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Principles of cellular and molecular immunology

Principles of cellular and molecular immunology (Loan 27 times)

Material type
단행본
Personal Author
Austyn, Jonathan M. Wood, Kathryn J.
Title Statement
Principles of cellular and molecular immunology / Jonathan M. Austyn and Kathryn J. Wood.
Publication, Distribution, etc
Oxford ;   New York :   Oxford University Press,   1992.  
Physical Medium
xi, 735 p. : ill. (some col.) ; 26 cm.
ISBN
0198542976 0198541953 (pbk.)
Bibliography, Etc. Note
Includes bibliographical references (p. 689-691) and index.
Subject Added Entry-Topical Term
Cellular immunity. Molecular immunology. Immunity. Immunity, Cellular. Molecular Biology.
000 01063camuu2200313 a 4500
001 000000916283
005 20141210094656
008 910318s1992 enka b 001 0 eng c
010 ▼a 91003127
020 ▼a 0198542976
020 ▼a 0198541953 (pbk.)
040 ▼a DNLM/DLC ▼c DLC ▼d DLC ▼d 244002 ▼d 211009
049 0 ▼l 151003370 ▼l 151002327
050 0 0 ▼a QR185.5 ▼b .A87 1993
082 0 0 ▼a 616.07/9 ▼2 23
084 ▼a 616.079 ▼2 DDCK
090 ▼a 616.079 ▼b A938p
100 1 ▼a Austyn, Jonathan M.
245 1 0 ▼a Principles of cellular and molecular immunology / ▼c Jonathan M. Austyn and Kathryn J. Wood.
260 ▼a Oxford ; ▼a New York : ▼b Oxford University Press, ▼c 1992.
300 ▼a xi, 735 p. : ▼b ill. (some col.) ; ▼c 26 cm.
504 ▼a Includes bibliographical references (p. 689-691) and index.
650 0 ▼a Cellular immunity.
650 0 ▼a Molecular immunology.
650 2 ▼a Immunity.
650 2 ▼a Immunity, Cellular.
650 2 ▼a Molecular Biology.
700 1 ▼a Wood, Kathryn J.

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No. 1 Location Science & Engineering Library/Sci-Info(Stacks2)/ Call Number 616.079 A938p Accession No. 521002919 Availability Available Due Date Make a Reservation Service B M
No. 2 Location Sejong Academic Information Center/Science & Technology/ Call Number 616.079 A938p Accession No. 151002327 Availability Available Due Date Make a Reservation Service M
No. 3 Location Sejong Academic Information Center/Science & Technology/ Call Number 616.079 A938p Accession No. 151003370 Availability Available Due Date Make a Reservation Service M
No. Location Call Number Accession No. Availability Due Date Make a Reservation Service
No. 1 Location Science & Engineering Library/Sci-Info(Stacks2)/ Call Number 616.079 A938p Accession No. 521002919 Availability Available Due Date Make a Reservation Service B M
No. Location Call Number Accession No. Availability Due Date Make a Reservation Service
No. 1 Location Sejong Academic Information Center/Science & Technology/ Call Number 616.079 A938p Accession No. 151002327 Availability Available Due Date Make a Reservation Service M
No. 2 Location Sejong Academic Information Center/Science & Technology/ Call Number 616.079 A938p Accession No. 151003370 Availability Available Due Date Make a Reservation Service M

Contents information

Table of Contents

CONTENTS
1 Introduction = 1
  1.1 General Features of the immune system = 3
    1.1.1 Immunity = 3
    1.1.2 Innate and adaptive immunity = 6
    1.1.3 Receptors, antigens, and lymphocyte antigen receptors = 29
    1.1.4 Self and non-self discrimination = 37
  1.2 An overview of immune responses = 39
    1.2.1 A map of cellular and molecular interactions during immune responses = 39
    1.2.2 Innate responses = 39
    1.2.3 Adaptive responses = 41
  1.3 Lymphoid tissues = 47
    1.3.1 Bone marrow origin of cells of the immune system = 47
    1.3.2 Primary and secondary lymphoid tissues = 51
    1.3.3 Lymphocyte recirculation = 52
    1.3.4 The structures of some lymphoid tissus = 55
  Futher reading = 61
2 The major histocompatibility complex = 63
  2.1 Introduction = 65
  2.2 General features of the MHC = 66
  2.3 Nomenclature = 66
  2.4 Cellular distribution of MHC molecules = 72
  2.5 Structure of MHC molecules = 72
    2.5.1 Class Ⅰ = 72
    2.5.2 Class Ⅱ = 84
  2.6 Biosynthesis and surface expression = 88
    2.6.1 Class Ⅰ molecules = 88
    2.6.2 Class Ⅱ molecules = 89
  2.7 Structure and regulation of expression of MHC genes = 93
    2.7.1 Class Ⅰ genes = 93
    2.7.2 Class Ⅱ genes = 94
  2.8 Genomic organization of the MHC = 96
    2.8.1 Class Ⅰ loci = 97
    2.8.2 Class Ⅱ loci = 101
  2.9 Mechanisms for the generation of polymorphisms = 105
    2.9.1 Generation of class Ⅰ polymorphisms = 106
    2.9.2 Generation of class Ⅱ polymorphisms = 108
    2.9.3 Selection pressure = 108
  2.10 Disease association = 109
  Further reading = 111
  Literature cited = 112
3 Antigen-presenting cells = 115
  3.1 Historical perspective = 117
  3.2 Antigen processing and presentation = 123
    3.2.1 T Cell recognition of processed antigens = 123
    3.2.2 Presentation of exogenous antigens by macrophocytes = 127
    3.2.3 Presentation of exogenous antigens by B lymphocytes = 140
    3.2.4 Presentation of endogenous antigens by fibroblasts and other cells = 143
  3.3 Peptide-MHC interactions = 145
    3.3.1 Presentation of exogenous and endogenous antigens by different MHC molecules = 145
    3.3.2 Intracellular sites of peptide-MHC associations = 146
    3.3.3 Binding of peptides to MHC molecules = 153
  3.4 Dendritic cells = 161
    3.4.1 Properties of dendritic cells = 162
    3.4.2 Distribution of dendritic cells and related cells = 165
    3.4.3 The role of dendritic cells in initiating immune responses = 168
    3.4.4 Antigen-presenting cell requirements for resting and activated T cells = 170
    3.4.5 Mechanism of dendritic cell stimulation = 172
  Further reading = 176
  Literature cited = 177
4 The molecular basis of T cell responses = 181
  4.1 Introduction = 183
  4.2 Membrance molecules in T cell responses = 189
    4.2.1 The αβ T cell receptor = 189
    4.2.2 The γδ T cell receptor = 192
    4.2.3 The CD3 complex = 197
    4.2.4 CD4 and CD8: interaction with MHC = 203
    4.2.5 CD45, the leukocyte common antigen: regulation of signal transduction = 213
    4.2.6 Integrins and selectins: cell adhesion and activation molecules = 218
    4.2.7 CD2: an alternative pathway for T cell activation = 227
    4.2.8 CD28: regulation of cytokine gene expression = 231
    4.2.9 Thy-1 = 233
  4.3 Expression of membrane molecules during T cell development = 234
  4.4 Cytokines and their receptors in T cell responses = 237
    4.4.1 Cytokines = 237
    4.4.2 Different T cells can produce different cytokines = 239
    4.4.3 Interleukin-2 and its receptor = 242
    4.4.4 Effects of other cytokines on T lymphocytes = 248
  Further reading = 251
  Literature cited = 253
5 The T cell repertoire = 257
  5.1 Introduction = 259
  5.2 Response of mature peripheral T cells to foreign antigens = 259
    5.2.1 Discovery of MHC restriction = 259
    5.2.2 Alloreactivity = 263
    5.2.3 Self-restriction and mechanisms of positive selection = 268
    5.2.4 Allorestriction = 276
    5.2.5 Self-tolerance and mechanisms of negative selection = 278
    5.2.6 The sequence of positive and negative selection in the thymus = 288
  5.3 Selection of the T cell repertoire during development = 291
    5.3.1 Introduction = 291
    5.3.2 The restriction specificity of T cells is acquired: studies with bone marrow chimeras = 291
    5.3.3 The restriction repertoire of helper T cells is determined in the thymus = 304
    5.3.4 The restriction repertoire of cytotoxic T cells can be determined outside of the thymus = 308
    5.3.5 The cells responsible for positive and negative selection in the thymus = 311
  5.4 Unresponsiveness of mature peripheral T cells to antigens under Ir gene control = 316
    5.4.1 MHC-linked immune response genes = 316
    5.4.2 Non-MHC-linked Ir genes = 320
    5.4.3 Function of MHC-linked Ir genes = 320
    5.4.4 Summary = 324
  Further reading = 325
  Literature cited = 326
6 Antigen receptors―structure and function = 329
  6.1 Introduction = 331
  6.2 Antibodies―B lymphocyte antigen receptors = 334
    6.2.1 Structure―an overview = 334
    6.2.2 Classification = 340
    6.2.3 Fine structure―hypervariable or complementarity determining regions = 346
    6.2.4 Functions = 348
    6.2.5 Relationship between structure and effector function = 358
    6.2.6 Biosynthesis and assembly = 368
    6.2.7 Level of expression of light chains in different species = 369
    6.2.8 ‘Designer antibodies’ = 370
  6.3 T cell antigen receptors = 372
    6.3.1 Structure = 372
    6.3.2 Function = 374
  Further reading = 381
  Literature cited = 382
7 Antigen receptor genes and the immunoglobulin superfamily = 385
  7.1 Introduction = 387
  7.2 Immunoglobulin genes = 388
    7.2.1 Organization = 389
    7.2.2 Rearrangement = 389
    7.2.3 Control of rearrangements and tissue-specific expression of Ig genes = 408
    7.2.4 Summary = 411
  7.3 T cell receptor genes = 413
    7.3.1 Organization = 413
    7.3.2 Rearrangement = 419
    7.3.3 Generation of T cell receptor diversity = 421
    7.3.4 Control of gene rearrangements = 423
  7.4 The immunoglobulin gene superfamily = 423
    7.4.1 Criteria for inclusion in the immunoglobulin superfamily = 425
    7.4.2 Members of the immunoglobulin superfamily = 427
    7.4.3 Evolution and possible significance of the immunoglobulin superfamily = 431
  Further reading = 433
  Literature cited = 434
8 B cells and antibody responses = 437
  8.1 Introduction = 439
  8.2 B cell development = 442
    8.2.1 Expression of antibody molecules during development of B cells = 442
    8.2.2 allelic exclusion of Ig genes = 443
    8.2.3 Other markers of B cell development = 446
    8.2.4 B cell lineages and subsets = 447
  8.3 Antibody responses to different types of antigen = 449
    8.3.1 T-dependent (TD) responses = 449
    8.3.2 T-independent (TI) responses = 464
    8.3.3 Responses to mitogens and polyclonal B cell activators = 466
    8.3.4 Overlaps in classification of antigens = 466
  8.4 B cell activation and B cell responses = 467
    8.4.1 Different phases in B cell responses = 467
    8.4.2 B cell activation = 469
    8.4.3 Control of B cell responses by cytokines = 475
    8.4.5 Two types of helper T cells and B cell responses = 489
  8.5 CD5-positives B cells = 489
    8.5.1 Distribution = 489
    8.5.2 Function = 491
  8.6 B cell tolerance = 492
    8.6.1 Clonal deletion = 493
    8.6.2 Clonal anergy = 494
  Further reading = 495
  Literature cited = 496
9 Inflammatory mediators and soluble effector mechanisms = 499
  9.1 Introduction = 501
  9.2 Inflammation = 501
    9.2.1 The response to injury and infection = 501
    9.2.2 The phases of inflammation = 504
    9.2.3 Mediators of inflammation = 506
  9.3 The plasma enzyme systems = 512
    9.3.1 The coagulation mechanism = 512
    9.3.2 Fibrinolysis = 517
    9.3.3 Kinin formation = 520
  9.4 Complement = 522
    9.4.1 Overview = 522
    9.4.2 Nomenclature = 522
    9.4.3 Activators of the complement cascade = 524
    9.4.4 The classical pathway―early events = 529
    9.4.5 The alternative pathway = 544
    9.4.6 Terminal components and formation of the membrance attack complex = 547
    9.4.7 Summary of the functions and control of the complement system = 551
    9.4.8 Genetics and biosynthesis of complement proteins = 553
  9.5 Cytokines mediating inflammatory and effector functions = 554
    9.5.1 Interleukin-1 and its receptor = 554
    9.5.2 Interleukin-6 and its receptor = 559
    9.5.3 Tumour necrosis factors and their receptor = 567
    9.5.4 Interferons = 572
  Further reading = 578
  Literature cited = 579
10 Cellular cytotoxicity = 581
  10.1 Introduction = 583
  10.2 Natural killer cells = 583
    10.2.1 Characteristics = 583
    10.2.2 Functions = 584
    10.2.3 Origin = 586
    10.2.4 Membrane molecules = 587
    10.2.5 NK cell lines and clones = 589
    10.2.6 Regulation of NK activity by cytokines = 590
    10.2.7 Antibody-dependent cellular cytotoxicity = 591
  10.3 Mechanisms of killing by NK cells and cytotoxic T cells = 593
    10.3.1 Phases of killing = 593
    10.3.2 Target cell recognition = 594
    10.3.3 Reorganization of cytoplasmic organelles = 598
    10.3.4 Delivery of the ‘lethal hit’ = 598
    10.3.5 Target cell death = 606
    10.3.6 Protection from self-lysis = 607
  10.4 Macrophages = 608
    10.4.1 Characteristics of macrophages = 609
    10.4.2 Resident macrophages = 612
    10.4.3 Inflammatory macrophages = 614
    10.4.4 Activated macrophages = 615
    10.4.5 Some macrophage receptors = 620
  10.5 Hypersensitivity = 633
    10.5.1 Type Ⅰ hypersensitivity = 634
    10.5.2 Type Ⅱ hypersensitivity = 635
    10.5.3 Type Ⅲ hypersensitivity = 635
    10.5.4 Type Ⅳ hypersensitivity = 635
  Further reading = 636
  Literature cited = 637
11 Idiotype networks and suppressor pathways = 641
  11.1 Idiotypes and idiotypic networks = 643
    11.1.1 Idiotypes of antibodies = 643
    11.1.2 Idiotypic networks = 654
    11.1.3 T cell idiotypes = 659
    11.1.4 Idiotypic regulation in vivo = 663
  11.2 Suppressor T cells and suppressor pathways = 670
    11.2.1 Immune suppression = 670
    11.2.2 Suppressor T cells = 671
    11.2.3 Suppressor factors = 679
    11.2.4 Accessory cells in suppressor pathways = 681
    11.2.5 Contrasuppression = 682
    11.2.6 Veto cells = 683
  11.3 Immune regulation by cytokines = 684
    Further reading = 687
    Literature cited = 688
Appendix: cellular and molecular techniques = 693
  A1 Production and use of antibodies = 695
    A1.1 Production and use of antisera = 695
    A1.2 Production of monoclonal antibodies = 696
    A1.3 Immunoprecipitation = 699
    A1.4 Immunocytochemistry = 702
    A1.5 Affinity chromatography = 704
    A1.6 Western blottin of immunoblotting = 705
    A1.7 Antibody-mediated complement-dependent cytotoxicity assay = 706
  A2 Cellular techniques = 707
    A2.1 Cell proliferation assays = 707
    A2.2 Cytotoxic T lymphocyte assay (CTL assay or 51 Cr release assay) = 709
    A2.3 Plaque-forming cell (PFC) assay = 711
  A3 Molecular techniques = 712
    A3.1 southern blotting: DNA-DNA hybridization analysis = 712
    A3.2 Northern blotting: RNA-DNA hybridization = 714
    A3.3 Polymerase chain reaction (PCR) = 715
    A3.4 DNA-mediated gene transfer (DMGT): gene transfection = 716
    A3.5 Production of transgenic mice = 717
    A3.6 Homologous recombination = 720
Index = 721

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