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Application of systematic review methods in an overall strategy for evaluating low-dose toxicity from endocrine active chemicals [electronic resource]

Application of systematic review methods in an overall strategy for evaluating low-dose toxicity from endocrine active chemicals [electronic resource]

자료유형
E-Book(소장)
단체저자명
National Academies of Sciences, Engineering, and Medicine (U.S.). Committee on Endocrine-Related Low-Dose Toxicity.
서명 / 저자사항
Application of systematic review methods in an overall strategy for evaluating low-dose toxicity from endocrine active chemicals [electronic resource] / Committee on Endocrine-Related Low-Dose Toxicity, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies.
발행사항
Washington, DC :   National Academies Press,   c2017.  
형태사항
1 online resource : ill.
ISBN
9780309458634 (electronic bk.) 0309458633 (electronic bk.) 9780309458627 0309458625
요약
"To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects"--Publisher's description.
일반주기
Title from e-Book title page.  
"A consensus study report of the National Academies of Sciences, Engineering, Medicine."  
내용주기
Introduction -- Strategy for evaluating low-dose effects -- Phthalates and male reproductive-tract development -- Effect of polybrominated diphenyl ethers on neurodevelopment -- Lessons learned and reflections on the statement of task -- Appendix A: Biosketches of the Committee on Endocrine-Related Low-Dose Toxicity -- Appendix B; Workshop on Potential Case Studies for Unraveling Endocrine-Related Low-Dose Toxicity -- Appendix C: Supporting materials for the phthalate (animal) systematic review -- Appendix D: Supporting materials for the phthalate (human) systematic review -- Appendix E: Supporting materials for the PBDE (animal) systematic review -- Appendix F: Supporting materials for the PBDE (human) systematic review.
서지주기
Includes bibliographical references.
이용가능한 다른형태자료
Issued also as a book.  
일반주제명
Endocrine toxicology --Congresses. Endocrine disrupting chemicals --Toxicity testing --Congresses. Systematic reviews (Medical research) --Congresses. Endocrine Glands.
바로가기
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245 0 0 ▼a Application of systematic review methods in an overall strategy for evaluating low-dose toxicity from endocrine active chemicals ▼h [electronic resource] / ▼c Committee on Endocrine-Related Low-Dose Toxicity, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies.
260 ▼a Washington, DC : ▼b National Academies Press, ▼c c2017.
300 ▼a 1 online resource : ▼b ill.
500 ▼a Title from e-Book title page.
500 ▼a "A consensus study report of the National Academies of Sciences, Engineering, Medicine."
504 ▼a Includes bibliographical references.
505 0 ▼a Introduction -- Strategy for evaluating low-dose effects -- Phthalates and male reproductive-tract development -- Effect of polybrominated diphenyl ethers on neurodevelopment -- Lessons learned and reflections on the statement of task -- Appendix A: Biosketches of the Committee on Endocrine-Related Low-Dose Toxicity -- Appendix B; Workshop on Potential Case Studies for Unraveling Endocrine-Related Low-Dose Toxicity -- Appendix C: Supporting materials for the phthalate (animal) systematic review -- Appendix D: Supporting materials for the phthalate (human) systematic review -- Appendix E: Supporting materials for the PBDE (animal) systematic review -- Appendix F: Supporting materials for the PBDE (human) systematic review.
520 1 ▼a "To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects"--Publisher's description.
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Endocrine toxicology ▼v Congresses.
650 0 ▼a Endocrine disrupting chemicals ▼x Toxicity testing ▼v Congresses.
650 0 ▼a Systematic reviews (Medical research) ▼v Congresses.
650 2 ▼a Endocrine Glands.
710 2 ▼a National Academies of Sciences, Engineering, and Medicine (U.S.). ▼b Committee on Endocrine-Related Low-Dose Toxicity.
711 2 ▼a Workshop on Potential Case Studies for Unraveling Endocrine-Related Low-Dose Toxicity ▼d (2016 : ▼c Washington, D.C.).
856 4 0 ▼3 EBSCOhost ▼u https://oca.korea.ac.kr/link.n2s?url=http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=1568471
945 ▼a KLPA
991 ▼a E-Book(소장)

소장정보

No. 소장처 청구기호 등록번호 도서상태 반납예정일 예약 서비스
No. 1 소장처 중앙도서관/e-Book 컬렉션/ 청구기호 CR 616.4071 등록번호 E14012197 도서상태 대출불가(열람가능) 반납예정일 예약 서비스 M

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