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Molecular mechanisms of immunological self-recognition

Molecular mechanisms of immunological self-recognition

자료유형
단행본
개인저자
Alt, Frederick W. Vogel, Henry J. (Henry James) , 1920-
서명 / 저자사항
Molecular mechanisms of immunological self-recognition / edited by Frederick W. Alt, Henry J. Vogel.
발행사항
San Diego :   Academic Press ,   c1993.  
형태사항
xiv, 259 p. : ill. ; 24 cm.
ISBN
0120537508
서지주기
Includes bibliographical references and index.
일반주제명
Immunological tolerance. Cellular recognition. T cells. B cells. Autoimmunity. B-Lymphocytes -- immunology. Cell Communication. Immune Tolerance. T-Lymphocytes -- immunology.
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010 ▼a 92049201
020 ▼a 0120537508
035 ▼a (KERIS)REF000014701624
040 ▼a DNLM/DLC ▼c DLC ▼d DLC ▼d 211009
050 0 0 ▼a QR188.4 ▼b .M65 1993
060 ▼a QW 568 M7186
082 0 4 ▼a 616.07/9 ▼2 22
090 ▼a 616.079 ▼b M7182
245 0 0 ▼a Molecular mechanisms of immunological self-recognition / ▼c edited by Frederick W. Alt, Henry J. Vogel.
260 ▼a San Diego : ▼b Academic Press , ▼c c1993.
300 ▼a xiv, 259 p. : ▼b ill. ; ▼c 24 cm.
504 ▼a Includes bibliographical references and index.
650 0 ▼a Immunological tolerance.
650 0 ▼a Cellular recognition.
650 0 ▼a T cells.
650 0 ▼a B cells.
650 2 ▼a Autoimmunity.
650 2 ▼a B-Lymphocytes ▼x immunology.
650 2 ▼a Cell Communication.
650 2 ▼a Immune Tolerance.
650 2 ▼a T-Lymphocytes ▼x immunology.
700 1 ▼a Alt, Frederick W.
700 1 ▼a Vogel, Henry J. ▼q (Henry James) , ▼d 1920-

소장정보

No. 소장처 청구기호 등록번호 도서상태 반납예정일 예약 서비스
No. 1 소장처 의학도서관/보존서고4/ 청구기호 616.079 M7182 등록번호 432005594 도서상태 대출가능 반납예정일 예약 서비스 B

컨텐츠정보

목차


CONTENTS
Preface = xiii
PARTⅠ INTRODUCTION
  Ⅰ Immunological Tolerance Revisited in the Molecular Era / G.J.V. NOSSAL
    The Dawn of Immunologic Tolerance = 3
    One Cell-One Antibody, and Implications = 5
    In Vitro Lymphocyte Cloning Techniques Validate Repertoire Purging as a Tolerance mechanism; Clonal Abotion versus Clonal Anergy = 7
    Clonal Abortion and Clonal Anergy Come of Age in the Molecular Era = 8
    The Genesis of High-Affinity Antibodies = 10
    Soluble Antigen Can Cause Adult Tolerance, Including a Failure of Appearance of High-Affinity Antibodies = 11
    Summary and Conclusions = 13
    References = 14
PARTⅡ B CELL TOLERANCE
  2 Mechanisms and Meaning of B Lymphocyte Tolerance / DAVID NEMAZEE
    Introduction = 19
    The Deletion-Anergy Decision = 19
    Consequences of Deletion versus Anergy = 21
    References = 22
  9 Recognition Requirements for the Positive Selection of the T Cell Repertoire: A Role of Self-Peptides and Major Histocompatibility Complex Pockets / JANKO NIKOLI \'C - Z ∨ UGI \'C ; MICHAEL J. BEVAN
    Introduction = 105
    Results and Discussion = 107
    Summary = 113
    References = 114
  10 Mechanisms of Peripheral Tolerance / G U ·· NTER J. H A ·· MMERLING ; G U ·· NTHER SCH O ·· NRICH ; FRANK MOMBURG ; MARIE MALISSEN ; ANNE-MARIE SCHMITT-VERHULST ; BERNARD MALISSEN ; BERND ARNOLD
    Introduction = 115
    Results = 116
    Distinct Mechanisms of Peripheral Tolerance = 118
    Conclusions = 120
    References = 121
  11 An Analysis of T Cell Receptor-Ligand Interaction Using a Transgenic Antigen Model for T Cell Tolerance and T Cell Receptor Mutagenesis / BARBARA FAZEKAS DE ST. GROTH ; PHILLIP A. PATTEN ; WILLIAM Y. HO ; EDWIN P. ROCK ; MARK M. DAVIS
    Introduction = 123
    T Cell Receptor Mutagenesis = 124
    A Paired Antigen/TCR Transgenic System = 125
    References = 127
  12 T Cell Repertoire and Tolerance / ANN M. PULLEN ; YOUGWON CHOI ; JOHN W. KAPPLER ; PHILIPPA MARRACK
    Introduction = 129
    Superantigens = 130
    Tolerance to Self-Superantigens Shapes the T Cell Repertoire = 131
    V β Interaction with the Self-Superantigen Mls-1 a = 132
    V β Interaction with the Foreign Superantigens = 133
    References = 135
  13 Sequential Occurrence of Positive and Negative Selection during T Lymphocyte Maturation / CYNTHIA J. GUIDOS ; IRVING L. WEISSMAN
    Introduction = 137
    Results and Discussion = 138
    References = 146
  14 Tolerance Induction in the Peripheral Immune System / MATT WISE ; RICHARD BENJAMIN ; SHIXIN QIN ; STEPHEN COBBOLD ; HERMAN WALDMANN
    Introduction = 149
    Materials and Methods = 150
    Results = 150
    Discussion = 153
    References = 155
PARTⅤ AUTOIMMUNITY
  15 Activation-Induced Cell Death of Effector T Cells: A Third Mechanism of Immune Tolerance / CHARLES A. JANEWAY, JR., ; YANG LIU
    Introduction = 159
    Experimental Results = 160
    Interpretations = 161
    References = 164
  16 T Cells Involved in Inductive Events in the Pathogenesis of Autoimmune Diabetes Mellitus / C. GARRISON FATHMAN ; JAYNE S. DANSKA ; ALEXANDRA M. LIVINGSTONE ; JUDITH A. SHIZURU
    Text = 165
    References = 171
  17 Genetic Control of Diabetes and Insulitis in the Nonobese Diabetic Mouse: Analysis of the NOD.H-2 b and B10.H-2 nod Strains / LINDA S. WICKER ; NICOLE H. DELARATO ; ALISON PRESSEY ; LAURENCE B. PETERSON
    Introduction = 173
    Materials and Methods = 175
    Results and Discussion = 176
    Concluding Remarks = 180
    References = 181
  18 Islet Tolerance in Humans and Transgenic Mice / NORA SARVETNICK
    Text = 183
    References = 186
  19 Fluorescence-Activated Cell Sorter Analysis of Peptide-Major Histocompatibility Complex / ANIMESH A. SINHA ; TIMOTHY A. MIETZENER ; CHRISTOPHER B. LOCK ; HUGH O. MCDEVITT
    Introduction = 187
    FACS Binding Assay = 188
    Results = 189
    Discussion = 191
    References = 192
  20 Tolerance to Self: A Delicate Balance / ELLEN HEBER-KATZ
    Introduction = 193
    Monoidiotypy = 194
    TCR-Specific Antibody Modulation of Disease = 194
    TCR Peptide Modulation = 195
    Discussion = 196
    References = 197
  21 Prevention, Suppression, and Treatment of Experimental Autoimmune Encephalomyelitis with a Synthetic T Cel Receptor V Region Peptide / HALINA OFFNER ; GEORGE HASHIM ; YUAN K. CHOU ; DENNIS BOURDETTE ; ARTHUR A. VANDENBARK
    Introduction = 200
    Animal Studies = 201
    Human Studies = 220
    Summary = 227
    References = 228
PARTⅥ PERSPECTIVES
  22 Tolerance of Self: Present and Future / N.A. MITCHISON
    The 1975 Baseline = 233
    F Liver Antigen = 235
    Negative Signaling = 236
    Anergy, and the Need for a Defined Anergic Phenotype = 237
    Thymus Lobe Cultures = 237
    Autoimmunity and Epitope Linkage = 238
    Toward Gene Therapy in Autoimmunity = 239
    References = 241
Index = 243

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