a Electrophysiologic Techniques, Cardiac.
650 2 2 ▼a Heart ▼x physiology.
700 1 ▼a Zipes, Douglas P.
700 1 ▼a Jalife, José.
776 0 8 ▼i Print version: ▼a Zipes, Douglas P. ▼t Cardiac electrophysiology. ▼b 6th ed. ▼z 9781455728565 ▼w (211009)000045803508
856 4 0 ▼3 ScienceDirect ▼u https://oca.korea.ac.kr/link.n2s?url=http://www.sciencedirect.com/science/book/9781455728565
945 ▼a KLPA
991 ▼a E-Book(소장)

Holdings Information

No. Location Call Number Accession No. Availability Due Date Make a Reservation Service
No. 1 Location Main Library/e-Book Collection/ Call Number CR 616.128 Accession No. E14013686 Availability Loan can not(reference room) Due Date Make a Reservation Service M

Contents information

Table of Contents

Front cover -- Expert Consult page -- Cardiac Electrophysiology: From Cell to Bedside -- Copyright page -- Contributors -- Preface -- Table of Contents -- Video Contents -- I Structural and Molecular Bases of Ion Channel Function -- 1 Voltage-Gated Sodium Channels and Electrical Excitability of the Heart -- Chapter Outline -- Subunit Structure of Sodium Channels -- Three-Dimensional Structure of Sodium Channels -- Sodium Channel Structure and Function -- Outer Pore and Selectivity Filter -- Voltage-Dependent Activation -- Pore Opening -- Fast Inactivation -- Coupling of Activation to Fast Inactivation -- Slow Inactivation -- Inner Pore and Receptor Site for Local Anesthetic and Antiarrhythmic Drugs -- Sodium Channel Genes -- References -- 2 Calcium Channels in the Heart -- Chapter Outline -- L-type Ca2+ Channels -- Molecular Composition -- Biophysical Properties of ICa,L -- ICa,L Inactivation -- Organization and Localization of LTCCs -- T-type Ca2+ Channels -- Molecular Composition and Biophysical Properties -- Expression Patterns of T-type Ca2+ Channels -- T-type Ca2+ Channels in Pacemaking, Cardiac Conduction, and Heart Disease -- Transient Receptor Potential (TRP) Channels -- General Structure and Biophysical Properties of TRP Channels -- TRPC Channels and Cardiac Hypertrophy -- TRP Channels in Cardiac Fibroblasts -- References -- 3 Voltage-Regulated Potassium Channels -- Chapter Outline -- Summary -- Myocardial Voltage-Gated K+ Channels: Transient Outward Voltage-Gated K+ Channels -- Myocardial Voltage-Gated K+ Channels: Delayed Rectifier Voltage-Gated K+ Channels -- Inwardly Rectifying Myocardial K+ Channels Also Contribute to Repolarization -- Pore-Forming (α) Subunits of Myocardial Voltage-Gated K+ Channels -- Accessory/Auxiliary Subunits of Myocardial Voltage-Gated K+ Channels -- Molecular Determinants of Native Myocardial Transient Outward Voltage-Gated K+ Channels -- Molecular Determinants of Native Myocardial Delayed Rectifier Voltage-Gated K+ Channels -- Molecular Determinants of Myocardial Kir and K2P Channels -- Conclusions -- References -- 4 Structural and Molecular Bases of Cardiac Inward Rectifier Potassium Channel Function -- Chapter Outline -- Background -- A Family of Genes Encode Inward Rectifier Potassium Channels -- Classical Cardiac Inward Rectifier Potassium Channels -- Structure and Function -- Kir2 Subfamily Underlies Cardiac IK1 -- Crystal Structure of Kir2 Channels -- Mechanism of Polyamine-Induced Rectification -- Rectification Properties Are Related to Electrostatic Interactions in the Cytoplasmic Pore of a Kir Channel -- Differential Properties of Kir2.x Subfamily -- Cellular and Membrane Localization -- Pharmacology and Regulation -- Channelopathies -- Acetylcholine-Activated Potassium Channels -- Structure and Function -- Cellular and Membrane Localization -- Pharmacology and Regulation -- Channelopathies -- ATP-Sensitive Potassium Channels -- Structure and Function -- Cellular and Membrane Localization.
-- Pharmacology and Regulation -- Channelopathies -- Conclusion -- References -- 5 Mammalian Calcium Pumps in Health and Disease -- Chapter Outline -- Sarco/Endoplasmic Reticulum Ca2+ ATPase -- Secretory Pathway Ca2+ ATPase -- Plasma Membrane Ca2+ ATPase -- Ca2+ Pumps in the Disease Process -- SERCA Pump -- SPCA Pump -- PMCA Pump -- Conclusions -- Acknowledgments -- References -- 6 Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function -- Chapter Outline -- The Sarcoplasmic Reticulum -- Structural Arrangement of the Sarcoplasmic Reticulum -- Molecular Players of Excitation- Contraction Coupling -- Methods of Recording Sarcoplasmic Reticulum Ion Channels -- Reconstitution of Sarcoplasmic Reticulum Channels in Lipid Bilayers -- Confocal Imaging of RyR Ca2+ Fluxes -- [3H]Ryanodine Binding As an Index of RyR Activity -- Electron Probe X-Ray Microanalysis of Ca2+ and Other Ions Within the Sarcoplasmic Reticulum -- Molecular Structure of the Cardiac Ryanodine Receptor (RyR2) -- Accessory Proteins of the RyR2 Channel -- Ca2+ Regulation of RyR2 Channels -- Regulation of Isolated RyR2 channels -- Regulation of RyR2 Channels In Situ -- Self-Regulation of Sarcoplasmic Reticulum Ca2+ Release -- Modulation of RyR2 Channel Function -- Phosphorylation -- Oxidation and Nitrosylation -- Cytosolic Modulators -- Exogenous Ligands of RyR2 Channels and Drugs That Affect Sarcoplasmic Reticulum Ca2+ Release -- RyR2 Channels in Disease -- Catecholaminergic Polymorphic Ventricular Tachycardia -- Role of RyR2 Channels in Heart Failure -- Monovalent Cation Channels -- Trimeric Intracellular Cation Channel -- Chloride Channels -- References -- 7 Structural and Molecular Bases of Mitochondrial Ion Channel Function -- Chapter Outline -- Historical Overview of Mitochondrial Ion Channel/Transporter Research -- Overview of Mitochondrial Bioenergetics and Mitochondrial Membrane Potential -- Overview of Mitochondrial ROS Generation and Mitochondrial Membrane Potential -- Overview of Mitochondria-Induced Apoptosis and Mitochondrial Ion Channels -- Ion Channels/Transporters at Mitochondrial Inner Membrane -- Mitochondrial Ca2+ Channels/Transporters Regulating Mitochondrial Ca2+ Influx -- Mitochondrial Ca2+ Uniporter (MCU) -- Mitochondrial Ryanodine Receptor (mRyR) -- Letm1 (Ca2+/H+ Antiporter) -- Mitochondrial Ca2+ Channels/Transporters Regulating Mitochondrial Ca2+ Efflux -- Mitochondrial Na+/Ca2+ Exchanger (NCLX) -- Mitochondrial Permeability Transition Pores (mPTP) -- Mitochondrial K+ Channels -- Mitochondrial KATP Channel (mitoKATP) -- Mitochondrial KCa Channel (mitoKCa) -- Proton Fluxes and Uncoupling Proteins -- Anion Channels and Mitochondrial Volume Control -- Ion Channels/Transporters at Mitochondrial Outer Membrane -- Voltage-Dependent Anion Channel (VDAC) -- Apoptosis-Induced Channels -- Mitochondrial Ion Channels/Transporters in Cardiac Function and Dysfunction -- Overview of Mitochondrial Structure and Function in Heart -- Mitochondrial .
Ion Channels/Transporters in Cardiac Excitation-Contraction/Metabolism Coupling and ROS Generation -- Mitochondrial Ion Channels/Transporters in Cardiac Dysfunction: Novel Therapeutic Targets -- Role of Mitochondrial Ion Channels/Transporters in Cardioprotection Against Ischemia-Reperfusion Injury -- Role of Mitochondrial Ion Channels/Transporters in Cardiac Arrhythmias -- Closing Remarks -- References -- 8 Molecular Organization, Gating, and Function of Gap Junction Channels -- Chapter Outline -- Connexins Expression and Oligomerization -- De novo Formation of Gap Junction Channels -- Voltage and Chemical Gating of Connexin-Based Channels -- Hemichannels: Function and Physiologic Relevance -- Connexins Expression Pattern and Propagation of Excitation in the Heart -- Cell-Cell Coupling and Electrical Anisotropy in the Heart -- Passive Electrical Properties of the Sinoatrial Node -- Passive Electrical Properties of the Atrioventricular Node -- Passive Electrical Properties of Conductive and Working Systems of Ventricles and Signal Transfer in P-M Contacts -- Alterations of Cell-Cell Coupling in Cx-Deficient Animals and Disease-Related Mutations -- Acknowledgments -- References -- II Biophysics of Cardiac Ion Channel Function -- 9 Biophysics of Normal and Abnormal Cardiac Sodium Channel Function -- Abstract -- Chapter Outline -- Nav Channel Activity in Health and Disease -- NaV Channel Trafficking and Stabilization in Health and Disease -- Nav Channel Posttranslational Regulation in Health and Disease -- Summary and Future Directions -- Acknowledgments -- References -- 10 Regulation of Cardiac Calcium Channels -- Chapter Outline -- Overview -- Calcium Channel Expression in the Myocardium -- L-type versus T-type Channel Expression and Gating -- The Cardiac L-type Calcium Channel Is a Multiprotein Complex -- CaV1.2 Structure and Gating -- Voltage Effects on Activation and Inactivation -- Activation -- Inactivation -- Calcium Regulates Activation and Inactivation Gating -- Posttranslational Modification Effects on Ca-Channel Gating -- β-Adrenergic–Modulated Ca-Channel Gating -- Facilitation -- Other Protein Interactions Affecting L-Type Ca2+–Channel Gating -- RGK Proteins -- Calcineurin -- CaV1.2-Coupled Gating -- N-Terminal–C-Terminal Interaction -- References -- 11 KCNQ1/KCNE1 Macromolecular Signaling Complex: -- Chapter Outline -- β-AR Signaling: Coordination of Localized Regulation of Channel Proteins by A-Kinase Anchoring Proteins -- Role of Leucine Zipper in Protein-Protein Interaction -- Molecular Components of the Iks/AKAP9 Complex -- Iks Channel Regulation and Human Diseases -- KCNQ1 G589D and LQT-1 -- KCNE1 D76N Mutation and LQT-5 -- AKAP9 S1570L Mutation and LQT-11 -- IKs Channel and Atrial Fibrillation -- Using Stem Cells as a New Tool to Study Role of Iks Channels in Diseases -- Summary -- References -- 12 Structural Determinants and Biophysical Properties of hERG1 Channel Gating -- Chapter Outline -- Background -- Biophysi.

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