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Teratogenicity testing : methods and protocols

Teratogenicity testing : methods and protocols

자료유형
단행본
개인저자
Félix, Luís.
서명 / 저자사항
Teratogenicity testing : methods and protocols / edited by Luís Félix.
발행사항
New York, NY :   Humana Press :   Springer,   2018.  
형태사항
xv, 614 p. : ill. (some col.) ; 27 cm.
총서사항
Methods in molecular biology,1064-3745 ; 1797
ISBN
1493978829 9781493978823
요약
This detailed book provides a compilation of laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. After an introduction to teratogenicity testing, the contents explore both in vitro and in vivo techniques in the study of the teratogenic and fetotoxic effects of drugs, as well as numerous animal-based teratology methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Teratogenicity Testing: Methods and Protocols describes methods that integrate a battery of tests that can be performed in cells, organs, tissues, and animal models for evaluating toxicity and/or the safety of compounds in early developmental stages with the goal of estimating, preventing, or minimizing the teratogenic potential of drugs.
내용주기
An Overview of Teratology -- Teratology Study Guidelines: An Overview -- Biological Concerns on the Selection of Animal Models for Teratogenic Testing -- The Validated Embryonic Stem Cell Test with Murine Embryonic Stem Cells -- Human Pluripotent Stem Cells to Assess Developmental Toxicity in the Osteogenic Lineage -- Chick Embryonic Cardiomyocytes Micromass System for Assessing Developmental Cardiotoxicity of Drugs -- Flow Cytometry to Evaluate Potential Developmental Toxicants in the Embryonic Stem Cell -- Morphology-Based Whole Embryo Culture for Developmental Toxicity of Drugs -- Western Blot Methodologies for Analysis of In Vitro Protein Expression Induced by Teratogenic Agents -- Manipulation of MicroRNAs in Cultured Mouse Embryos: Applications for Developmental Toxicology -- Insights into the Phenotypic and Behavioral Effects of Teratogenic Drugs in Caenorhabditis elegans -- Effect of Teratogens on Development of Drosophila melanogaster -- Cellular Responses in Drosophila melanogaster Following Teratogen Exposure -- Behavioral Teratogenesis in Drosophila melanogaster -- Evaluation of the Teratogenicity of Pharmaceuticals Using FETAX -- Histological Observation of Teratogenic Phenotypes Induced in Frog Embryo Assays -- Visualization of Gene Expression Patterns by In Situ Hybridization on Early Stages of Development of Xenopus laevis -- Analysis of Lethality and Malformations During Zebrafish (Danio rerio) Development -- General Whole-Mount Immunohistochemistry of Zebrafish (Danio rerio) Embryos and Larvae Protocol -- Geometric Morphometrics as a Tool to Evaluate Teratogenic Effects in Zebrafish (Danio rerio) -- Live Metabolic Profile Analysis of Zebrafish Embryos Using a Seahorse XF 24 Extracellular Flux Analyzer -- Behavioral Profiling of Zebrafish (Danio rerio) Larvae Following Teratogen Exposure -- Omics in Zebrafish Teratogenesis -- Proteomic Analysis of Zebrafish (Danio rerio) after Chemical Exposure -- Immunohistochemical Assessment as a Tool for Investigating Developmental Toxicity in Zebrafish (Danio rerio) -- Oxidative Stress Assessment in Zebrafish Larvae -- Hemodynamic Studies for Analyzing the Teratogenic Effects of Drugs in the Zebrafish Embryo -- Western Blot Analysis and Immunostaining for Prediction of Embryotoxicity in Mus musculus -- Histological and Histochemical Profile for Teratological Assessment in Mus musculus -- In Vivo Analysis of Apoptosis in Embryonic Hippocampus -- Measurement of Mitochondrial Toxicity Parameters in Embryonic Hippocampus -- Animal Tests for Evaluation of Cognitive Impairment in Neonatal Mouse -- Methodology of Genotoxic and Teratogenic Studies in Rats -- Whole Mount In Situ Hybridization and Morphometric Analysis in Rabbit Embryos -- Glossary of Key Terms for Teratology.
서지주기
Includes bibliographical references and index.
일반주제명
Teratogenicity testing --Laboratory manuals. Pharmacology. Medicine.
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245 0 0 ▼a Teratogenicity testing : ▼b methods and protocols / ▼c edited by Luís Félix.
260 ▼a New York, NY : ▼b Humana Press : ▼b Springer, ▼c 2018.
300 ▼a xv, 614 p. : ▼b ill. (some col.) ; ▼c 27 cm.
490 1 ▼a Methods in molecular biology, ▼x 1064-3745 ; ▼v 1797
490 1 ▼a Springer protocols, ▼x 1949-2448
504 ▼a Includes bibliographical references and index.
505 0 ▼a An Overview of Teratology -- Teratology Study Guidelines: An Overview -- Biological Concerns on the Selection of Animal Models for Teratogenic Testing -- The Validated Embryonic Stem Cell Test with Murine Embryonic Stem Cells -- Human Pluripotent Stem Cells to Assess Developmental Toxicity in the Osteogenic Lineage -- Chick Embryonic Cardiomyocytes Micromass System for Assessing Developmental Cardiotoxicity of Drugs -- Flow Cytometry to Evaluate Potential Developmental Toxicants in the Embryonic Stem Cell -- Morphology-Based Whole Embryo Culture for Developmental Toxicity of Drugs -- Western Blot Methodologies for Analysis of In Vitro Protein Expression Induced by Teratogenic Agents -- Manipulation of MicroRNAs in Cultured Mouse Embryos: Applications for Developmental Toxicology -- Insights into the Phenotypic and Behavioral Effects of Teratogenic Drugs in Caenorhabditis elegans -- Effect of Teratogens on Development of Drosophila melanogaster -- Cellular Responses in Drosophila melanogaster Following Teratogen Exposure -- Behavioral Teratogenesis in Drosophila melanogaster -- Evaluation of the Teratogenicity of Pharmaceuticals Using FETAX -- Histological Observation of Teratogenic Phenotypes Induced in Frog Embryo Assays -- Visualization of Gene Expression Patterns by In Situ Hybridization on Early Stages of Development of Xenopus laevis -- Analysis of Lethality and Malformations During Zebrafish (Danio rerio) Development -- General Whole-Mount Immunohistochemistry of Zebrafish (Danio rerio) Embryos and Larvae Protocol -- Geometric Morphometrics as a Tool to Evaluate Teratogenic Effects in Zebrafish (Danio rerio) -- Live Metabolic Profile Analysis of Zebrafish Embryos Using a Seahorse XF 24 Extracellular Flux Analyzer -- Behavioral Profiling of Zebrafish (Danio rerio) Larvae Following Teratogen Exposure -- Omics in Zebrafish Teratogenesis -- Proteomic Analysis of Zebrafish (Danio rerio) after Chemical Exposure -- Immunohistochemical Assessment as a Tool for Investigating Developmental Toxicity in Zebrafish (Danio rerio) -- Oxidative Stress Assessment in Zebrafish Larvae -- Hemodynamic Studies for Analyzing the Teratogenic Effects of Drugs in the Zebrafish Embryo -- Western Blot Analysis and Immunostaining for Prediction of Embryotoxicity in Mus musculus -- Histological and Histochemical Profile for Teratological Assessment in Mus musculus -- In Vivo Analysis of Apoptosis in Embryonic Hippocampus -- Measurement of Mitochondrial Toxicity Parameters in Embryonic Hippocampus -- Animal Tests for Evaluation of Cognitive Impairment in Neonatal Mouse -- Methodology of Genotoxic and Teratogenic Studies in Rats -- Whole Mount In Situ Hybridization and Morphometric Analysis in Rabbit Embryos -- Glossary of Key Terms for Teratology.
520 ▼a This detailed book provides a compilation of laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. After an introduction to teratogenicity testing, the contents explore both in vitro and in vivo techniques in the study of the teratogenic and fetotoxic effects of drugs, as well as numerous animal-based teratology methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Teratogenicity Testing: Methods and Protocols describes methods that integrate a battery of tests that can be performed in cells, organs, tissues, and animal models for evaluating toxicity and/or the safety of compounds in early developmental stages with the goal of estimating, preventing, or minimizing the teratogenic potential of drugs.
650 0 ▼a Teratogenicity testing ▼v Laboratory manuals.
650 0 ▼a Pharmacology.
650 0 ▼a Medicine.
700 1 ▼a Félix, Luís.
830 0 ▼a Methods in molecular biology ; ▼v 1797.
830 0 ▼a Springer protocols (Series).
945 ▼a KLPA

소장정보

No. 소장처 청구기호 등록번호 도서상태 반납예정일 예약 서비스
No. 1 소장처 과학도서관/Sci-Info(2층서고)/ 청구기호 618.32 T3152 등록번호 121245889 도서상태 대출가능 반납예정일 예약 서비스 B M

컨텐츠정보

목차

An Overview of Teratology
Teratology Study Guidelines: An Overview
Biological Concerns on the Selection of Animal Models for Teratogenic Testing
The Validated Embryonic Stem Cell Test with Murine Embryonic Stem Cells
Human Pluripotent Stem Cells to Assess Developmental Toxicity in the Osteogenic Lineage
Chick Embryonic Cardiomyocytes Micromass System for Assessing Developmental Cardiotoxicity of Drugs
Flow Cytometry to Evaluate Potential Developmental Toxicants in the Embryonic Stem Cell
Morphology-Based Whole Embryo Culture for Developmental Toxicity of Drugs
Western Blot Methodologies for Analysis of In Vitro Protein Expression Induced by Teratogenic Agents
Manipulation of MicroRNAs in Cultured Mouse Embryos: Applications for Developmental Toxicology
Insights into the Phenotypic and Behavioral Effects of Teratogenic Drugs in Caenorhabditis elegans
Effect of Teratogens on Development of Drosophila melanogaster
Cellular Responses in Drosophila melanogaster Following Teratogen Exposure
Behavioral Teratogenesis in Drosophila melanogaster
Evaluation of the Teratogenicity of Pharmaceuticals Using FETAX
Histological Observation of Teratogenic Phenotypes Induced in Frog Embryo Assays
Visualization of Gene Expression Patterns by In Situ Hybridization on Early Stages of Development of Xenopus laevis
Analysis of Lethality and Malformations During Zebrafish (Danio rerio) Development
General Whole-Mount Immunohistochemistry of Zebrafish (Danio rerio) Embryos and Larvae Protocol
Geometric Morphometrics as a Tool to Evaluate Teratogenic Effects in Zebrafish (Danio rerio)
Live Metabolic Profile Analysis of Zebrafish Embryos Using a Seahorse XF 24 Extracellular Flux Analyzer
Behavioral Profiling of Zebrafish (Danio rerio) Larvae Following Teratogen Exposure
Omics in Zebrafish Teratogenesis
Proteomic Analysis of Zebrafish (Danio rerio) after Chemical Exposure
Immunohistochemical Assessment as a Tool for Investigating Developmental Toxicity in Zebrafish (Danio rerio)
Oxidative Stress Assessment in Zebrafish Larvae
Hemodynamic Studies for Analyzing the Teratogenic Effects of Drugs in the Zebrafish Embryo
Western Blot Analysis and Immunostaining for Prediction of Embryotoxicity in Mus musculus
Histological and Histochemical Profile for Teratological Assessment in Mus musculus
In Vivo Analysis of Apoptosis in Embryonic Hippocampus
Measurement of Mitochondrial Toxicity Parameters in Embryonic Hippocampus
Animal Tests for Evaluation of Cognitive Impairment in Neonatal Mouse
Methodology of Genotoxic and Teratogenic Studies in Rats
Whole Mount In Situ Hybridization and Morphometric Analysis in Rabbit Embryos
Glossary of Key Terms for Teratology.

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