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Bone cancer [electronic resource] : progression and therapeutic approaches / 1st ed

Bone cancer [electronic resource] : progression and therapeutic approaches / 1st ed

자료유형
E-Book(소장)
개인저자
Heymann, Dominique.
서명 / 저자사항
Bone cancer [electronic resource] : progression and therapeutic approaches / edited by Dominique Heymann.
판사항
1st ed.
발행사항
Amsterdam ;   Boston ;   London :   Academic,   2010.  
형태사항
1 online resource (xv, 472 p., [10] p. of plates) : ill.
ISBN
9780123748959 (electronic bk.) 012374895X (electronic bk.)
요약
The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches. Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Feature Presents a comprehensive, translational source for all aspects of bone cancer in one reference work Bone cancer experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches. Clear presentation by bone biologists of the cellular and molecular mechanisms underlying bone tumors and bone cancer metastasis as well as the genomic and proteomic assays used in detecting cancer within given organ systems Clear presentation by oncologists and radiologists of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches Benefit Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone cancer issues, as opposed to searching through thousands of journal articles. Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Correct diagnosis (and therefore correct treatment) of cancer depends on a strong understanding of the molecular basis for the disease - both oncologists and radiologists will benefit Bone biologists will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays.
일반주기
Title from e-Book title page.  
내용주기
Section 1: Introduction -- Genetic control, frequencies and epidemiology of bone cancers -- The incidence and progression of metastatic bone lesions -- Section 2: Bone microenvironment and bone cancer -- Bone microenvironment and tumor growth -- Osteoblast Differentiation and Cell Signalling -- Osteoclast Differentiation and Function -- Cytokines in bone remodeling and bone tumors -- Proteases and bone tumors -- therapeutic approaches -- Section 3: Bone markers -- Early bone metastasis -- Bone remodeling markers and bone cancer -- Proteomic of bone cancers -- Genomic Alterations in Bone Tumors -- Biology of bone tumors and new diagnostic tools -- Gene profiling of osteosarcoma -- Molecular pathology of osteosarcoma -- Histopathology of prostate and breast metastases -- Technical aspects: how do we best prepare bone samples for proper histological analysis? -- Section 4: Myeloma, odontogenic tumors and bone metastases -- Multiple myeloma bone diseases -- Osteolytic lesions -- Bone metastases of prostatic cancer -- Bone metastases of breast cancer -- Section 5: Primary bone tumors -- Osteosarcoma and osteoblasts: diagnosis and therapy -- Ewing sarcoma family of tumors: diagnosis and therapy -- Non-surgical treatment of chondrosarcoma: diagnosis and therapy -- Chondrosarcoma of bone: diagnosis and therapy -- Osteoclast-rich lesions of bone: diagnosis and therapy -- Section 6: Imaging of bone cancers -- Interventional Radiologic Techniques -- Imaging of bone metastases -- Diagnosis of bone metastases -- Section 7: Pain control in bone cancers -- Pain control with radiotherapy -- Mechanisms and management of bone cancer pain -- Malignant skeletal pain -- Section 8: New therapeutic advances of bone cancers -- Primary bone tumors and novel therapeutic approaches -- Cytokine gene therapy in bone remodeling -- Bisphosphonates -- Multi-targeted approach -- RANKL and targeted therapy -- Apoptosis and drug resistance.
서지주기
Includes bibliographical references and index.
이용가능한 다른형태자료
Issued also as a book.  
일반주제명
Bones --Cancer. Bones --Cancer --Treatment. Bone Neoplasms. Bone Neoplasms --therapy.
바로가기
ScienceDirect   URL
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245 0 0 ▼a Bone cancer ▼h [electronic resource] : ▼b progression and therapeutic approaches / ▼c edited by Dominique Heymann.
250 ▼a 1st ed.
260 ▼a Amsterdam ; ▼a Boston ; ▼a London : ▼b Academic, ▼c 2010.
300 ▼a 1 online resource (xv, 472 p., [10] p. of plates) : ▼b ill.
500 ▼a Title from e-Book title page.
504 ▼a Includes bibliographical references and index.
505 0 ▼a Section 1: Introduction -- Genetic control, frequencies and epidemiology of bone cancers -- The incidence and progression of metastatic bone lesions -- Section 2: Bone microenvironment and bone cancer -- Bone microenvironment and tumor growth -- Osteoblast Differentiation and Cell Signalling -- Osteoclast Differentiation and Function -- Cytokines in bone remodeling and bone tumors -- Proteases and bone tumors -- therapeutic approaches -- Section 3: Bone markers -- Early bone metastasis -- Bone remodeling markers and bone cancer -- Proteomic of bone cancers -- Genomic Alterations in Bone Tumors -- Biology of bone tumors and new diagnostic tools -- Gene profiling of osteosarcoma -- Molecular pathology of osteosarcoma -- Histopathology of prostate and breast metastases -- Technical aspects: how do we best prepare bone samples for proper histological analysis? -- Section 4: Myeloma, odontogenic tumors and bone metastases -- Multiple myeloma bone diseases -- Osteolytic lesions -- Bone metastases of prostatic cancer -- Bone metastases of breast cancer -- Section 5: Primary bone tumors -- Osteosarcoma and osteoblasts: diagnosis and therapy -- Ewing sarcoma family of tumors: diagnosis and therapy -- Non-surgical treatment of chondrosarcoma: diagnosis and therapy -- Chondrosarcoma of bone: diagnosis and therapy -- Osteoclast-rich lesions of bone: diagnosis and therapy -- Section 6: Imaging of bone cancers -- Interventional Radiologic Techniques -- Imaging of bone metastases -- Diagnosis of bone metastases -- Section 7: Pain control in bone cancers -- Pain control with radiotherapy -- Mechanisms and management of bone cancer pain -- Malignant skeletal pain -- Section 8: New therapeutic advances of bone cancers -- Primary bone tumors and novel therapeutic approaches -- Cytokine gene therapy in bone remodeling -- Bisphosphonates -- Multi-targeted approach -- RANKL and targeted therapy -- Apoptosis and drug resistance.
520 ▼a The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches. Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Feature Presents a comprehensive, translational source for all aspects of bone cancer in one reference work Bone cancer experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches. Clear presentation by bone biologists of the cellular and molecular mechanisms underlying bone tumors and bone cancer metastasis as well as the genomic and proteomic assays used in detecting cancer within given organ systems Clear presentation by oncologists and radiologists of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches Benefit Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone cancer issues, as opposed to searching through thousands of journal articles. Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Correct diagnosis (and therefore correct treatment) of cancer depends on a strong understanding of the molecular basis for the disease - both oncologists and radiologists will benefit Bone biologists will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays.
530 ▼a Issued also as a book.
538 ▼a Mode of access: World Wide Web.
650 0 ▼a Bones ▼x Cancer.
650 0 ▼a Bones ▼x Cancer ▼x Treatment.
650 2 ▼a Bone Neoplasms.
650 2 ▼a Bone Neoplasms ▼x therapy.
700 1 ▼a Heymann, Dominique.
856 4 0 ▼3 ScienceDirect ▼u https://oca.korea.ac.kr/link.n2s?url=http://www.sciencedirect.com/science/book/9780123748959
945 ▼a KLPA
991 ▼a E-Book(소장)

소장정보

No. 소장처 청구기호 등록번호 도서상태 반납예정일 예약 서비스
No. 1 소장처 중앙도서관/e-Book 컬렉션/ 청구기호 CR 616.99471 등록번호 E14003002 도서상태 대출불가(열람가능) 반납예정일 예약 서비스 M

컨텐츠정보

목차

Section 1: Introduction
Genetic control, frequencies and epidemiology of bone cancers
The incidence and progression of metastatic bone lesions
Section 2: Bone microenvironment and bone cancer
Bone microenvironment and tumor growth
Osteoblast Differentiation and Cell Signalling
Osteoclast Differentiation and Function
Cytokines in bone remodeling and bone tumors
Proteases and bone tumors
therapeutic approaches
Section 3: Bone markers
Early bone metastasis
Bone remodeling markers and bone cancer
Proteomic of bone cancers
Genomic Alterations in Bone Tumors
Biology of bone tumors and new diagnostic tools
Gene profiling of osteosarcoma
Molecular pathology of osteosarcoma
Histopathology of prostate and breast metastases
Technical aspects: how do we best prepare bone samples for proper histological analysis?
Section 4: Myeloma, odontogenic tumors and bone metastases
Multiple myeloma bone diseases
Osteolytic lesions
Bone metastases of prostatic cancer
Bone metastases of breast cancer
Section 5: Primary bone tumors
Osteosarcoma and osteoblasts: diagnosis and therapy
Ewing sarcoma family of tumors: diagnosis and therapy
Non-surgical treatment of chondrosarcoma: diagnosis and therapy
Chondrosarcoma of bone: diagnosis and therapy
Osteoclast-rich lesions of bone: diagnosis and therapy
Section 6: Imaging of bone cancers
Interventional Radiologic Techniques
Imaging of bone metastases
Diagnosis of bone metastases
Section 7: Pain control in bone cancers
Pain control with radiotherapy
Mechanisms and management of bone cancer pain
Malignant skeletal pain
Section 8: New therapeutic advances of bone cancers
Primary bone tumors and novel therapeutic approaches
Cytokine gene therapy in bone remodeling
Bisphosphonates
Multi-targeted approach
RANKL and targeted therapy
Apoptosis and drug resistance.

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