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Ion channels and disease [electronic resource] : channelopathies

Ion channels and disease [electronic resource] : channelopathies

자료유형
E-Book(소장)
개인저자
Ashcroft, Frances M.
서명 / 저자사항
Ion channels and disease [electronic resource] : channelopathies / Frances M. Ashcroft.
발행사항
San Diego :   Academic Press,   2000.  
형태사항
1 online resource (xxi, 481 p.) : ill. (some col.).
기타형태 저록
Print version:   Ashcroft, Frances M.   Ion channels and disease.   San Diego : Academic Press, 2000   0120653109   9780120653102   (211009) 000000701482  
ISBN
9781435601123 (electronic bk.) 1435601122 (electronic bk.)
요약
Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype.
일반주기
Title from e-Book title page.  
내용주기
Preface. -- Introduction. -- From Gene to Protein. -- How Channels Work. -- Methods for Studying Ion Channels. -- Voltage-Gated Na<sup>+</sup> Channels. -- Voltage-Gated K<sup>+</sup> Channels. -- Ca-Activated K<sup>+</sup> Channels. -- Inward Rectifier K<sup>+</sup> Channels. -- Voltage-Gated Ca<sup>2+</sup> Channels. -- Voltage-Gated Cl<sup>-</sup> Channels. -- Cyclic Nucleotide-Gated Channels. -- CFTR. -- Epithelia Na<sup>+</sup> Channels. -- Ligand-Gated Ca<sup>2+</sup> Channels. -- ACh Receptor Channels. -- Glutamate Receptor Channels. -- Glycine Receptors. -- GABA Receptors. -- Water Channels. -- Gap Junction Channels. -- Antibodies to Ion Channels. -- Ion Channels in Viruses. -- Ion Channels as Lethal Agents. -- A Miscellany of Ion Channels. -- The Last Word. -- References. -- Subject Index.
서지주기
Includes bibliographical references (p. 419-464) and index.
이용가능한 다른형태자료
Issued also as a book.  
일반주제명
Ion channels. Pathology, Molecular. Ion Channels --physiology. Genetic Diseases, Inborn --physiopathology. Membrane Proteins --physiology. Metabolism, Inborn Errors --physiopathology.
바로가기
ScienceDirect   URL
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020 ▼a 9781435601123 (electronic bk.)
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082 0 4 ▼a 616.07 ▼2 23
084 ▼a 616.07 ▼2 DDCK
090 ▼a 616.07
100 1 ▼a Ashcroft, Frances M.
245 1 0 ▼a Ion channels and disease ▼h [electronic resource] : ▼b channelopathies / ▼c Frances M. Ashcroft.
260 ▼a San Diego : ▼b Academic Press, ▼c 2000.
300 ▼a 1 online resource (xxi, 481 p.) : ▼b ill. (some col.).
500 ▼a Title from e-Book title page.
504 ▼a Includes bibliographical references (p. 419-464) and index.
505 0 ▼a Preface. -- Introduction. -- From Gene to Protein. -- How Channels Work. -- Methods for Studying Ion Channels. -- Voltage-Gated Na<sup>+</sup> Channels. -- Voltage-Gated K<sup>+</sup> Channels. -- Ca-Activated K<sup>+</sup> Channels. -- Inward Rectifier K<sup>+</sup> Channels. -- Voltage-Gated Ca<sup>2+</sup> Channels. -- Voltage-Gated Cl<sup>-</sup> Channels. -- Cyclic Nucleotide-Gated Channels. -- CFTR. -- Epithelia Na<sup>+</sup> Channels. -- Ligand-Gated Ca<sup>2+</sup> Channels. -- ACh Receptor Channels. -- Glutamate Receptor Channels. -- Glycine Receptors. -- GABA Receptors. -- Water Channels. -- Gap Junction Channels. -- Antibodies to Ion Channels. -- Ion Channels in Viruses. -- Ion Channels as Lethal Agents. -- A Miscellany of Ion Channels. -- The Last Word. -- References. -- Subject Index.
520 ▼a Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype.
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Ion channels.
650 0 ▼a Pathology, Molecular.
650 2 ▼a Ion Channels ▼x physiology.
650 2 ▼a Genetic Diseases, Inborn ▼x physiopathology.
650 2 ▼a Membrane Proteins ▼x physiology.
650 2 ▼a Metabolism, Inborn Errors ▼x physiopathology.
776 0 8 ▼i Print version: ▼a Ashcroft, Frances M. ▼t Ion channels and disease. ▼d San Diego : Academic Press, 2000 ▼z 0120653109 ▼z 9780120653102 ▼w (211009) 000000701482
856 4 0 ▼3 ScienceDirect ▼u https://oca.korea.ac.kr/link.n2s?url=http://www.sciencedirect.com/science/book/9780120653102
945 ▼a KLPA
991 ▼a E-Book(소장)

소장정보

No. 소장처 청구기호 등록번호 도서상태 반납예정일 예약 서비스
No. 1 소장처 중앙도서관/e-Book 컬렉션/ 청구기호 CR 616.07 등록번호 E14004133 도서상태 대출불가(열람가능) 반납예정일 예약 서비스 M

컨텐츠정보

목차

Preface	
Introduction	
From Gene to Protein	
How Channels Work	
Methods for Studying Ion Channels	
Voltage-Gated Na + Channels	
Voltage-Gated K + Channels	
Ca-Activated K + Channels	
Inward Rectifier K + Channels	
Voltage-Gated Ca 2+ Channels	
Voltage-Gated Cl - Channels	
Cyclic Nucleotide-Gated Channels CFTR	
Epithelia Na + Channels	
Ligand-Gated Ca 2+ Channels	
ACh Receptor Channels	
Glutamate Receptor Channels	
Glycine Receptors	
GABA Receptors	
Water Channels	
Gap Junction Channels	
Antibodies to Ion Channels	
Ion Channels in Viruses	
Ion Channels as Lethal Agents	
A Miscellany of Ion Channels	
The Last Word	
References	
Subject Index

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