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Molecular and cell biology of neuropsychiatric diseases

Molecular and cell biology of neuropsychiatric diseases

Material type
단행본
Personal Author
Owen, Frank. Itzhaki, Ruth.
Title Statement
Molecular and cell biology of neuropsychiatric diseases / edited by Frank Owen and Ruth Itzhaki.
Publication, Distribution, etc
London :   Chapman & Hall,   1994.  
Physical Medium
x, 201 p. : ill. ; 27 cm.
Series Statement
Molecular and cell biology of human diseases series ;4
ISBN
0412478005 (acid-free paper)
Bibliography, Etc. Note
Includes bibliographical references and index.
Subject Added Entry-Topical Term
Nervous system -- Degeneration -- Molecular aspects. Neuropsychiatry. Alzheimer Disease. Bipolar Disorder. Genetics, Biochemical. Huntington's Disease. Schizophrenia.
비통제주제어
Humans , Nervous system , Diseases ,,
000 01208camuu2200337 a 4500
001 000045654372
005 20110714144916
008 930819s1994 enka b 001 0 eng c
020 ▼a 0412478005 (acid-free paper)
035 ▼a (KERIS)BIB000008033475
040 ▼a 211042 ▼c 211042 ▼d 211009
082 0 4 ▼a 616.8 ▼2 22
084 ▼a 616.8 ▼2 DDCK
090 ▼a 616.8 ▼b M718
245 0 0 ▼a Molecular and cell biology of neuropsychiatric diseases / ▼c edited by Frank Owen and Ruth Itzhaki.
246 3 ▼a Molecular & cell biology of neuropsychiatric diseases
260 ▼a London : ▼b Chapman & Hall, ▼c 1994.
300 ▼a x, 201 p. : ▼b ill. ; ▼c 27 cm.
440 0 ▼a Molecular and cell biology of human diseases series ; ▼v 4
504 ▼a Includes bibliographical references and index.
650 0 ▼a Nervous system ▼x Degeneration ▼x Molecular aspects.
650 0 ▼a Neuropsychiatry.
650 1 2 ▼a Alzheimer Disease.
650 2 2 ▼a Bipolar Disorder.
650 2 2 ▼a Genetics, Biochemical.
650 2 2 ▼a Huntington's Disease.
650 2 2 ▼a Schizophrenia.
653 0 ▼a Humans ▼a Nervous system ▼a Diseases
700 1 ▼a Owen, Frank.
700 1 ▼a Itzhaki, Ruth.

Holdings Information

No. Location Call Number Accession No. Availability Due Date Make a Reservation Service
No. 1 Location Medical Library/Monographs(3F)/ Call Number 616.8 M718 Accession No. 131040919 Availability Available Due Date Make a Reservation Service B M

Contents information

Table of Contents


CONTENTS
List of contributors = ⅸ
1 Molecular biology Of Huntington'S disease / DAVID CRAUFURD = 1
 1.1 Introduction = 1
 1.2 Linkage analysis = 1
 1.3 Recombination events = 3
 1.4 Linkage disequilibrium = 5
 1.5 Genomic imprinting = 6
 1.6 Predictive testing = 9
 1.7 Ethical considerations = 11
 1.8 Uptake of predictive testing = 13
 1.9 Counselling = 15
 1.10 Conclusion = 17
References = 19
2 Neuronal pathology in relation to molecular biology and treatment of alzheimer's disease / PAUL T. FRANCIS ; and DAVID M. BOWEN = 25
 2.1 Introduction = 25
 2.2 Neurotransmission = 28
 2.3 Glutamate, excitotoxicity and -amyloid = 36
 2.4 Drug therapies = 38
 2.5 Conclusions = 43
References = 44
3 The aetiology of Alzheimer'S Disease / RUTH F. ITZHAKI = 55
 3.1 General introduction = 55
 3.2 Aluminium = 55
 3.3 Viruses = 72
 3.4 DNA repair = 76
 3.5 Other possible risk factors = 80
 3.6 Epilogue = 81
Acknowledgements = 82
References = 82
4 The molecular genetics of Alzheimer'S disease / MICHAEL J.OWEN = 92
 4.1 Introduction = 92
 4.2 Genetic epidemiology = 94
 4.3 The molecular genetics of Alzheimer's disease = 98
 4.4 Future studies = 104
References = 105
5 The molecular biology of the transmissible dementias / FRANK OWEN = 110
 5.1 Introduction = 110
 5.2 The infectious agent = 111
 5.3 The PrP gene and its expression = 112
 5.4 The PrP = 113
 5.5 Molecular genetics of the human transmissible dementias = 116
 5.6 Summary and concluding remarks = 126
References = 126
6 The neurochemistry of schizophrenia / FRANK OWEN ; and MICHAEL SIMPSON = 133
 6.1 Serotonergic function in schizophrenia = 133
 6.2 Central noradrenergic function in schizophrenia = 135
 6.3 Dopamine and schizophrenia = 136
 6.4 Monoamine oxidase and schizophrenia = 139
 6.5 GABAergic function in schizophrenia = 141
 6.6 Neuropeptidergic function in schizophrenia = 141
 6.7 Glutamatergic systems in schizophrenia = 144
 6.8 Conclusions = 148
References = 148
7 Molecular biology of schizophrenia / DAVID ST CLAIR ; WALTER MUIR ; and DOUGLAS BLACKWOOD = 160
 7.1 Introduction = 160
 7.2 Linkage studies = 165
 7.3 Cytogentic anomalies and schizophrenia = 166
 7.4 Mutation analysis in schizophrenia = 168
 7.5 Summary = 169
References = 169
8 Genetics and molecular biology of manic-depression / MICHAEL GILL = 173
 8.1 Introduction = 173
 8.2 Clinical diagnosis and identification of the phenotype = 174
 8.3 Clinical genetics and models of transmission = 176
 8.4 Models of genetic transmission = 179
 8.5 Biological theories and possible candidate genes = 180
 8.6 Gene finding methods : genetic linkage and allelic association = 184
 8.7 Genetic(allelic) association analysis and its use in the major psychoses = 187
References = 189
Index = 194


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