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Biochemistry of exercise and training

Biochemistry of exercise and training (3회 대출)

자료유형
단행본
개인저자
Maughan, Ron J. , 1951-. Gleeson, Michael 1948- Greenhaff, Paul L.
서명 / 저자사항
Biochemistry of exercise and training / Ron J. Maughan, Michael Gleeson, and Paul L. Greenhaff.
발행사항
British Indian Ocean Territory ;   New York :   Oxford University Press ,   1997.  
형태사항
xxii, 234 p. : ill. ; 24 cm.
총서사항
Oxford medical publications
ISBN
0192627414 (pbk.)
서지주기
Includes bibliographical references and index.
일반주제명
Exercise -- Physiological aspects. Sports -- Physiological aspects. Biochemistry. Metabolism. Exercise -- physiology. Sports -- physiology. Biochemistry. Metabolism.
000 01131namuu2200313 a 4500
001 000045262116
005 20060601135432
008 001205s1997 bi a b aeng c
020 ▼a 0192627414 (pbk.)
040 ▼a 211010 ▼c 211010 ▼d 211010 ▼d 211010
082 0 0 ▼a 612/.044 ▼2 21
090 ▼a 612.044 ▼b M449b
100 1 ▼a Maughan, Ron J. , ▼d 1951-.
245 1 0 ▼a Biochemistry of exercise and training / ▼c Ron J. Maughan, Michael Gleeson, and Paul L. Greenhaff.
260 ▼a British Indian Ocean Territory ; ▼a New York : ▼b Oxford University Press , ▼c 1997.
300 ▼a xxii, 234 p. : ▼b ill. ; ▼c 24 cm.
440 0 ▼a Oxford medical publications
504 ▼a Includes bibliographical references and index.
650 0 ▼a Exercise ▼x Physiological aspects.
650 0 ▼a Sports ▼x Physiological aspects.
650 0 ▼a Biochemistry.
650 0 ▼a Metabolism.
650 1 2 ▼a Exercise ▼x physiology.
650 2 2 ▼a Sports ▼x physiology.
650 2 2 ▼a Biochemistry.
650 2 2 ▼a Metabolism.
700 1 ▼a Gleeson, Michael ▼d 1948-
700 1 ▼a Greenhaff, Paul L.

소장정보

No. 소장처 청구기호 등록번호 도서상태 반납예정일 예약 서비스
No. 1 소장처 의학도서관/보존서고3/ 청구기호 612.044 M449b 등록번호 141007669 도서상태 대출가능 반납예정일 예약 서비스 B M

컨텐츠정보

목차


CONTENTS

List of abbreviations = xiii

Biochemical terminology = xix

1 Physiology and biochemistry of skeletal muscle and exercise = 1

 1.1 The physiology and biochemistry of exercise = 1

 1.2 Skeletal muscle = 1

  1.2.1 Structure, innervation, and blood supply = 2

  1.2.2 Muscle fibre ultrastructure = 3

  1.2.3 Molecular composition of the myofilaments = 5

  1.2.4 The mechanism of force development = 6

  1.2.5 Control of force development = 8

  1.2.6 Motor units = 8

  1.2.7 Fibre types = 10

  1.2.8 Types of muscle action = 14

  1.2.9 Plasticity of skeletal muscle = 15

 1.3 Sources of energy for muscle contraction = 15

  1.3.1 ATP = 15

  1.3.2 Anaerobic metabolism = 17

  1.3.3 Phosphagen system = 17

  1.3.4 Glycolytic system = 18

  1.3.5 Aerobic metabolism : oxidation of carbohydrate, lipid, and protein = 19

 1.4 Tricarboxylic acid cycle = 20

 1.5 Electron transport chain = 23

 1.6 Oxidative phosphorylation = 26

 1.7 Carbohydrate and lipid stores = 27

 1.8 Methods of estimating substrate use = 28

 1.9 Factors influencing the utilization of fuel sources during exercise = 29

  1.9.1 Intensity and duration of exercise = 29

  1.9.2 Muscle fibre type composition = 31

  1.9.3 diet and feeding during exercise = 31

  1.9.4 Exercise training = 31

  1.9.5 Prior exercise = 32

  1.9.6 Drugs = 32

  1.9.7 Hormones = 32

  1.9.8 Environental factors = 33

 1.10 Delivery of blood-borne fuel and oxygen to muscle during exercise = 34

  1.10.1 Blood flow distribution = 34

  1.10.2 Cardiac output and venous return = 36

  1.10.3 Blood volume = 37

  1.10.4 Blood pressure = 38

  1.10.5 Pulmonary ventilation = 39

  1.10.6 Blood oxygen-carrying capacity = 41

 1.11 Oxygen uptake by muscle during exercise = 42

  1.11.1 Limitations to oxygen uptake during exercise = 43

 1.12 Key points = 45

 Further reading = 46

 References = 46

2 Purine nucleotides and phosphocreatine = 47

 2.1 Free energy = 47

 2.2 Adenosine triphosphate(ATP) and phosphocreatine(PCr) = 48

 2.3 The free energy charge and the adneylate pool = 52

 2.4 Skeletal muscle adenine nucleotide loss = 55

 2.5 The purine nucleotide cycle = 57

  2.5.1 Deamination in the purine nucleotide cycle = 57

  2.5.2 Reamination in the purine nucleotide cycle = 57

  2.5.3 Fatigue = 60

 2.6 Key points = 60

 Further reading = 61

 References = 62

3 Carbohydrate metabolism = 63

 3.1 Role of carbohydrates = 63

 3.2 Carbohydrate supply = 63

 3.3 The reactions of anaerobic glycolysis and glycogenolysis = 65

 3.4 Regeneration of NA$$D^+$$ = 69

 3.5 Regulation of glycolysis = 72

 3.6 Carbohydrate utilization in different tissues = 75

 3.7 Gluconeogenesis : formation of glucose from non-carbohydrate sources = 77

 3.8 Glycogen synthesis = 79

 3.9 Hormonal control of carbohydrate metabolism = 81

 3.10 Methodology and advances in the study of carbohydrate metabolism = 84

 3.11 Key points = 85

 Further reading = 86

 References = 87

4 Kipid metabolism = 88

 4.1 Role of lipids = 88

 4.2 Types of lipids = 88

  4.2.1 Simple lipids = 88

  4.2.2 Compound lipids = 91

  4.2.3 Derived lipids = 94

 4.3 Lipid synthesis = 94

  4.3.1 Ftty acid synthesis = 94

  4.3.2 Triacylglycerol synthesis = 98

 4.4 Lipolysis = 100

 4.5 Oxidation of fatty acids = 102

 4.6 Intramuscular triacylglycerol = 107

 4.7 ketone body formation and oxidation = 108

 4.8 The regulation of lipid metabolism during exercise = 109

 4.9 The influence of endurance training on lipid metabolism during exercise = 112

 4.10 Key points = 112

 Further reading = 113

 References = 113

5 Metabolism of protein, amino acids, and related molecules = 114

 5.1 Role of proteins = 114

 5.2 Amino acids = 114

 5.3 Protein structure and function = 117

 5.4 Nucleic acids and control of protein synthesis = 118

 5.5 Protein turnover = 122

 5.6 Metabolism of amino acids = 123

 5.7 Protein metabolism in exercise = 126

 5.8 Gluconeogenesis and ketogenesis = 127

 5.9 Control of protein turnover = 129

 5.10 Biologically important amino acids and related compounds = 130

  5.10.1 Neurotransmitter amino acids = 131

 5.11 Regulatory peptides and proteins = 134

  5.11.1 Metabolic regulators = 134

  5.11.2 Growth factors = 135

  5.11.3 Gut peptides = 135

  5.11.4 Brain peptides = 135

 5.12 Key points = 136

 Further reading = 137

6 Metabolic responses to high-intensity exercise = 138

 6.1 ATP resynthesis = 138

 6.2 Substrates for high-intensity exercise = 138

  6.2.1 Phosphocreatine = 138

  6.2.2 Glycogenolysis and glycolysis = 140

 6.3 The integration of phocreatine and glycogen utilization during maximal short-duration exercise = 142

 6.4 High-intensity exercise lasting more than 30s = 143

 6.5 Repeated bouts of exercise = 144

 6.6 Muscle fibre type responses = 144

 6.7 Fatigue = 146

  6.7.1 Fatigue associated with disruption of the energy supply = 147

  6.7.2 Fatigue due to product inhibition = 149

  6.7.3 Fatigue due to factors preceding crossbirdge formation = 150

 6.8 Nutrition and maximal exercise performance = 150

 6.9 Key points = 153

 Further reading = 155

 References = 157

7 Metabolic responses to prolonged exercise = 158

 7.1 Fuels for prolonged exercise = 158

 7.2 The integration of carbohydrate and fat oxidation by skeletal muscle = 159

 7.3 Muscle carbohydrate availability, diet, and exercise = 163

 7.4 Liver carbohydrate availability, diet, and exercise = 166

 7.5 Carbohydrate ingestion immediately prior to exercise = 168

 7.6 Carbohydrate ingestion during exercise = 169

 7.7 The effect of increasing fat availability prior to exercise = 170

 7.8 Fatigue mechanisms = 172

 7.9 Key points = 173

 Further reading = 175

 References = 175

8 Metabolic adaptation to training = 177

 8.1 Principles of training = 177

 8.2 Adaptation to endurance training = 178

  8.2.1 Fibre type composition = 179

  8.2.2 Muscle capillary density = 180

  8.2.3 Muscle myoglobin content = 182

  8.2.4 Intramuscular fuel stores = 183

  8.2.5 Glycolytic capacity = 183

  8.2.6 Muscle mitochondrial density and oxidative enzyme activity = 184

 8.3 Modification of the metabolic response to exercise by endurance training = 186

 8.4 Physiological adaptations to endurance training influencing the metabolic response to exercise = 190

 8.5 Time course of endurance training adaptations and of detraining = 193

 8.6 Hormonal adaptations to endurance training = 193

 8.7 Adaptation to sprint and strength training = 196

 8.8 Mechanisms of muscular adaptations to training = 199

 8.9 Training adaptations in blood lipid levels = 201

 8.10 Immunosuppression associated with heavy training = 203

 8.11 Overtraining = 204

 8.12 Key points = 206

 Further reading = 207

 References = 207

Appendix 1 Chemical structure and bonding = 209

 A1.1 Chemical structure = 209

  A1.1.1 Constitutional isomers = 209

  A1.1.2 Geometric stereoisomers = 210

  A1.1.3 Optical stereoisomers = 211

 A1.2 Structures of sugar molecules = 212

Appendix 2 Enzyme kinetics and the regulation of reactions = 215

 A2.1 Mechanisms of enzyne action = 215

 A2.2 Enzyme kinetics = 217

  A2.2.1 Zero-, first- and second-order reactions = 219

 A2.3 Enzyme activity = 219

  A2.3.1 Factors influencing enzyme activity = 219

  A2.3.2 Coenzymes, prosthetic gorups, co-factors, and activators = 220

  A2.3.3 Competitive and non-competitive inhibitors = 221

  A2.3.4 Allosteric and covalent modulation = 221

  A2.3.5 Enzyme isoforms = 221

 References = 222

Appendix 3 Chemical buffers and control of the acid-base balance = 223

 A3.1 Definitions = 223

 A3.2 Background = 223

 A3.3 Buffers = 224

 A3.4 Responses to disturbances of the acid-base balance = 227

  A3.4.1 Buffering(primary) response = 227

  A3.4.2 Physiological(secondary) response = 229

 A3.5 'Normal values' and forms of acid-base disturbance = 230

Acknowledgement = 231

Index = 233



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