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Handbook of microdialysis [electronic resource] : methods, applications and perspectives / 1st ed

Handbook of microdialysis [electronic resource] : methods, applications and perspectives / 1st ed

자료유형
E-Book(소장)
개인저자
Westerink, B. H. C. Cremers, Thomas Ivo Franciscus Hubert, 1972-.
서명 / 저자사항
Handbook of microdialysis [electronic resource] : methods, applications and perspectives / edited by Ben H.C. Westerink and Thomas I.F.H. Cremers.
판사항
1st ed.
발행사항
Amsterdam ;   Boston :   Elsevier Academic Press,   2007.  
형태사항
1 online resource (x, 697 p.) : ill.
총서사항
Handbook of behavioral neuroscience,1569-7339 ; v. 16
ISBN
9780444522764 044452276X 9780080469669 (electronic bk.) 0080469663 (electronic bk.)
요약
Microdialysis is currently one of the most important in vivo sampling methods in physiology and pharmacology. It is used to determine the chemical components of the fluid in the extracellular space of tissues. The technique is now well established in neuroscience research and is used excessively in behavioral neuroscience to determine the concentrations and identities of molecules in brain tissues, and their change due to behavior, hormonal and transmitter changes in the nervous system. The book provides a detailed comprehensive overview of the technology and its applications, including application in pathology, drug development, and the application in the clinic. The authors are all well known researchers in Neuroscience and experts in the use of Microdialysis. Organized into two parts of seven sections, the Handbook of Microdialysis critically examines recent developments in the field through a variety of chapters written by an internationally acclaimed group of authors. It is the first comprehensive handbook covering the technology of Microdialysis and its applications in Neuroscience. * Presents microdialysis methods and interpretation including the technical aspects of microdialysis as a sampling technique followed by the analytical chemical methods * Discusses the role of microdialysis in pharmacology, drug development and models of CNS pathology * Includes clinical applications of microdialysis.
일반주기
Title from e-Book title page.  
내용주기
PART ONE -- Interpretation and significance. -- What Did We Learn from Microdialysis? -- Microdialysis: fact or artefact . -- Insights into Glutamate Physiology: Contribution of Studies Utilizing In Vivo Microdialysis. -- The Validity of Intracerebral Microdialysis. -- Microdialysis in the Brain of Anaesthetized vs Freely Moving Animals. -- Quantitative Aspects of Brain Microdialysis: Insights from Voltammetric Measurements of Dopamine next to Microdialysis Probes. -- -- Methods. -- New methodological aspects of microdialysis. -- Principles of Quantitative Microdialysis. -- Automation of Blood and Microdialysis Sampling: Combinatorial Pharmacology. -- Dopamine-Acetylcholine Interactions in the Brain Studied by In Vivo Microdialysis. -- Microdialysis as a Platform for Multidisciplinary Strategies. -- Ultraslow Microfiltration and Microdialysis for in vivo Sampling: Principle, Techniques and Applications. -- Analytical chemical aspects of microdialysis -- Liquid Chromatographic Methods Used for Microdialysis. -- Microdialysis Coupled with Liquid Chromatography / Mass Spectrometry. -- Sampling Improvement of the Temporal Resolution of Brain Microdialysis: Sampling in Seconds. -- In Vivo Peptidomics: Discovery and Monitoring of Neuropeptides Using Microdialysis and Liquid Chromatography with Mass Spectrometry. -- PART TWO -- Microdialysis and the study of behaviour. -- Microdialysis to Study the Effects of Stress on Serotonin, Corticosterone and Behaviour. -- Microdialysis of Dopamine and Norepinephrine During Conditioning and Operant Behaviour. -- Microdialysis in the Study of Behavior Reinforcement and Inhibition. -- Changes in Acetylcholine Extracellular Levels During Cognitive Processes. -- CNS Pathology models. -- Microdialysis in Genetically Altered Animals. -- The Use of Microdialysis in Neuropsychiatric Disease Models. -- The Use of Microdialysis for the Study of Neurological Disorders. -- Online Glucose and Lactate Monitoring During Physiological and Pathological Conditions. -- Microdialysis in Pain Research. -- Role of microdialysis in drug development. -- The Role of Microdialysis in Drug Discovery: Focus on Antipsychotic Agents. -- Use of Microdialysis in Drug Discovery and Development: Industry and Regulatory Perspectives. -- The Use of Brain Microdialysis in Antidepressant Drug Research. -- Microdialysis as a Method to Study Blood-Brain Barrier Transport Mechanisms. -- Assaying Protein Unbound Drugs Using Microdialysis Techniques. -- Microdialysis for Characterization of PK/PD Relationships. -- Application of Microdialysis in Pharmacokinetic Studies -- Clinical applications. -- Microdialysis in Clinical Drug Delivery Studies. -- Transport of Glucose to a Probe in Adipose Tissue. -- Microdialysis in the Human Brain: Clinical applications.
서지주기
Includes bibliographical references and index.
이용가능한 다른형태자료
Issued also as a book.  
일반주제명
Brain microdialysis. Microdialysis --methods.
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ScienceDirect   URL
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245 0 0 ▼a Handbook of microdialysis ▼h [electronic resource] : ▼b methods, applications and perspectives / ▼c edited by Ben H.C. Westerink and Thomas I.F.H. Cremers.
250 ▼a 1st ed.
260 ▼a Amsterdam ; ▼a Boston : ▼b Elsevier Academic Press, ▼c 2007.
300 ▼a 1 online resource (x, 697 p.) : ▼b ill.
490 1 ▼a Handbook of behavioral neuroscience, ▼x 1569-7339 ; ▼v v. 16
500 ▼a Title from e-Book title page.
504 ▼a Includes bibliographical references and index.
505 0 ▼a PART ONE -- Interpretation and significance. -- What Did We Learn from Microdialysis? -- Microdialysis: fact or artefact . -- Insights into Glutamate Physiology: Contribution of Studies Utilizing In Vivo Microdialysis. -- The Validity of Intracerebral Microdialysis. -- Microdialysis in the Brain of Anaesthetized vs Freely Moving Animals. -- Quantitative Aspects of Brain Microdialysis: Insights from Voltammetric Measurements of Dopamine next to Microdialysis Probes. -- -- Methods. -- New methodological aspects of microdialysis. -- Principles of Quantitative Microdialysis. -- Automation of Blood and Microdialysis Sampling: Combinatorial Pharmacology. -- Dopamine-Acetylcholine Interactions in the Brain Studied by In Vivo Microdialysis. -- Microdialysis as a Platform for Multidisciplinary Strategies. -- Ultraslow Microfiltration and Microdialysis for in vivo Sampling: Principle, Techniques and Applications. -- Analytical chemical aspects of microdialysis -- Liquid Chromatographic Methods Used for Microdialysis. -- Microdialysis Coupled with Liquid Chromatography / Mass Spectrometry. -- Sampling Improvement of the Temporal Resolution of Brain Microdialysis: Sampling in Seconds. -- In Vivo Peptidomics: Discovery and Monitoring of Neuropeptides Using Microdialysis and Liquid Chromatography with Mass Spectrometry. -- PART TWO -- Microdialysis and the study of behaviour. -- Microdialysis to Study the Effects of Stress on Serotonin, Corticosterone and Behaviour. -- Microdialysis of Dopamine and Norepinephrine During Conditioning and Operant Behaviour. -- Microdialysis in the Study of Behavior Reinforcement and Inhibition. -- Changes in Acetylcholine Extracellular Levels During Cognitive Processes. -- CNS Pathology models. -- Microdialysis in Genetically Altered Animals. -- The Use of Microdialysis in Neuropsychiatric Disease Models. -- The Use of Microdialysis for the Study of Neurological Disorders. -- Online Glucose and Lactate Monitoring During Physiological and Pathological Conditions. -- Microdialysis in Pain Research. -- Role of microdialysis in drug development. -- The Role of Microdialysis in Drug Discovery: Focus on Antipsychotic Agents. -- Use of Microdialysis in Drug Discovery and Development: Industry and Regulatory Perspectives. -- The Use of Brain Microdialysis in Antidepressant Drug Research. -- Microdialysis as a Method to Study Blood-Brain Barrier Transport Mechanisms. -- Assaying Protein Unbound Drugs Using Microdialysis Techniques. -- Microdialysis for Characterization of PK/PD Relationships. -- Application of Microdialysis in Pharmacokinetic Studies -- Clinical applications. -- Microdialysis in Clinical Drug Delivery Studies. -- Transport of Glucose to a Probe in Adipose Tissue. -- Microdialysis in the Human Brain: Clinical applications.
520 ▼a Microdialysis is currently one of the most important in vivo sampling methods in physiology and pharmacology. It is used to determine the chemical components of the fluid in the extracellular space of tissues. The technique is now well established in neuroscience research and is used excessively in behavioral neuroscience to determine the concentrations and identities of molecules in brain tissues, and their change due to behavior, hormonal and transmitter changes in the nervous system. The book provides a detailed comprehensive overview of the technology and its applications, including application in pathology, drug development, and the application in the clinic. The authors are all well known researchers in Neuroscience and experts in the use of Microdialysis. Organized into two parts of seven sections, the Handbook of Microdialysis critically examines recent developments in the field through a variety of chapters written by an internationally acclaimed group of authors. It is the first comprehensive handbook covering the technology of Microdialysis and its applications in Neuroscience. * Presents microdialysis methods and interpretation including the technical aspects of microdialysis as a sampling technique followed by the analytical chemical methods * Discusses the role of microdialysis in pharmacology, drug development and models of CNS pathology * Includes clinical applications of microdialysis.
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Brain microdialysis.
650 2 ▼a Microdialysis ▼x methods.
700 1 ▼a Westerink, B. H. C.
700 1 ▼a Cremers, Thomas Ivo Franciscus Hubert, ▼d 1972-.
830 0 ▼a Handbook of behavioral neuroscience ; ▼v v. 16.
856 4 0 ▼3 ScienceDirect ▼u https://oca.korea.ac.kr/link.n2s?url=http://www.sciencedirect.com/science/book/9780444522764
945 ▼a KLPA
991 ▼a E-Book(소장)

소장정보

No. 소장처 청구기호 등록번호 도서상태 반납예정일 예약 서비스
No. 1 소장처 중앙도서관/e-Book 컬렉션/ 청구기호 CR 616.804754 등록번호 E14003392 도서상태 대출불가(열람가능) 반납예정일 예약 서비스 M

컨텐츠정보

목차

Cover; Handbook of Microdialysis: Methods, Applications and Perspectives; Copyright page; Contents; List of Contributors; Preface; Part One; Section 1: Interpretation and Significance; Chapter 1.1. What did we learn from microdialysis?; I. Introduction; II. Early studies of chemical transmission in the brain in vivo; III. The introduction of microdialysis; IV. Early microdialysis studies in Stockholm; V. Microdialysis and neuropharmacology; VI. Microdialysis problems; VII. Conclusions; References; Chapter 1.2. Microdialysis of glutamate and GABA in the brain: analysis and interpretation
I. IntroductionII. Analysis of GABA and glutamate; III. Microdialysis of glutamate: interpretation; IV. Microdialysis of GABA: interpretation; V. Conclusions; References; Chapter 1.3. Insights into glutamate physiology: contribution of studies utilizing in vivo microdialysis; I. Glutamate sampling techniques; II. Astrocytes maintain neuronal glutamate; III. Glutamate receptors; IV. Cellular processes capable of glutamate release; V. Synaptic origin of stimulated release; VI. Therapeutic targets detected by microdialysis; VII. Conclusion; References
Chapter 1.4. The validity of intracerebral microdialysisI. Introduction; II. Theory of single-probe microdialysis; III. Studying basal DA to infer errors in quantitative microdialysis; IV. Data from other neurotransmitters; V. Conclusions; References; Chapter 1.5. Microdialysis in the brain of anesthetized vs. freely moving animals; I. Introduction; II. Advantages and drawbacks of microdialysis in anesthetized and freely moving animals; III. The use of anesthesia in microdialysis; IV. The effects of anesthetics on neurotransmitter systems in the brain
V. Comparison of neurotransmitter dynamics in the freely moving and anesthetized preparationVI. Conclusions; Acknowledgments; References; Chapter 1.6. Quantitative aspects of brain microdialysis: insights from voltammetric measurements of dopamine next to microdialysis probes; I. Introduction; II. The issue of in vivo calibration; III. An example of in vitro microdialysis where E and R are different; IV. A comment about the concentration-independence of E and R; V. Voltammetry as a tool to investigate in vivo recovery of dopamine
VI. Comparison of the in vivo extraction and recovery of dopamineVII. A comment regarding in vivo dopamine recovery at zero perfusion velocity; VIII. How important is the difference between E and R?; IX. What do microdialysis results tell us?; X. Concluding remarks; Acknowledgments; References; Section 2: Methods; Chapter 2.1. New methodological aspects of microdialysis; I. Introduction; II. Advancements in microdialysis sampling; III. Conclusions; References; Chapter 2.2. Principles of quantitative microdialysis; I. Introduction; II. Mathematical framework; III. Experimental methodology
IV. Analysis

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