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Biomarkers for Alzheimer's disease drug development

Biomarkers for Alzheimer's disease drug development

자료유형
단행본
개인저자
Perneczky, Robert.
서명 / 저자사항
Biomarkers for Alzheimer's disease drug development / edited by Robert Perneczky.
발행사항
New York :   Humana Press :   Springer,   c2018.  
형태사항
xv, 372 p. : ill. (some col.) ; 27 cm.
총서사항
Springer Protocols
ISBN
9781493977031 (hardcover) 1493977032 (hardcover)
요약
This volume aims to build a new generation of experts with a broader understanding of key topics in the Alzheimers disease field. Chapters guide readers through innovative approaches to the discovery of novel biomarkers in cerebrospinal fluid, innovation in blood-based biomarkers, a comprehensive overview of magnetic resonance imaging and molecular imaging approaches and their value for developing drugs for Alzheimers disease, cutting-edge developments in neuropathology and their relevance for Alzheimers disease trials, novel genomic strategies for biomarker development, and related topics including neuropsychological testing and advanced analytical methods.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Biomarkers for Alzheimer's Disease Drug Development aims to ensure successful results in the further study of this vital field.
내용주기
Epidemiology of Dementia: The Burden on Society, the Challenges for Research -- Population-based Approaches to Alzheimers Disease Prevention -- Systems Biology Methods for Alzheimers Disease Research towards Molecular Signatures, Subtypes and Stages and Precision Medicine. Application in Cohort Studies and Trials -- CSF Lipidomics Analysis: High-Resolution Mass Spectrometry Analytical Platform -- CSF N-glycomics using MALDI MS Techniques in Alzheimers Disease -- MicroRNA Profiling of Alzheimers Disease Cerebrospinal Fluid -- Validation of a Chemiluminescence Immunoassay for Measuring Amyloid- in Human Blood Plasma -- Mass Spectrometry-based Metabolomic Multiplatform for Alzheimers Disease Research -- Blood-based Biomarker Screening with Agnostic Biological Definitions for an Accurate Diagnosis within the Dimensional Spectrum of Neurodegenerative Diseases -- Functional Magnetic Resonance Imaging in Alzheimer Disease Drug Development -- Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies -- Hybrid PET-MRI in Alzheimers Disease Research -- Amyloid PET Imaging: Standardization and Integration with Other Alzheimer Disease Biomarkers -- The use of 18F-FDG PET in the Diagnostic Workup of Alzheimers Dementia -- Quantification of Tau Load in Alzheimers Disease Clinical Trials Using Positron Emission Tomography -- Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach -- Unbiased Lipidomics and Metabolomics of Human Brain Samples -- Neuropathological Assessment as an Endpoint in Clinical Trial Design -- Analysis of micro-RNA Expression by qPCR on a Microfluidics Platform for Alzheimers Disease Biomarker Discovery -- Telomere length shortening in Alzheimers disease procedures for a causal investigation using single nucleotide polymorphisms in a Mendelian Randomization study -- Quantifying miRNA Deregulation in Alzheimers Disease -- Imaging of Microglial Activation in Alzheimers Disease by [11C]PBR28 PET -- In Vivo Two-photon Calcium Imaging of Hippocampal Neurons in Alzheimer Mouse Models -- Cognitive Assessment in Alzheimers Disease Clinical Trials -- Data Mining and Machine Learning Methods for Dementia Research.
서지주기
Includes bibliographical references and index.
일반주제명
Alzheimer's disease. Biochemical markers. Alzheimer Disease. Biomarkers, Pharmacological.
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001 000045941424
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008 180514s2018 nyua b 001 0 eng d
020 ▼a 9781493977031 (hardcover)
020 ▼a 1493977032 (hardcover)
035 ▼a (OCoLC)1013181743
040 ▼a YDX ▼b eng ▼e rda ▼c YDX ▼d OCLCO ▼d KUB ▼d 211009
049 ▼a KUBA
050 4 ▼a RC523 ▼b .B56 2018
082 0 4 ▼a 616.8/311 ▼2 23
084 ▼a 616.8311 ▼2 DDCK
090 ▼a 616.8311 ▼b B615
245 0 0 ▼a Biomarkers for Alzheimer's disease drug development / ▼c edited by Robert Perneczky.
260 ▼a New York : ▼b Humana Press : ▼b Springer, ▼c c2018.
300 ▼a xv, 372 p. : ▼b ill. (some col.) ; ▼c 27 cm.
490 1 ▼a Springer Protocols
490 1 ▼a Methods in molecular biology, ▼x 1940-6029 ; ▼v volume 1750
504 ▼a Includes bibliographical references and index.
505 0 ▼a Epidemiology of Dementia: The Burden on Society, the Challenges for Research -- Population-based Approaches to Alzheimers Disease Prevention -- Systems Biology Methods for Alzheimers Disease Research towards Molecular Signatures, Subtypes and Stages and Precision Medicine. Application in Cohort Studies and Trials -- CSF Lipidomics Analysis: High-Resolution Mass Spectrometry Analytical Platform -- CSF N-glycomics using MALDI MS Techniques in Alzheimers Disease -- MicroRNA Profiling of Alzheimers Disease Cerebrospinal Fluid -- Validation of a Chemiluminescence Immunoassay for Measuring Amyloid- in Human Blood Plasma -- Mass Spectrometry-based Metabolomic Multiplatform for Alzheimers Disease Research -- Blood-based Biomarker Screening with Agnostic Biological Definitions for an Accurate Diagnosis within the Dimensional Spectrum of Neurodegenerative Diseases -- Functional Magnetic Resonance Imaging in Alzheimer Disease Drug Development -- Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies -- Hybrid PET-MRI in Alzheimers Disease Research -- Amyloid PET Imaging: Standardization and Integration with Other Alzheimer Disease Biomarkers -- The use of 18F-FDG PET in the Diagnostic Workup of Alzheimers Dementia -- Quantification of Tau Load in Alzheimers Disease Clinical Trials Using Positron Emission Tomography -- Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach -- Unbiased Lipidomics and Metabolomics of Human Brain Samples -- Neuropathological Assessment as an Endpoint in Clinical Trial Design -- Analysis of micro-RNA Expression by qPCR on a Microfluidics Platform for Alzheimers Disease Biomarker Discovery -- Telomere length shortening in Alzheimers disease procedures for a causal investigation using single nucleotide polymorphisms in a Mendelian Randomization study -- Quantifying miRNA Deregulation in Alzheimers Disease -- Imaging of Microglial Activation in Alzheimers Disease by [11C]PBR28 PET -- In Vivo Two-photon Calcium Imaging of Hippocampal Neurons in Alzheimer Mouse Models -- Cognitive Assessment in Alzheimers Disease Clinical Trials -- Data Mining and Machine Learning Methods for Dementia Research.
520 ▼a This volume aims to build a new generation of experts with a broader understanding of key topics in the Alzheimers disease field. Chapters guide readers through innovative approaches to the discovery of novel biomarkers in cerebrospinal fluid, innovation in blood-based biomarkers, a comprehensive overview of magnetic resonance imaging and molecular imaging approaches and their value for developing drugs for Alzheimers disease, cutting-edge developments in neuropathology and their relevance for Alzheimers disease trials, novel genomic strategies for biomarker development, and related topics including neuropsychological testing and advanced analytical methods.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Biomarkers for Alzheimer's Disease Drug Development aims to ensure successful results in the further study of this vital field.
650 0 ▼a Alzheimer's disease.
650 0 ▼a Biochemical markers.
650 2 ▼a Alzheimer Disease.
650 2 ▼a Biomarkers, Pharmacological.
655 2 ▼a Laboratory Manuals.
700 1 ▼a Perneczky, Robert.
830 0 ▼a Springer protocols (Series).
830 0 ▼a Methods in molecular biology (Clifton, N.J.) ; ▼v v. 1750.
945 ▼a KLPA

소장정보

No. 소장처 청구기호 등록번호 도서상태 반납예정일 예약 서비스
No. 1 소장처 과학도서관/Sci-Info(2층서고)/ 청구기호 616.8311 B615 등록번호 121244504 도서상태 대출가능 반납예정일 예약 서비스 B M

컨텐츠정보

목차

Epidemiology of Dementia: The Burden on Society, the Challenges for Research
Population-based Approaches to Alzheimer’s Disease Prevention
Systems Biology Methods for Alzheimer’s Disease Research towards Molecular Signatures, Subtypes and Stages and Precision Medicine. Application in Cohort Studies and Trials
CSF Lipidomics Analysis: High-Resolution Mass Spectrometry Analytical Platform
CSF N-glycomics using MALDI MS Techniques in Alzheimer’s Disease
MicroRNA Profiling of Alzheimer’s Disease Cerebrospinal Fluid
Validation of a Chemiluminescence Immunoassay for Measuring  Amyloid-β in Human Blood Plasma
Mass Spectrometry-based Metabolomic Multiplatform for Alzheimer’s Disease Research
Blood-based Biomarker Screening with Agnostic Biological Definitions for an Accurate Diagnosis within the Dimensional Spectrum of Neurodegenerative Diseases
Functional Magnetic Resonance Imaging in Alzheimer’ Disease Drug Development
Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies
Hybrid PET-MRI in Alzheimer’s Disease Research
Amyloid PET Imaging: Standardization and Integration with Other Alzheimer Disease Biomarkers
The use of 18F-FDG PET in the Diagnostic Workup of Alzheimer’s Dementia
Quantification of Tau Load in Alzheimer’s Disease Clinical Trials Using Positron Emission Tomography
Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach
Unbiased Lipidomics and Metabolomics of Human Brain Samples
Neuropathological Assessment as an Endpoint in Clinical Trial Design
Analysis of micro-RNA Expression by qPCR on a Microfluidics Platform for Alzheimer’s Disease Biomarker Discovery
Telomere length shortening in Alzheimer’s disease – procedures for a causal investigation using single nucleotide polymorphisms in a Mendelian Randomization study
Quantifying miRNA Deregulation in Alzheimer’s Disease
Imaging of Microglial Activation in Alzheimer’s Disease by [11C]PBR28 PET
In Vivo Two-photon Calcium Imaging of Hippocampal Neurons in Alzheimer Mouse Models
Cognitive Assessment in Alzheimer’s Disease Clinical Trials
Data Mining and Machine Learning Methods for Dementia Research.

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