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Universes in delicate balance [electronic resource] : chemokines and the nervous system / 1st ed

Universes in delicate balance [electronic resource] : chemokines and the nervous system / 1st ed

자료유형
E-Book(소장)
개인저자
Ransohoff, Richard M.
서명 / 저자사항
Universes in delicate balance [electronic resource] : chemokines and the nervous system / editors, R.M. Ransohoff ... [et al.].
판사항
1st ed.
발행사항
Amsterdam ;   New York :   Elsevier,   2002.  
형태사항
1 online resource (xvi, 387 p.) : ill. (some col.).
ISBN
1423755472 (electronic bk.) 9781423755470 (electronic bk.)
요약
It is commonly acknowledged that the nervous system and the immune system, those most complex of networks, share attributes beyond their intricacy. Elements common to the two systems include memory, connectivity, flexibility and developmental selection of cellular composition by a rigorous process involving widespread programmed cell death. There is one salient difference: the cells of the immune system are predominantly in constant motion, while post-mitotic neurons and glia are largely fixed in place. Therefore, chemokines, initially characterized as leukocyte chemoattractants, have for the last one and one-half decades been intensely and productively studied in the contexts of inflammation, immunity and hematopoietic development. Only recently have the two fields, neurobiology and immunology, displayed mutual interests in chemokines. This convergence of the two tribes of investigators was catalyzed by the finding that SDF-1 (now known as CXCL12) and its receptor, CXCR4, exerted significant and similar functions in development of both nervous and immune systems. Indeed CXCL12 and CXCR4 were required, in an uncannily similar fashion, for retention of pre-B lymphocytes at sites of maturation in the bone marrow and of neuronal progenitors in the external granule cell layer of the developing cerebellum. Recent reports indicate that chemoattraction of cerebellar granule cells through CXCR4 can be suppressed by reverse signaling initiated by binding of soluble eph receptors to transmembrane ephrin B, thereby establishing a link between chemokine action and a cardinal patterning system of the developing nervous system. As may be anticipated when a dam breaks, a massive influx of correlative observations in the nervous and immune systems is likely to ensue. This volume represents the state of current knowledge. To this end, introductory material for both systems is provided. Basic and advanced 'chemokinology' are presented. The recipe for making a nervous system (both ingredients and instructions for preparation) is described, as are the roles of chemokines and their receptors in making an immune system. Given their importance and complexity, CXCL12/CXCR4 interactions are separately treated in varying contexts. The field of 'neurobiology of chemokines' has not lain fallow during the last ten years. During much of this time the principal focus has been on neuroinflammation. Linking the immune and nervous systems are explanations of the functions of chemokines and their receptors for resident brain macrophages, the microglia, the unique cerebrovascular endothelium and angiogenesis. Understanding human disease is the goal of much of this research. New discoveries are being made and reported at a gratifying rate. It is expected that this volume will promote the steady production and application of useful new knowledge in this developing field. It provides a unique single-source database for basic neurobiology highlighting the fundamental aspects of chemokines and discussing the relations of chemokine science to animal models and human disease.
일반주기
Title from e-Book title page.  
내용주기
Front Cover; UNIVERSES IN DELICATE BALANCE: CHEMOKINES AND THE NERVOUS SYSTEM; Copyright Page; Dedication; Preface; List of Contributors; CONTENTS; Section 1: The Nervous System; Section 2: The Chemokine System; Section 3: Chemokines and Neural Inflammation in Model Systems; Section 4: Chemokines and Effects on other CNS Processes and Resident Cells; Section 5: Chemokines and Neurological Diseases; Subject Index.
서지주기
Includes bibliographical references and index.
이용가능한 다른형태자료
Issued also as a book.  
일반주제명
Neuroimmunology. Chemokines. Nervous System --immunology. Chemokines --physiology. Inflammation --immunology. Nervous System Diseases --immunology. Receptors, Chemokine --physiology.
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ScienceDirect   URL
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082 0 0 ▼a 616.8/0479 ▼2 23
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245 0 0 ▼a Universes in delicate balance ▼h [electronic resource] : ▼b chemokines and the nervous system / ▼c editors, R.M. Ransohoff ... [et al.].
250 ▼a 1st ed.
260 ▼a Amsterdam ; ▼a New York : ▼b Elsevier, ▼c 2002.
300 ▼a 1 online resource (xvi, 387 p.) : ▼b ill. (some col.).
500 ▼a Title from e-Book title page.
504 ▼a Includes bibliographical references and index.
505 0 ▼a Front Cover; UNIVERSES IN DELICATE BALANCE: CHEMOKINES AND THE NERVOUS SYSTEM; Copyright Page; Dedication; Preface; List of Contributors; CONTENTS; Section 1: The Nervous System; Section 2: The Chemokine System; Section 3: Chemokines and Neural Inflammation in Model Systems; Section 4: Chemokines and Effects on other CNS Processes and Resident Cells; Section 5: Chemokines and Neurological Diseases; Subject Index.
520 ▼a It is commonly acknowledged that the nervous system and the immune system, those most complex of networks, share attributes beyond their intricacy. Elements common to the two systems include memory, connectivity, flexibility and developmental selection of cellular composition by a rigorous process involving widespread programmed cell death. There is one salient difference: the cells of the immune system are predominantly in constant motion, while post-mitotic neurons and glia are largely fixed in place. Therefore, chemokines, initially characterized as leukocyte chemoattractants, have for the last one and one-half decades been intensely and productively studied in the contexts of inflammation, immunity and hematopoietic development. Only recently have the two fields, neurobiology and immunology, displayed mutual interests in chemokines. This convergence of the two tribes of investigators was catalyzed by the finding that SDF-1 (now known as CXCL12) and its receptor, CXCR4, exerted significant and similar functions in development of both nervous and immune systems. Indeed CXCL12 and CXCR4 were required, in an uncannily similar fashion, for retention of pre-B lymphocytes at sites of maturation in the bone marrow and of neuronal progenitors in the external granule cell layer of the developing cerebellum. Recent reports indicate that chemoattraction of cerebellar granule cells through CXCR4 can be suppressed by reverse signaling initiated by binding of soluble eph receptors to transmembrane ephrin B, thereby establishing a link between chemokine action and a cardinal patterning system of the developing nervous system. As may be anticipated when a dam breaks, a massive influx of correlative observations in the nervous and immune systems is likely to ensue. This volume represents the state of current knowledge. To this end, introductory material for both systems is provided. Basic and advanced 'chemokinology' are presented. The recipe for making a nervous system (both ingredients and instructions for preparation) is described, as are the roles of chemokines and their receptors in making an immune system. Given their importance and complexity, CXCL12/CXCR4 interactions are separately treated in varying contexts. The field of 'neurobiology of chemokines' has not lain fallow during the last ten years. During much of this time the principal focus has been on neuroinflammation. Linking the immune and nervous systems are explanations of the functions of chemokines and their receptors for resident brain macrophages, the microglia, the unique cerebrovascular endothelium and angiogenesis. Understanding human disease is the goal of much of this research. New discoveries are being made and reported at a gratifying rate. It is expected that this volume will promote the steady production and application of useful new knowledge in this developing field. It provides a unique single-source database for basic neurobiology highlighting the fundamental aspects of chemokines and discussing the relations of chemokine science to animal models and human disease.
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Neuroimmunology.
650 0 ▼a Chemokines.
650 1 2 ▼a Nervous System ▼x immunology.
650 2 2 ▼a Chemokines ▼x physiology.
650 2 2 ▼a Inflammation ▼x immunology.
650 2 2 ▼a Nervous System Diseases ▼x immunology.
650 2 2 ▼a Receptors, Chemokine ▼x physiology.
700 1 ▼a Ransohoff, Richard M.
856 4 0 ▼3 ScienceDirect ▼u https://oca.korea.ac.kr/link.n2s?url=http://www.sciencedirect.com/science/book/9780444510020
945 ▼a KLPA
991 ▼a E-Book(소장)

소장정보

No. 소장처 청구기호 등록번호 도서상태 반납예정일 예약 서비스
No. 1 소장처 중앙도서관/e-Book 컬렉션/ 청구기호 CR 616.80479 등록번호 E14003802 도서상태 대출불가(열람가능) 반납예정일 예약 서비스 M

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