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Drug design and discovery in Alzheimer's disease [electronic resource]

Drug design and discovery in Alzheimer's disease [electronic resource]

자료유형
E-Book(소장)
개인저자
Rahman, Atta-ur-, 1942-. Choudhary, Muhammad Iqbal.
서명 / 저자사항
Drug design and discovery in Alzheimer's disease [electronic resource] / edited by Att-ur-Rahman, FRS, Honorary Life Fellow, Kings College, University of Cambridge, UK and Muhammad Iqbal Choudhary, H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.
발행사항
Amsterdam, Netherlands :   Elsevier,   2014.  
형태사항
1 online resource (xviii, 766 p.) : ill. (some col.).
ISBN
9780128039601 (electronic bk.) 0128039604 (electronic bk.) 9780128039595 (electronic bk.) 0128039590 (electronic bk.)
요약
Drug Design and Discovery in Alzheimer's Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an.
일반주기
Title from e-Book title page.  
내용주기
Front Cover; Drug Design and Discovery in Alzheimer's Disease; Copyright; Contents; Preface; List of Contributors; Chapter 1: Pharmacotherapy of Alzheimer's Disease: Current State and Future Perspectives; Abstract; 1. Alzheimer's Disease -- Historic Overview; 2. Current Status and Prevalence of AD; 3. Risk Factors for AD; 4. Cholinergic Theory; 5. Cholinesterases; 6. Current Therapeutic Approaches to AD; 7. Conclusions; Acknowledgements; Conflict of Interest; References; Chapter 2: Challenges in Designing Therapeutic Agents for Treatingalzheimer's Disease-From Serendipity to Rationality.
서지주기
Includes bibliographical references and index.
이용가능한 다른형태자료
Issued also as a book.  
일반주제명
Alzheimer's disease --Chemotherapy. Alzheimer's disease --Treatment. Drugs --Design. Alzheimer Disease --drug therapy. Drug Delivery Systems.
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ScienceDirect   URL
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245 0 0 ▼a Drug design and discovery in Alzheimer's disease ▼h [electronic resource] / ▼c edited by Att-ur-Rahman, FRS, Honorary Life Fellow, Kings College, University of Cambridge, UK and Muhammad Iqbal Choudhary, H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.
260 ▼a Amsterdam, Netherlands : ▼b Elsevier, ▼c 2014.
300 ▼a 1 online resource (xviii, 766 p.) : ▼b ill. (some col.).
500 ▼a Title from e-Book title page.
504 ▼a Includes bibliographical references and index.
505 0 ▼a Front Cover; Drug Design and Discovery in Alzheimer's Disease; Copyright; Contents; Preface; List of Contributors; Chapter 1: Pharmacotherapy of Alzheimer's Disease: Current State and Future Perspectives; Abstract; 1. Alzheimer's Disease -- Historic Overview; 2. Current Status and Prevalence of AD; 3. Risk Factors for AD; 4. Cholinergic Theory; 5. Cholinesterases; 6. Current Therapeutic Approaches to AD; 7. Conclusions; Acknowledgements; Conflict of Interest; References; Chapter 2: Challenges in Designing Therapeutic Agents for Treatingalzheimer's Disease-From Serendipity to Rationality.
505 8 ▼a AbstractIntroduction; Alzheimer's Disease (AD); Challenges in Designing Alzheimer's Medicines; Symptomatic Drugs; Disease Modifying Drugs (Investigative Approaches); Rational Approaches to Design AD Drugs; Multi-Target-Directed Ligand (MTDL) Design Strategy; Concluding Remarks & Future Prospects; Acknowledgements; Conflict of Interest; Abbreviations; References; Chapter 3: Enzyme Inhibitors Involved in the Treatment of Alzheimer's Disease; Abstract; Introduction; Pathophysiology of Alzheimer Disease; Overview on Key Enzymes Involved in Alzheimer's Disease.
505 8 ▼a Clinically Used Enzymes Inhibitors for Alzheimer's DiseaseCurrent Enzyme-Targeted Drug Development Foralzheimer's Disease; Conclusions; Acknowledgements; Conflict of Interest; Abbreviations; References; Chapter 4: Towards Small Molecules as Therapies for Alzheimer's Disease and Other Neurodegenerative Disorders; Abstract; Introduction to Neurodegenerative Diseases; Alzheimer's Disease: Etiology and the -Amyloid Hypothesis; BACE1 and the -Amyloid Hypothesis; The Evolution of BACE1 Inhibitors; BACE1 Inhibitors: Uncovering "Chemical Truffles" in Pre-Clinical Drug Discovery.
505 8 ▼a HD and Mitochondrial DysfunctionThe Synergy Between Aggregation and Autophagy; Transcriptional Regulation; Other Biological Pathway Deficits; Perspectives for HD; Conclusive Remarks; Acknowledgements; Conflict of Interest; Abbreviations; References; Chapter 5: Multifunctional Enzyme Inhibition for Neuroprotection -- A Focus on MAO, NOS, and AChE Inhibitors; Abstract; Introduction; Monoamine Oxidase -- Isoforms and Function; Nitric Oxide Synthase (NOS) -- Isoforms and Structure; Acetylcholinesterase -- Structure and Function; Conclusion and Future Developments; Acknowledgements.
520 ▼a Drug Design and Discovery in Alzheimer's Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an.
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Alzheimer's disease ▼x Chemotherapy.
650 0 ▼a Alzheimer's disease ▼x Treatment.
650 0 ▼a Drugs ▼x Design.
650 2 ▼a Alzheimer Disease ▼x drug therapy.
650 2 ▼a Drug Delivery Systems.
700 1 ▼a Rahman, Atta-ur-, ▼d 1942-.
700 1 ▼a Choudhary, Muhammad Iqbal.
856 4 0 ▼3 ScienceDirect ▼u https://oca.korea.ac.kr/link.n2s?url=http://www.sciencedirect.com/science/book/9780128039595
945 ▼a KLPA
991 ▼a E-Book(소장)

소장정보

No. 소장처 청구기호 등록번호 도서상태 반납예정일 예약 서비스
No. 1 소장처 중앙도서관/e-Book 컬렉션/ 청구기호 CR 616.832061 등록번호 E14004295 도서상태 대출불가(열람가능) 반납예정일 예약 서비스 M

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