CONTENTS
Participants = ⅸ
Acknowledgements = xiii
Preface = xiv
Introduction = xv
Part One GENETIC ASPECTS
1 Risk of ovarian cancer associated with a family history / Preliminary report of theOPCS study B.A.J. Ponder, D.F. Easton ; J. Peto = 3
2 Hereditary ovarian cancer / H.T. Lynch, T. Conway ; J. Lynch = 7
3 Genetic perspectives in ovarian cancer / S. Kullander Discussion = 21
Part Two BIOLOGICAL ASPECTS Ⅰ
4 Ovarian cancer biology : progress and problems / W.F. Bodmer = 31
5 Animal models of ovarian cancer / F.R. Balkwill ; S.T.A. Malik ; D.B. Griffin Discussion = 37
6 New approaches in breast cancer research / R. Sager Discussion = 45
7 Regulatory mechanisms in ascitic fluid / G.B. Mills ; C. May = 55
8 The role of oncogenes in ovarian cancer / W.J. Gullick = 63
9 The prognostic value of steroid receptors, growth factors and growth factor receptors in ovarian cancer / R.E. Leake ; O. Owens Discussion = 69
Part Three BIOLOGICAL ASPECTS Ⅱ
10 Immunological control of ovarian caner / J.S. Berek ; J. Zighelboim ; Y. Nio ; B. Bonavida Discussion = 85
11 MHC expression on tumour cells / H. Festenstein ; J. Bridges ; C. Navarrete Discussion = 97
12 AgNOR counts in borderline ovarian tumours / W. Kinsey ; B. Randall ; L.J.R. Brown Discussion = 113
13 Flow cytometric quantitation of p6 2c-myc and DNA in serous papillary ovarian cancer / J.V. Watson ; O.M. Curling ; C.N. Hudson = 125
14 Drug resistance analysis in populations of individual cells using flow cytometry J.V. Watson ; S.A. Morgan ; C. Dive Discussion = 139
15 ras oncogene expression in advanced ovarian cancer / C.J. Rodenburg ; I.A. Koelma ; G.J. Fleuren Discussion = 159
16 The pathology of early malignant change / H. Fox = 165
Part Four EARLY DETECTION AND SCREENING
17 Intraperitoneal and retroperitoneal spread of ovarian cancer / H. Pickel ; M. Lagousen ; F. Girardi ; K. Tamussino ; H. Stettner Discussion = 171
18 Malignant potential of benign ovarian cysts : the case 'against' / H. Fox = 185
19 Malignant potential of benign ovarian cysts : the case 'for' / M.C. Anderson Discussion = 187
20 Potential screening tests for ovarian cancer / I.J. Jacobs ; D.A. Oram Discussion = 197
21 Tumour markers and the adnexal mass / W.T. Creasman ; J.T. Soper Discussion = 209
22 Developments in ultrasound screening for early ovarian cancer / S. Campbell ; W.P. Collins ; P. Royston ; T.H. Bourne ; V. Bhan ; M.I. Whitehead = 217
23 The evaluation of screening tests for ovarian cancer / H.S. Cuckle ; N.J. Wald Discussion = 229
24 Development of population-based studies of ovarian cancer screening / I.V. Scott ; A. Milford Ward ; C. Selby ; S. Whitehead ; M. Wilcox = 245
25 The value of a combination of tumour markers in ovarian cancer / M. Lahousen ; H. Stettner ; J. Haas ; P. P u ·· rstner = 259
26 Identification of markers for early detection of epithelial ovarian cancer / R.C. Bast Jr ; C.M. Boyer ; G.J. Olt ; A. Berchuck ; J.T. Soper ; D. Clarke-Pearson ; F.J. Xu ; S. Ramakrishman Discussion = 265
Part Five UPDATE ON POTENTIAL ADVANCES IN THERAPY
27 Future prospects for chemotherapy based on a dose intensity analysis / L. Levin = 281
28 Single versus multiple agent regimens / W.T. Creasman ; G.L. Eddy = 291
29 Single agent chemotherapy in ovarian cancer / S.B. Kaye Discussion = 299
30 High-dose chemotherapy with autologous bone marrow transplantation in epithelial ovarian cancer / F.G. Lawton ; N.F. Hacker = 309
31 Care of the patient with ovarian cancer : a quality of life perspective / A.D. DePetrillo ; L.J. Thompson = 315
32 Intraperitoneal therapy in ovarian cancer / G. Blackledge ; C.W.E. Redman ; D.M. Luesley = 323
33 Development of chemotherapeutic agents in ovarian cancer / D. Schm a ·· hl ; W.J. Zeller = 333
34 Cytokine therapy / S.A. Kelly ; S. Malik ; F.R. Balkwill = 337
35 Intraperitoneal interferon-alpha-2b for patients with a macroscopically negative second-look laparotomy. A preliminary report / N.F. Hacker ; F.G. Lawton ; L.K. Astbury ; R. Penny = 365
36 Initial experience with photodynamic therapy for intraperitoneal carcinomatosis / T.F. Delaney ; W. Sindelar ; P. Smith ; W. Friauf ; H. Pass ; A. Russo ; G. Thomas ; L. Dachowski ; J. Cole ; E. Glatstein Discussion = 371
37 Monoclonal antibodies to the polymorphic epithelial mucin / J. Burchell ; J. Taylor-Papadimitriou = 383
38 Intraperitoneal radioimmunotherapy with 90Y labelled monoclonal antibodies / V. Hird ; J.S.W. Sterwart ; C. Coulter ; H.E. Lambert ; W.P. Mason ; W.P. Soutter ; A.A. Epenetos = 391
39 The diagnostic and intraoperative use of monoclonal antibodies / E. Gitsch ; N. Pateisky Discussion = 399
Part Six UPDATE SURGICAL ASPECTS
40 The feasibility of optimal debulking surgery in ovarian cancer / J.M. Monaghan = 409
41 Cytoreductive surgery / A.P.M. Heintz Discussion = 413
42 The role of lymphadenectomy in ovarian cancer / E. Burghardt ; M. Lahousen ; H. Stettner = 425
43 Lymph node metastasis and survival in ovarian cancer / P.-C. Wu ; J.-H. Lang ; R.-L. Huang ; H. Wang ; M.-Y. Tang ; L.-J. Lian = 435
44 The value of lymphadenectomy in the management of ovarian cancer / F. Di Re ; R. Fontanelli ; F. Raspagliesi ; E.M. Di Re = 437
45 Lymph node metastases in epithelial ovarian cancer / A.H. Tulusan ; R. Adam ; M. Renhardt ; N. Atanasov ; D. Thyselius ; E. Merkle ; W. J a ·· ger ; N. Lang Discussion = 443
Recommendations and conclusions = 453
Appendix = 461
Index = 467
