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Intelligent surfaces in biotechnology : scientific and engineering concepts, enabling technologies, and translation to bio-oriented applications

Intelligent surfaces in biotechnology : scientific and engineering concepts, enabling technologies, and translation to bio-oriented applications (Loan 1 times)

Material type
단행본
Personal Author
Textor, Marcus. Grandin, H. Michelle.
Title Statement
Intelligent surfaces in biotechnology : scientific and engineering concepts, enabling technologies, and translation to bio-oriented applications / edited by Marcus Textor, H. Michelle Grandin.
Publication, Distribution, etc
Hoboken, N.J. :   John Wiley & Sons,   c2012.  
Physical Medium
xxv, 367 p., [32] p. of plates : ill. ; 25 cm.
ISBN
9780470536506
요약
"This resource gives a comprehensive overview of surface modifications for applications in biotechnology using intelligent coatings. The coverage includes chemical properties, characterization methods, coating techniques, state-of-the-art examples, and an outlook on the promising future of this technology. It enables the interested materials scientist, chemist, or engineer to gain a comprehensive overview of the field, highlighting applications, with each chapter written by an expert in that particular area. Applications covered include tissue engineering, biotribology, drug targeting and delivery, wound healing, biosensors, nanopatterning, and bioinspired design of new smart materials and surfaces"--
Content Notes
Machine generated contents note: Chapter 1. Stimulus Responsive Polymers as Intelligent Coatings for Biosensors: Architectures, Response Mechanisms, and Applications Vinalia Tjong, Jianming Zhang, Ashutosh Chilkoti and Stefan Zauscher 1.1 Introduction 1.2 SRP Architectures for Biosensor Applications 1.3 Mechanisms of Response 1.4 Sensing and Transduction Mechanisms 1.5 Limitations and Challenges 1.6 Conclusion and Outlook Chapter 2. Smart Surfaces for Point-of-Care Diagnostics Michael A. Nash, Allison L. Golden, John M. Hoffman, James L. Lai, and Patrick S. Stayton 2.1 Introduction 2.2 Standard Methods for Biomarker Purification, Enrichment, and Detection 2.3 Smart Reagents for Biomarker Purification and Processing 2.4 Sample-Processing Modules for Smart Conjugate Bioassays 2.5 Devices for use in Smart Conjugate Bioassays 2.6 Conclusions Chapter 3. Design of intelligent surface modifications and optimal liquid handling for nanoscale bioanalytical sensors Laurent Feuz, Fredrik Hook and Erik Reimhult 3.1 Introduction 3.2 Orthogonal small (nano) scale surface modification using molecular self-assembly 3.3 Alternative surface patterning strategies 3.4 The challenge of analytic transport 3.5 Concluding remarks Chapter 4. Intelligent Surfaces for Field Effect Transistor Based Nano-biosensing Akira Matsumoto, Yuji Miyahara Kazunori Kataoka 4.1 Introduction 4.2 Field effect transistor based biosensors 4.3 Intelligent surfaces for signal transduction and amplification of Bio-FETs 4.4 New targets of Bio-FETs 4.5 Future Perspective Chapter 5. Supported lipid bilayers: intelligent surfaces for ion channel recordings Andreas Janshoff and Claudia Steinem 5.1 Introduction 5.2 Supported lipid bilayers 5.3 Characterizatics of SSMs 5.4 Ion channels in SSMs 5.5 Future perspective: Ion channels in micropatterned membranes Chapter 6. Antimicrobial and anti-inflammatory intelligent surfaces Hans J. Griesser, Heike Hall. A. Toby , A. Jenkins, Stegani S. Griesser, Krasimir Vasilev 6.1 Introduction 6.2 Antibacterial strategies 6.3 Bioactive antibacterial surfaces 6.4 Stimulus-responsive antibacterial coatings for wound dressings 6.5 Anti-inflammatory surfaces 6.6 Conclusions and Outlook Chapter 7. Intelligent Polymer Thin Films and Coatings for Drug Delivery Alexander N. Zelikin, Brigitte Stadler 7.1 Introduction 7.2 Surface Mediated Drug Delivery 7.3 Drug Delivery Vehicles With Functional Polymer Coatings 7.4 Outlook Chapter 8. Micro- and Nanopatterning of Active Biomolecules and Cells Daniel Aydin, Vera C. Hirschfeld-Warmeken, Ilia Louban and Joachim P. Spatz 8.1 Introduction 8.2 Chemical Approaches for Protein Immobilization 8.3 Biomolecule patterning by "top-down" techniques 8.4 Biomolecule Nanoarrays bu Block Copolymer Nanolithography 8.5 Application of Nanostructured Surfaces to Study Cell Adhesion 8.6 Conclusion Chapter 9. Responsive polymer coatings for smart applications in chromatography, drug delivery systems and cell sheet engineering Rogerio P. Pirraco, Masayuki Yamato, Yoshikatsu, Kenichi Nagase, Masamichi Nakayama, Alexandra P. Marques, Rui L. Reis and Teruo Okano 9.1 Introduction 9.2 Temperature-responsive chromatography 9.3 Temperature-responsive polymer micelle 9.4 Temperature-responsive culture surfaces 9.5 Cell sheet Engineering 9.6 Conclusions .
Bibliography, Etc. Note
Includes bibliographical references and index.
Subject Added Entry-Topical Term
Biomedical materials. Biotechnology -- Materials. Smart materials. Surfaces (Technology)
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020 ▼a 9780470536506
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040 ▼a DLC ▼c DLC ▼d DLC ▼d 211009
050 0 0 ▼a R857.M3 ▼b I48 2012
082 0 0 ▼a 610.28/4 ▼2 22
084 ▼a 610.284 ▼2 DDCK
090 ▼a 610.284 ▼b I613
245 0 0 ▼a Intelligent surfaces in biotechnology : ▼b scientific and engineering concepts, enabling technologies, and translation to bio-oriented applications / ▼c edited by Marcus Textor, H. Michelle Grandin.
260 ▼a Hoboken, N.J. : ▼b John Wiley & Sons, ▼c c2012.
300 ▼a xxv, 367 p., [32] p. of plates : ▼b ill. ; ▼c 25 cm.
504 ▼a Includes bibliographical references and index.
505 8 ▼a Machine generated contents note: Chapter 1. Stimulus Responsive Polymers as Intelligent Coatings for Biosensors: Architectures, Response Mechanisms, and Applications Vinalia Tjong, Jianming Zhang, Ashutosh Chilkoti and Stefan Zauscher 1.1 Introduction 1.2 SRP Architectures for Biosensor Applications 1.3 Mechanisms of Response 1.4 Sensing and Transduction Mechanisms 1.5 Limitations and Challenges 1.6 Conclusion and Outlook Chapter 2. Smart Surfaces for Point-of-Care Diagnostics Michael A. Nash, Allison L. Golden, John M. Hoffman, James L. Lai, and Patrick S. Stayton 2.1 Introduction 2.2 Standard Methods for Biomarker Purification, Enrichment, and Detection 2.3 Smart Reagents for Biomarker Purification and Processing 2.4 Sample-Processing Modules for Smart Conjugate Bioassays 2.5 Devices for use in Smart Conjugate Bioassays 2.6 Conclusions Chapter 3. Design of intelligent surface modifications and optimal liquid handling for nanoscale bioanalytical sensors Laurent Feuz, Fredrik Hook and Erik Reimhult 3.1 Introduction 3.2 Orthogonal small (nano) scale surface modification using molecular self-assembly 3.3 Alternative surface patterning strategies 3.4 The challenge of analytic transport 3.5 Concluding remarks Chapter 4. Intelligent Surfaces for Field Effect Transistor Based Nano-biosensing Akira Matsumoto, Yuji Miyahara Kazunori Kataoka 4.1 Introduction 4.2 Field effect transistor based biosensors 4.3 Intelligent surfaces for signal transduction and amplification of Bio-FETs 4.4 New targets of Bio-FETs 4.5 Future Perspective Chapter 5. Supported lipid bilayers: intelligent surfaces for ion channel recordings Andreas Janshoff and Claudia Steinem 5.1 Introduction 5.2 Supported lipid bilayers 5.3 Characterizatics of SSMs 5.4 Ion channels in SSMs 5.5 Future perspective: Ion channels in micropatterned membranes Chapter 6. Antimicrobial and anti-inflammatory intelligent surfaces Hans J. Griesser, Heike Hall. A. Toby , A. Jenkins, Stegani S. Griesser, Krasimir Vasilev 6.1 Introduction 6.2 Antibacterial strategies 6.3 Bioactive antibacterial surfaces 6.4 Stimulus-responsive antibacterial coatings for wound dressings 6.5 Anti-inflammatory surfaces 6.6 Conclusions and Outlook Chapter 7. Intelligent Polymer Thin Films and Coatings for Drug Delivery Alexander N. Zelikin, Brigitte Stadler 7.1 Introduction 7.2 Surface Mediated Drug Delivery 7.3 Drug Delivery Vehicles With Functional Polymer Coatings 7.4 Outlook Chapter 8. Micro- and Nanopatterning of Active Biomolecules and Cells Daniel Aydin, Vera C. Hirschfeld-Warmeken, Ilia Louban and Joachim P. Spatz 8.1 Introduction 8.2 Chemical Approaches for Protein Immobilization 8.3 Biomolecule patterning by "top-down" techniques 8.4 Biomolecule Nanoarrays bu Block Copolymer Nanolithography 8.5 Application of Nanostructured Surfaces to Study Cell Adhesion 8.6 Conclusion Chapter 9. Responsive polymer coatings for smart applications in chromatography, drug delivery systems and cell sheet engineering Rogerio P. Pirraco, Masayuki Yamato, Yoshikatsu, Kenichi Nagase, Masamichi Nakayama, Alexandra P. Marques, Rui L. Reis and Teruo Okano 9.1 Introduction 9.2 Temperature-responsive chromatography 9.3 Temperature-responsive polymer micelle 9.4 Temperature-responsive culture surfaces 9.5 Cell sheet Engineering 9.6 Conclusions .
520 ▼a "This resource gives a comprehensive overview of surface modifications for applications in biotechnology using intelligent coatings. The coverage includes chemical properties, characterization methods, coating techniques, state-of-the-art examples, and an outlook on the promising future of this technology. It enables the interested materials scientist, chemist, or engineer to gain a comprehensive overview of the field, highlighting applications, with each chapter written by an expert in that particular area. Applications covered include tissue engineering, biotribology, drug targeting and delivery, wound healing, biosensors, nanopatterning, and bioinspired design of new smart materials and surfaces"-- ▼c Provided by publisher.
520 ▼a "This book gives a comprehensive overview of surface modifications for applications in biotechnology using intelligent coatings from metals to plastics, including materials chemical properties, characterization methods, coating techniques, state-of-the-art examples, and an outlook on the promising future of this technology. It enables the interested materials scientist, chemist, or engineer to gain a comprehensive overview of the field, highlighting applications of high-impact, with each chapter being written by an expert in that particular area"-- ▼c Provided by publisher.
650 0 ▼a Biomedical materials.
650 0 ▼a Biotechnology ▼x Materials.
650 0 ▼a Smart materials.
650 0 ▼a Surfaces (Technology)
700 1 ▼a Textor, Marcus.
700 1 ▼a Grandin, H. Michelle.
945 ▼a KLPA

Holdings Information

No. Location Call Number Accession No. Availability Due Date Make a Reservation Service
No. 1 Location Science & Engineering Library/Sci-Info(Stacks2)/ Call Number 610.284 I613 Accession No. 121218898 Availability Available Due Date Make a Reservation Service B M

Contents information

Table of Contents

Foreword xv

Preface xix

Contributors xxiii

1. Stimulus-Responsive Polymers as Intelligent Coatings for Biosensors: Architectures, Response Mechanisms, and Applications 1
Vinalia Tjong, Jianming Zhang, Ashutosh Chilkoti, and Stefan Zauscher

1.1 Introduction 1

1.2 SRP Architectures for Biosensor Applications 2

1.2.1 Cross-Linked Polymer Networks (Hydrogels) 2

1.2.2 End-Grafted Polymer Chains (Polymer Brushes) 5

1.2.3 Self-Assembled Polyelectrolyte (PEL) Multilayers (LBL Thin Films) 5

1.2.4 Molecularly Imprinted Polymers 6

1.2.5 Hybrid Coatings 6

1.3 Mechanisms of Response 6

1.3.1 Sensing Selectivity 6

1.3.2 Conformational Reorganization of SRP Coatings 7

1.3.2.1 Changes in Osmotic Swelling Pressure 7

1.3.2.2 Changes in Apparent Cross-Link Density 8

1.4 Sensing and Transduction Mechanisms 9

1.4.1 Optical Transduction 9

1.4.1.1 Examples of SRP Sensors That Use Optical Transduction Principles 11

1.4.2 Electrochemical Transduction 14

1.4.2.1 Examples of SRP Sensors That Use Electrochemical Transduction Principles 15

1.4.3 Mechanical Transduction 17

1.4.3.1 Examples of SRP Sensors That Use Mechanical Transduction Principles 18

1.5 Limitations and Challenges 19

1.5.1 LOD and Sensitivity 19

1.5.2 Selectivity 20

1.5.3 Working Range 20

1.5.4 Response Time 20

1.5.5 Reliability and Long-Term Stability 21

1.6 Conclusion and Outlook 22

Acknowledgements 22

References 22

2. Smart Surfaces for Point-of-Care Diagnostics 31
Michael A. Nash, Allison L. Golden, John M. Hoffman, James J. Lai, and Patrick S. Stayton

2.1 Introduction 31

2.1.1 POC Testing Challenges 32

2.2 Standard Methods for Biomarker Purification, Enrichment, and Detection 33

2.3 Smart Reagents for Biomarker Purification and Processing 34

2.3.1 IgG Antibody–pNIPAAm Conjugates 38

2.3.2 Single-Chain Antibody–pNIPAAm Conjugates 39

2.3.3 Nucleotide–pNIPAAm Conjugates 40

2.3.4 Magnetic Nanoparticle (mNP)–pNIPAAm Conjugates 40

2.3.5 Gold Nanoparticle (AuNP)–pNIPAAm Conjugates 42

2.4 Sample-Processing Modules for Smart Conjugate Bioassays 44

2.4.1 Grafting of pNIPAAm from Microchannel Surfaces 45

2.4.2 Grafting of pNIPAAm from Porous Membranes 48

2.4.3 Magnetic Processing Modules 51

2.5 Devices for Use in Smart Conjugate Bioassays 54

2.5.1 Lateral-Flow Immunochromatography Devices 55

2.5.2 Wicking Membrane Flow-Through Devices 56

2.5.3 Polylaminate Microfl uidic Devices 57

2.5.4 Multilayer PDMS Smart Microfl udic Devices 58

2.6 Conclusions 60

References 61

3. Design of Intelligent Surface Modifications and Optimal Liquid Handling for Nanoscale Bioanalytical Sensors 71
Laurent Feuz, Fredrik Höök, and Erik Reimhult

3.1 Introduction 71

3.2 Orthogonal Small (Nano)-Scale Surface Modification Using Molecular Self-Assembly 75

3.2.1 Surface Anchor: How to Define and Retain a Molecular Pattern 77

3.2.1.1 Weak Anchors: “Physisorption” 77

3.2.1.2 Strong Anchors: “Chemisorption” 79

3.2.1.3 Weak versus Strong Anchors for Nanoscale Sensors 80

3.2.2 Spacer: How to Suppress Binding 83

3.2.3 Recognizing and Capturing Analytes on an Intelligent Nanostructure 86

3.2.3.1 Antibodies 86

3.2.3.2 Antibody Fragments 87

3.2.3.3 Aptamers 87

3.2.3.4 General Considerations for Recognition Element Immobilization 87

3.3 Alternative Surface Patterning Strategies 89

3.3.1 Lithographic Patterning of Physisorbed Macromolecules 89

3.3.2 Nanoscale Molecular Surface Modification through Printing 90

3.3.3 Nanoscale Molecular Surface Modification through Direct Writing 91

3.3.4 Multivalency and the Intelligent Fluid Biointerface 92

3.3.5 Summary Functionalization of Nanoscale Biosensors 95

3.4 The Challenge of Analyte Transport 95

3.4.1 Convective versus Diffusive Flux ( jC vs. jD) 98

3.4.1.1 Scenario A ( jC = 0) 99

3.4.1.2 Scenario B ( jC = jD) 101

3.4.1.3 Scenario C ( jC > jD) 102

3.4.1.4 Summary of Scenarios A, B, and C 103

3.4.2 Reactive versus Diffusive Flux ( jR vs. jD) 106

3.4.3 Design and Operation Criteria for Efficient Mass Transport 108

3.5 Concluding Remarks 112

References 113

4. Intelligent Surfaces for Field-Effect Transistor-Based Nanobiosensing 123
Akira Matsumoto, Yuji Miyahara, and Kazunori Kataoka

4.1 Introduction 123

4.2 FET-Based Biosensors 124

4.2.1 Metal–Insulator–Semiconductor (MIS) Capacitors 124

4.2.2 Principles of bio-FETs 125

4.2.3 Ion-Sensitive Field-Effect Transistors (ISFETs) and Their Direct Coupling with Various Biorecognition Elements as a Conventional Approach to bio-FETs 126

4.3 Intelligent Surfaces for Signal Transduction and Amplification of bio-FETs 128

4.3.1 CNT-Mediated Signal Transduction 128

4.3.2 SAM-Assisted Detection 129

4.3.3 Stimuli-Responsive Polymer Gel-Based Interfaces for “Debye Length-Free” Detection 130

4.4 New Targets of bio-FETs 132

4.4.1 Carbohydrate Chain Sialic Acid (SA) Detection Using PBA SAM-Modifi ed FETs 132

4.4.2 Scent Detection Using “Beetle/Chip” FETs 134

4.4.3 Aptamer-Modifi ed Biorecognition Surfaces for a Universal Platform of bio-FETs 134

4.5 Future Perspective 135

References 136

5. Supported Lipid Bilayers: Intelligent Surfaces for Ion Channel Recordings 141
Andreas Janshoff and Claudia Steinem

5.1 Introduction 141

5.2 Supported Lipid Bilayers 142

5.2.1 SSMs on Flat Interfaces 142

5.2.1.1 Lipid Bilayers on Transparent Surfaces 143

5.2.1.2 Lipid Bilayers on Gold Surfaces 143

5.2.1.3 Lipid Bilayers on Silicon 145

5.2.2 SSMs on Porous/Aperture Containing Surfaces 146

5.2.2.1 Lipid Bilayers on Micromachined Apertures 146

5.2.2.2 Lipid Bilayers on Porous Materials 147

5.2.3 Patterning of SSMs 148

5.2.3.1 Patterning of Hybrid SSMs 149

5.2.3.2 Patterning of Nonhybrid SSMs 149

5.3 Characteristics of SSMs 151

5.3.1 Thermomechanical Properties of SSMs 151

5.3.2 Mechanical Stability 154

5.4 Ion Channels in SSMs 157

5.4.1 Carriers 158

5.4.2 Channel-Forming Peptides 158

5.4.3 Channel-Forming Proteins 162

5.5 Future Perspective: Ion Channels in Micropatterned Membranes 163

References 172

6. Antimicrobial and Anti-Inflammatory Intelligent Surfaces 183
Hans J. Griesser, Heike Hall, Toby A. Jenkins, Stefani S. Griesser, and Krasimir Vasilev

6.1 Introduction 183

6.2 Antibacterial Strategies 184

6.2.1 The Infection Problem 184

6.2.2 Approaches to Antibacterial Device Surfaces 186

6.2.3 Release of Antimicrobial Compounds from Polymers and Polymeric Coatings 190

6.2.4 Silver-Releasing Coatings 191

6.2.5 Nonfouling Coatings 196

6.2.6 Surface-Grafted Antibacterial Molecules 196

6.3 Bioactive Antibacterial Surfaces 198

6.3.1 Established, Commercially Available Antibiotics 198

6.3.2 Experimental Antibiotics 201

6.4 Stimulus-Responsive Antibacterial Coatings for Wound Dressings 204

6.5 Anti-Infl ammatory Surfaces 208

6.5.1 The Infl ammatory Response 208

6.5.2 Contact Activation of the Complement System 209

6.5.3 Foreign Body Reaction 211

6.5.4 Anti-infl ammatory Medication 212

6.5.5 Local Prevention of the Infl ammatory

Reaction on Medical Device/Implant Surfaces 215

6.5.5.1 Prevention of Contact Activation of the Complement System 215

6.5.5.2 Prevention of the Foreign Body Reaction by Preventing Macrophage Adhesion and Fusion 216

6.5.5.3 Prevention of Inflammation on Material Surfaces by the Release of NO 217

6.5.5.4 Reduction of the Inflammatory Response by Increasing Hemocompatibility 220

6.6 Conclusions and Outlook 224

References 226

7. Intelligent Polymer Thin Films and Coatings for Drug Delivery 243
Alexander N. Zelikin and Brigitte Städler

7.1 Introduction 243

7.2 Surface-Mediated Drug Delivery 246

7.2.1 Controlled Cell Adhesion and Proliferation 247

7.2.2 Small Cargo 254

7.2.3 Delivery and Presentation of Protein and Peptide Cargo 257

7.2.4 Delivery of Gene Cargo 261

7.3 Drug Delivery Vehicles with Functional Polymer Coatings 268

7.3.1 Core–Shell Particles 268

7.3.2 Polymer Capsules 271

7.4 Concluding Remarks 280

References 280

8. Micro- and Nanopatterning of Active Biomolecules and Cells 291
Daniel Aydin, Vera C. Hirschfeld-Warneken, Ilia Louban, and Joachim P. Spatz

8.1 Introduction 291

8.2 Chemical Approaches for Protein Immobilization 291

8.3 Biomolecule Patterning by “Top-Down” Techniques 294

8.3.1 Microcontact Printing (μCP) 294

8.3.2 Nanoimprint Lithography (NIL) 294

8.3.3 Electron Beam Lithography (EBL) 295

8.3.4 Dip-Pen Nanolithography (DPN) 295

8.4 Biomolecule Nanoarrays by Block Copolymer Nanolithography 296

8.4.1 Block Copolymer Nanolithography 297

8.4.2 Biofunctionalization of Nanostructures 299

8.4.3 Hierarchically Nanostructured Biomolecule Arrays 300

8.4.4 Fabrication of Nanoscale Distance Gradients 302

8.4.5 Soft Polymeric Biomolecule Arrays 303

8.5 Application of Nanostructured Surfaces to Study Cell Adhesion 305

8.5.1 Mimicking the Extracellular Environment 305

8.5.2 Nanoscale Control of Cellular Adhesion 305

8.5.3 Micro-Nanopatterns to Uncouple Local from Global Density 307

8.5.4 Nanoscale Gradients to Induce Cell Polarization and Directed Migration 309

8.5.5 Substrate Elasticity Determines Cell Fate 311

8.6 Conclusion 313

References 313

9. Responsive Polymer Coatings for Smart Applications in Chromatography, Drug Delivery Systems, and Cell Sheet Engineering 321
Rogério P. Pirraco, Masayuki Yamato, Yoshikatsu Akiyama, Kenichi Nagase, Masamichi Nakayama, Alexandra P. Marques, Rui L. Reis, and Teruo Okano

9.1 Introduction 321

9.2 Temperature-Responsive Chromatography 322

9.2.1 Hydrophobic Chromatography 322

9.2.2 Ion-Exchange Chromatography 324

9.2.3 Affinity Chromatography 327

9.3 Temperature-Responsive Polymer Micelles 328

9.3.1 Temperature-Responsive Corona 329

9.3.2 Temperature-Responsive Core 332

9.4 Temperature-Responsive Culture Surfaces 333

9.4.1 Temperature-Responsive Culture Dishes 333

9.4.2 Temperature-Responsive Surfaces on Porous Substrates 336

9.4.3 Functionalization of Temperature-Responsive Surfaces 336

9.4.4 Temperature-Responsive Surface Patterning 338

9.5 Cell Sheet Engineering 339

9.5.1 Characterization of Harvested Cell Sheets 339

9.5.2 Applications in Regenerative Medicine 340

9.5.3 Thick Tissue Reconstruction 343

9.6 Conclusions 345

References 346

Index 355


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