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Foundations of environmental and occupational neurotoxicology

Foundations of environmental and occupational neurotoxicology

자료유형
단행본
개인저자
Valciukas, Jose A.
서명 / 저자사항
Foundations of environmental and occupational neurotoxicology / Jose A. Valciukas.
발행사항
New York :   Van Nostrand Reinhold,   c1991.  
형태사항
xx, 635 p. : ill. ; 27 cm.
ISBN
0442004303
서지주기
Includes bibliographical references and indexes.
일반주제명
Neurotoxicology. Industrial toxicology. Pollutants --Toxicology. Environmental Pollutants --toxicity. Nervous System --drug effects. Occupational Diseases --chemically induced.
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008 900521s1991 nyua b 001 0 eng c
010 ▼a 90012656
020 ▼a 0442004303
040 ▼a DNLM/DLC ▼c DLC ▼d NLM
049 1 ▼l 432002008
050 0 0 ▼a RC347.5 ▼b .V35 1991
082 0 0 ▼a 616.8 ▼2 20
090 ▼a 616.8 ▼b V141f
100 1 ▼a Valciukas, Jose A.
245 1 0 ▼a Foundations of environmental and occupational neurotoxicology / ▼c Jose A. Valciukas.
260 ▼a New York : ▼b Van Nostrand Reinhold, ▼c c1991.
300 ▼a xx, 635 p. : ▼b ill. ; ▼c 27 cm.
504 ▼a Includes bibliographical references and indexes.
650 0 ▼a Neurotoxicology.
650 0 ▼a Industrial toxicology.
650 0 ▼a Pollutants ▼x Toxicology.
650 2 ▼a Environmental Pollutants ▼x toxicity.
650 2 ▼a Nervous System ▼x drug effects.
650 2 ▼a Occupational Diseases ▼x chemically induced.

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No. 소장처 청구기호 등록번호 도서상태 반납예정일 예약 서비스
No. 1 소장처 의학도서관/보존서고4/ 청구기호 616.8 V141f 등록번호 432002008 도서상태 대출가능 반납예정일 예약 서비스 B M

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목차


CONTENTS
Preface = xv
Acknowledgments = xix
Introduction The History of Environmental and Occupational Neurotoxicology = 1
 Historical Background = 1
 Toxicology = 4
 Occupational Medicine = 5
 Conservation, Ecology, and The Environment = 9
 Epidemiology = 11
 Environmental Medicine = 11
 Consumerism = 12
 Psychology = 13
 The Birth of Behavioral Toxicology = 15
 Conclusions = 17
Part I FUNDAMENTALS AND TECHNIQUES = 25
 1 Main Components of the Nervous System = 27
  The Central Nervous System = 29
  The Peripheral Nervous System = 34
  The Autonomic Nervous System = 37
  The Neuroendocrine System = 37
  Conclusions = 39
 2 The Neurobiology of Neurotoxic Disease = 41
  Changing Views of Neurotoxic Illness = 41
  The Functional Organization of the Nervous System at the Cellular and Molecular Level = 45
  Neurotoxic Agents and Neurotransmission = 54
  Conclusion = 55
 3 The Clinical Neurological Examination = 58
  The Examination = 58
  Examination of Mental Status = 67
  Terms = 72
 4 Psychometric Techniques = 78
  Background = 78
  Representative Tests = 81
  Comprehensive Batteries for the Adult = 89
  Comprehensive Batteries for Children = 91
  Administration of Comprehensive Batteries = 92
  Experimental Psychometric Tests = 94
  Computer-Based Testing Procedures = 100
  Issues Related to Psychometric Testing = 102
  Conclusions = 105
 5 Electrophysiological Procedures = 110
  Electroencephalography = 111
  Evoked Potentials = 116
  Event-Related Potentials = 119
  Electromyography = 121
  Nerve Conduction Velocity Studies = 123
  Oculography = 128
  Other Techniques = 131
  Conclusions = 132
 6 Imaging of the Nervous System = 140
  X-Ray-Based Techniques = 140
  Echoencephalography = 141
  Isotope Scanning = 141
  Computer-Assisted Tomography = 143
  Positron Emission Tomography = 144
  Magnetic Resonance Imaging = 145
  Brain Electrical Activity = 147
  Infrared Imaging = 147
  Other Imaging Techniques = 148
  Conclusions = 148
Part II NEUROTOXIC CHEMICAL COMPOUNDS AND DRUGS = 151
 7 The Neurotoxic Environment = 153
  Definitions = 153
  Neurotoxic Agents in the Human Habitat = 155
  Classification of Neurotoxic Agents = 158
  Groupings = 160
  Conclusions = 164
 8 Classification of Neurotoxic Substances = 167
  Classification by Victim's Occupation = 167
  Classification by Neuropathological Changes to Gross Morphology = 168
  Classification by Neuropathological Alterations at the Cellular Level = 168
  Neuropharmacological Classification = 170
Part III PHARMACOLOGY, TOXICOLOGY, AND OCCUPATIONAL HEALTH = 173
 9 Absorption, Distribution, and Excretion of Neurotoxic Agents = 175
  Absorption = 175
  Distribution = 179
  Receptors = 182
  Excretion and Biotransformation = 183
  Blood Lead Levels as a Predictor of Neurotoxicity = 185
  Tolerance = 186
  Conclusions = 187
 10 Toxicology and the Environmental and Occupational Health Sciences = 191
  The Language of Toxicology = 191
  The Language of Environmental and Occupational Health = 194
 11 Occupational History = 197
  Information Contained in the Occupational History = 198
  Occupational Analysis = 199
  Conclusions = 199
Part IV METHODS OF DATA ANALYSIS = 203
 12 The Epidemiological Study of Neurotoxic Diseases = 205
  Epidemiology Defined = 205
  The Widening Perspectives of Environmental and Occupational Epidemiology = 205
  Research Plans and Study Designs = 208
  The Three Types of Study Design = 209
  Mixed Study Designs = 212
  Sources of Bias in Medical Field Surveys = 214
  Sampling = 215
  Conclusions = 218
 13 Surveys = 222
  Types of Surveys = 223
  The Research Protocol of a Medical Field Survey = 225
  Factors Affecting Response Rates to Surveys = 233
 14 Data Management = 241
  Data Collection and Classification = 241
  The Art and Science of Designing Computer-Compatible Forms = 244
  Computer Packages for Data Management = 248
  Graphic Representation of Data = 251
  Generation and Maintenance of Data Sets and Data Analysis = 254
  Issues Surrounding Data Management = 257
  Conclusion = 259
 15 Introduction to Data Analysis = 262
  Data Analysis and Statistics = 262
  Statistics as a Scientific Field = 265
  Statistics as a Scientific Method = 266
  Alternative Data-Analytical Strategies = 268
 16 Assessment of Human Exposure and Dose = 273
  Exposure Data in Occupational Epidemiology = 276
  Indices of Exposure = 280
 17 Assessment of Nervous System Functions in Groups = 285
  Data Analysis of Neurological Signs and Symptoms = 285
  Scoring and Data Analysis of Psychometric Tests = 290
  Data-Analytical Aspects of Electrophysiological Measures = 294
 18 Control of Demographic Confounders = 297
  Gender = 298
  Race and Ethnic Background = 299
  Education = 302
  Age = 303
  Demographic Variables and Their Interrelationships = 305
 19 Determining Toxic Causation = 308
  Clinical and Pharmacological Perspectives = 308
  The Case-Control Study = 310
  Contrasts = 311
  Correlational Analysis = 313
  Threshold Determinations = 319
  Multiregression Analysis = 320
  Larger Perspectives of Causation = 325
  Fallacies in the Search for Possible Toxic Causation = 330
Part V THE TARGETS OF NEUROTOXIOTY = 335
 20 Neurotoxic Agents and Brain Development = 337
  Development of the Nervous System = 337
  Neuroteratology = 339
  Pediatric Neurotoxicology = 343
  Representative Research = 344
  Conclusions = 348
 21 Levels of Consciousness = 359
  Consciousness = 359
  Testing Concentration = 361
  Vigilance and Vigilance Tests = 362
  Sleep and Wakefulness = 364
  Conclusions = 367
 22 Chemical Senses = 371
  Taste = 372
  Olfaction = 375
  Conclusions = 379
 23 Somatic Sensory Systems = 384
  Somatic Sensibility = 384
  Sensory Manifestations of Peripheral Neuropathies = 389
  Representative Research = 389
  Issues = 391
 24 The Vesribular System = 395
  Functional Organization = 395
  Examination of the Vestibular System = 398
  Representative Research = 399
 25 The Auditory System = 403
  Psychophysics = 404
  Assessment of Environmental Noise = 411
  The Functional Organization of the Auditory System = 413
  Assessment of Hearing Impairment = 416
  Conclusions = 420
 26 The Visual System = 422
  Functional Organization = 422
  Visual Perception = 431
  Experimental and Clinical Methods for Studying the Effects of Neurotoxic Agents = 435
  Sources of Information on Drugs and Substances That May Affect the Visual System = 438
  Illumination = 439
 27 Motor Behavior = 444
  Introduction to Motor Function = 444
  Perspectives on Motor Behavior = 445
  The Neural Basis of Motor Acts = 446
  Peripheral Neuropathies = 452
  Movement Disorders and Tremor = 455
  The Psychometric View of Motor Behavior = 457
  Subclinical Indicators of Motor Dysfunction: Reaction Time = 461
  The Motor Component of Speech = 463
 28 Motivation, Emotions, and Moods = 468
  The Autonomic Nervous System = 468
  Genetic Determinants of Behavior: Instincts and Drives = 470
  Emotions = 474
  Moods = 476
  Mood Alterations Produced by Environmental and Occupational Neurotoxic Agents = 481
 29 Learning and Memory = 488
  Learning and Memory as Processes = 488
  The Neural Basis of Learning = 490
  Learning and Memory Disorders in Humans = 493
  Assessment of Human Learning and Memory = 494
  Conclusions = 497
 30 Cognition = 499
  Intelligence = 499
  Language = 500
  Assessment of Cognition = 502
  Dementia = 503
  Neurotoxic Agents in the Environment and the Workplace as Etiological Factors for Organic Mental Disorders = 505
  Misinterpretation of Functions as Cognitive = 511
 31 Personality = 515
  Categorization of Personality Types and Traits = 515
  Psychotic Disorders and Personality Disorders = 519
  Effects of Neurotoxic Exposure on Personality = 522
  Issues Related to Personality Assessment = 523
Part VI CONFOUNDERS AND CURRENT ISSUES = 531
 32 Tht Question of Senile Dementia = 533
  Definitions of Aging = 533
  Biological Mechanisms of Aging = 534
  The Hypothesis That Aging May Be Toxically Induced = 536
  Conclusions = 539
 33 Alcoholism, Smoking, and Other Substance Abuse = 543
  Alcoholism = 543
  Cigarette Smoking and Nicotine = 549
  Coffee, Tea, and Herbal Teas = 552
  Other Substance Abuse = 552
  Drug Dependency = 555
  MPTP = 555
  Cultural and Community Standards and the Assessment of Substance Abuse = 556
  Conclusions = 556
 34 Mass Psychogenic Illness = 560
  Concepts of Hysteria = 560
  Current Perspectives on Mass Psychogenic Illness = 562
  The Epidemiology of Mass Psychogenic Illness = 564
 35 Neurotoxic Agents in Chemical Warfare = 568
  The Rise of Chemical Weapons = 568
  Neurotoxic Agents Used in Chemical Warfare = 570
  Current Debates and Moral Issues = 570
 36 Environmental and Occupational Neurotoxicology and the Changing Concept of "Quality of Life" = 572
  Quality of Life = 573
  Epilogue Environmental and Occupational Neurotoxicology as a Profession = 577
  The Clinical Evaluation = 577
  The Evaluation of Health Effects on Large Human Groups = 580
  Setting Standards and Assessing Risks = 581
  Performing Toxicological Experiments on Laboratory Animals = 584
  Observations of Nonhuman Species in Their Natural Habitats = 585
  Performing Human Studies Under Laboratory Conditions = 586
  Summing Up Research Results = 586
  Conclusions = 588
Name Index = 591
Subject Index = 595


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