CONTENTS
List of contributors = ⅸ
1 Molecular biology Of Huntington'S disease / DAVID CRAUFURD = 1
1.1 Introduction = 1
1.2 Linkage analysis = 1
1.3 Recombination events = 3
1.4 Linkage disequilibrium = 5
1.5 Genomic imprinting = 6
1.6 Predictive testing = 9
1.7 Ethical considerations = 11
1.8 Uptake of predictive testing = 13
1.9 Counselling = 15
1.10 Conclusion = 17
References = 19
2 Neuronal pathology in relation to molecular biology and treatment of alzheimer's disease / PAUL T. FRANCIS ; and DAVID M. BOWEN = 25
2.1 Introduction = 25
2.2 Neurotransmission = 28
2.3 Glutamate, excitotoxicity and -amyloid = 36
2.4 Drug therapies = 38
2.5 Conclusions = 43
References = 44
3 The aetiology of Alzheimer'S Disease / RUTH F. ITZHAKI = 55
3.1 General introduction = 55
3.2 Aluminium = 55
3.3 Viruses = 72
3.4 DNA repair = 76
3.5 Other possible risk factors = 80
3.6 Epilogue = 81
Acknowledgements = 82
References = 82
4 The molecular genetics of Alzheimer'S disease / MICHAEL J.OWEN = 92
4.1 Introduction = 92
4.2 Genetic epidemiology = 94
4.3 The molecular genetics of Alzheimer's disease = 98
4.4 Future studies = 104
References = 105
5 The molecular biology of the transmissible dementias / FRANK OWEN = 110
5.1 Introduction = 110
5.2 The infectious agent = 111
5.3 The PrP gene and its expression = 112
5.4 The PrP = 113
5.5 Molecular genetics of the human transmissible dementias = 116
5.6 Summary and concluding remarks = 126
References = 126
6 The neurochemistry of schizophrenia / FRANK OWEN ; and MICHAEL SIMPSON = 133
6.1 Serotonergic function in schizophrenia = 133
6.2 Central noradrenergic function in schizophrenia = 135
6.3 Dopamine and schizophrenia = 136
6.4 Monoamine oxidase and schizophrenia = 139
6.5 GABAergic function in schizophrenia = 141
6.6 Neuropeptidergic function in schizophrenia = 141
6.7 Glutamatergic systems in schizophrenia = 144
6.8 Conclusions = 148
References = 148
7 Molecular biology of schizophrenia / DAVID ST CLAIR ; WALTER MUIR ; and DOUGLAS BLACKWOOD = 160
7.1 Introduction = 160
7.2 Linkage studies = 165
7.3 Cytogentic anomalies and schizophrenia = 166
7.4 Mutation analysis in schizophrenia = 168
7.5 Summary = 169
References = 169
8 Genetics and molecular biology of manic-depression / MICHAEL GILL = 173
8.1 Introduction = 173
8.2 Clinical diagnosis and identification of the phenotype = 174
8.3 Clinical genetics and models of transmission = 176
8.4 Models of genetic transmission = 179
8.5 Biological theories and possible candidate genes = 180
8.6 Gene finding methods : genetic linkage and allelic association = 184
8.7 Genetic(allelic) association analysis and its use in the major psychoses = 187
References = 189
Index = 194
