CONTENTS
PREFACE = xv
Ⅰ MANAGING HEALTH AND SAFETY RISKS = 1
1 MANAGEMENT LEADERSHIP AND EMPLOYEE INVOLVEMENT = 3
1.1 Introduction = 3
1.2 Occupational Safety and Health Administration Guidelines = 3
1.3 Policies = 4
1.4 Goals and Objectives = 5
1.5 Top Management Involvement = 6
1.6 Employee Involvement = 7
1.7 Responsibilities = 8
1.8 Authority and Resources = 8
1.9 Accountability = 9
1.10 Program Evaluation = 9
1.11 Conclusion =11
1.13 Bibliography = 11
Attachment 1 : Sample Laboratory Health and Safety Assessment Questionnaire = 12
2 HAZARD EVALUATION AND IDENTIFICATION = 24
2.1 Introduction = 24
2.2 Occupational Safety and Health Administration Guidelines = 25
2.3 Surveys = 25
2.4 Change Analysis = 29
2.5 Job Hazard Analysis = 30
2.6 Inspections = 30
2.7 Hazard Reporting = 31
2.8 Accident/Incident Investigation = 31
2.9 Trends Analysis of Injuries and Illnesses = 32
2.10 common Laboratory Hazards = 32
2.11 Hazard Analysis Reference Material = 32
2.12 Conclusion = 35
2.13 Bibliography = 35
Attachment 1 : OSHA Job Hazard Analysis Form = 36
Attachment 2 : Sample Laboratory Inspection Checklist = 37
Attachment 3 : Laboratory Incident Investigation Form = 44
3 RESPONSIBILITIES = 47
3.1 Introduction = 47
3.2 Responsibilities = 47
3.3 Conclusion = 50
Ⅱ LABORATORY HEALTH AND SAFETY ADMINISTRATIVE PROGRAMS = 53
4 DOCUMENTATION = 55
4.1 Introduction = 55
4.2 Suggested Laboratory Health and Safety Guidelines = 55
4.3 Implementation of Suggested Laboratory Health and Safety Guidelines = 57
4.4 Bibliography = 60
5 TRAINING = 61
5.1 Introduction = 61
5.2 Suggested laboratory Health and Safety Guidelines = 62
5.3 Health and Safety Training programs = 63
5.4 Record Keeping = 73
5.5 Responsibility for Training = 75
5.6 OSHA's Voluntary Training Guidelines = 76
5.7 Training Resources = 79
5.8 Bibliography = 80
6 MEDICAL SURVEILLANCE = 81
6.1 Introduction = 81
6.2 Suggested Laboratory Health and Safety Guidelines = 82
6.3 Medical Surveillance Programs = 82
6.4 Biological Monitoring = 88
6.5 Issues for program Implementation = 89
6.6 Bibliography = 92
7 CHEMICAL HYGIENE PROGRAM = 94
7.1 Introduction = 94
7.2 Overview of OSHA's Laboratiory Standard (29 CFR 1910.1450) = 95
7.3 Instituting a Chemical Hygiene Program = 101
7.4 Writing a Chemical Hygiene Plan = 105
7.5 Designing a Chemical Hygiene Training Program = 106
7.6 Conclusion = 108
7.7 Bibliography = 108
Attachment 1 : Outline for Model Chemical Hygiene Plan = 109
Attachment 2 : Outline for Model Chemical Hygiene Training Program = 110
Ⅲ HAZARD EVALUATION AND IDENTIFICATION = 115
8 CHEMICAL EXPOSURE EVALUATION = 117
8.1 Introduction = 117
8.2 Suggested Laboratory Health and Safety Guidelines = 118
8.3 Implementation of Suggested Laboratory Health and Safety Guidelines = 118
8.4 Bibliography and Equipment References = 126
9 BIOSAFETY = 133
9.1 Introduction = 133
9.2 Suggested Laboratory Health and Safety Guidelines = 134
9.3 CDC/NIH Guidelines-scope and Application = 134
9.4 Research Involving Recombinant DNA = 137
9.5 Identification of Hazards/Classification of Organisms = 140
9.6 OSHA Blood-Borne Pathogen Standard-Scope and Application = 142
9.7 Bibliography = 147
Attachment 1 : Laboratory Biosafety level Criteria = 148
Attachment 2 : Classification of Microorganisms on the Basis of Hazard = 169
10 RADIATION = 174
10.1 Introduction = 174
10.2 Suggested Laboratory Health and Safety Guidelines = 175
10.3 United Sates Nuclear Regulatory Commission = 175
10.4 transportation Regulations = 178
10.5 Implementation of Suggested Laboratory Health and Safety Guidelines - Developement of a Pradiation Protection Program = 178
10.6 Nonionizing Radiation = 190
10.7 Bibliography = 193
Attachment 1 : Suggested Equipement and Suppliers = 194
Attachment 2 : Sample preparedness and procedures Statement Form = 195
Attachment 3 : Laser Survey Form = 197
11 CONTROLLED SUBSTANCES MANAGEMENT = 198
11.1 Introduction = 198
11.2 Schedule of Controlled Substances = 199
11.3 Activities Conducted with Controlled Substances = 201
11.4 Implementation of Requirements for Registration and Security = 202
11.5 additional Requirements = 204
11.6 Listed Chemicals and Certain Machines = 208
11.7 Importers and Exporters of Controlled Substances = 209
11.8 administrative Functions, Practices, and Procedures = 209
11.9 Further Information = 209
11.10 Bibliography = 209
12 ERGONOMICS PROGRAM MANAGEMENT = 211
12.1 Introduction = 211
12.2 Suggested Laboratory Health and Safety Guidelines = 212
12.3 Occupational Safety and Health Administration Recommendations = 212
12.4 Work Site Analysis = 213
12.5 Hazard Prevention and Control = 219
12.6 Medical Management = 224
12.7 Training and Education = 225
12.8 Bibliography = 225
13 WASTE MANAGEMENT = 227
13.1 Introduction = 227
13.2 suggested Laboratory Health and Safety Guidelines = 228
13.3 Regulatory Compliance = 228
13.4 Waste Management Practices/Methodologies(Waste Minimization) = 232
13.5 Radioactive Waste Management = 235
13.6 Biohazardous Waste Management = 238
13.7 Program Review = 241
13.8 Reference Guides = 242
13.9 Bibliography = 242
Ⅳ ENGINEERING CONTROLS = 243
14 GENERAL LABORATORY DESIGN = 245
14.1 Introduction = 245
14.2 Suggested Laboratory Health and Safety Guidelines = 245
14.3 How to Design General-Use Laboratories = 246
14.4 General Laboratory Construction = 253
14.5 Bibliography = 257
15 BARRIER SYSTEM DESIGN = 258
15.1 Introduction = 258
15.2 Overview of Barrier Design principles = 258
15.3 Suggested Laboratory Health and Safety Guidelines = 260
15.4 Implementation of Suggested Guidelines = 261
15.5 Fire Safety and Firefighting Considerations in Toxicological Laboratory Design = 268
15.6 Maintaining Structural Integrity = 270
15.7 Site Selection = 271
15.8 Bibliography = 272
16 BENTILATION = 274
16.1 Introduction = 274
16.2 Suggested Laboratory Health and Safety Guidelines = 275
16.3 Implementation of Suggested Laboratory Health and Safety Guidelines = 276
16.4 Bibliography = 295
Attachment 1 : Instructions for Monitoring Laboratory Hoods and Sample Monitoring Form = 296
Attachment 2 : Performance Tests = 298
Ⅴ PROTECTIVE EQUIPMENT AND WORK PRACTICE CONTROLS = 311
17 SAFETY SHOWERS AND EYEWASH STATIONS = 313
17.1 Introduction = 313
17.2 sugested Laboratory Health and Safety Guidelines = 313
17.3 Occupational Safety and Health Administration Requirements = 314
17.4 American National Standard Institute Recommendations = 314
17.5 suggested Manufacturers and Suppliers = 323
17.6 Bibliography = 324
18 PERSONAL PROTECTIVE EQUIPMENT = 325
18.1 Introduction = 325
18.2 Suggested Laboratory Health and Safety Guidelines = 326
18.3 Implementation of Suggested Laboratory Health and Safety Guidelines = 327
18.4 Effect of PPE on Job Performance = 334
18.5 Personal Protective Equipment Manufactures and Distributors = 336
18.6 Bibliography = 336
Attachment 1 : Protective Clothing Vendors = 338
19 RESPIRATORY PROTECTIVE EQUIPMENT = 348
19.1 Introduction = 348
19.2 Suggested Laboratory Health and Safety Guidelines = 349
19.3 Implementation of suggested Laboratory Health and Safety Guidelines = 350
19.4 record Keeping and documentation = 357
19.5 Bibliography = 358
Attachment 1 : Isoamyl Acetate (Banana Oil) Qualitative Fit Test Protocol = 358
Attachment 2 : Saccharin Solution Aerosol Qualitative Fit Test Protocal = 361
Attachment 3 : Irritant Smoke Qualitative Fit Test Protocal = 364
Attachment 4 : Respirator Quantitative Fit Test Procedures = 365
20 CHEMICAL HANDLING = 371
20.1 Introduction = 371
20.2 Suggested Laboratory Health and Safety Guidelines = 371
20.3 Overview of Chemical handling Principles = 372
20.4 Procurement, Receipt, and Distribution of Hazardous Chemical = 373
20.5 Chemical Storage = 373
20.6 Handling and Transport of Hazadous Chemicals = 375
20.7 Conclusion = 379
20.8 Bibliography = 379
21 FIRE AND EXPLOSION PROTECTION = 380
21.1 Introduction = 380
21.2 Suggested Laboratory Health and Safety Guidelines = 380
21.3 Implementation of /suggested Laboratory Health and Safety Guidelines = 382
21.4 Additional Guidance Inforamation = 386
21.5 Bibliography = 390
Attachment 1 : Manufacturers of Fire Protection Equipment = 390
Ⅵ EMERGENCY RESPONSE = 397
22 EMERGENCY RESPONSE = 399
22.1 Introduction = 399
22.2 Suggested Laboratory Health and Safety Guidelines = 399
22.3 Incidental Spill Cleanup = 400
22.4 Means of Egress = 402
22.5 Alarm Systems = 405
22.6 Emergency Power = 405
22.7 Emergency Medical Response = 407
22.8 Bibliography = 410
APPENDIXES
1 REGULATIONS OF PRIMARY CONCERN TO LABORATORIES = 411
2 GLOSSARY = 415
3 ADDTIONAL BIBLIOGRAPHY = 430
4 SUGGESTED LABORATORY HEALTH AND SAFETY GUIDELINES = 433
INDEX = 447
