CONTENTS
Preface = xi
Acknowledgments = xvii
Introduction : Problems and Questions = Xxi
Chapter = 1
A General Introduction to Communicative Symbols = 1
The Functionalist Paradigm = 1
Functionlist Fallacy and Muddled Metaphor = 2
Relationship of Hypothetical Hardware and Software = 4
Structure and Function : Dynamics of Neural Architecture = 7
Comnunication, Growth, and Altered Architecture : Emerging Unity = 8
The Connectionist Program : A Response to Functionalism = 10
Reductionist Programs = 11
Structure and Function in Brain and Mind = 13
Overview = 14
Communicative Symbols in the Nervous System = 15
Temporal Dimension and Communicative Symbols = 18
Molecular Structures and Neural Systems Organization = 19
Mental Function and Cell Biology = 21
Chapter = 2
A General Introduction to a Specific Synapse : Definitions and Explanations = 23
Biosynthesis = 25
Storage = 29
Release = 29
Catecholamine Receptors = 30
Presynaptic Receptors : Unconventional Communication = 33
Termination of Catecholamine Action = 34
Catecholamine Phenotypic Expression = 35
Coexpression of Catecholaminergic and Peptidergic Phenotypes = 36
Long-Term Synaptic Change = 37
Chapter = 3
The Molecules : Transmitters as Prototypes = 43
Symobolic Function is System Specific = 45
Properties of Molecular Symbols = 46
Communicative Functions = 52
Communicative Symbols and Transducer Molecules = 55
Enzyme Activation = 56
Enzyme Induction = 57
Chapter = 4
From Molecule to Brain Function and Behavior = 61
Molecular Symbols and The Behavior-Motor Interface = 68
Form and Content In Behavior = 72
Chapter = 5
Combinatorial Strategies at the Synapse = 77
Electrochemical Coding = 79
Combinatorial Transmitter Storage = 85
Differential Transmitter Expression and Metabolism = 86
Combinatorial Systems in the Adrenal Medulla Model System = 92
Combinatorial Potential in the Brain : Mechanistic Considerations = 95
Interpretations and Implications = 96
Chapter = 6
Molecules and Modularity of Brain Function = 101
Arginine Vasopressin : A Simple Model Molecule = 102
Polyproteins and Opiate Peptides : POMC = 106
Other Opiate Polyproteins = 107
Genomic Organization of Polyproteins = 109
The Polyprotein Module In Invertebrates = 113
Some General Considerations = 115
Chapter = 7
Molecules and Systems : Trophic Interactions = 117
Ngf, Peripheral Systems, and Function = 119
Ngf and Systems Relations = 121
Characteristics of the Ngf Molecule = 122
Trophic Interactions in the Brain = 123
Ngf, Acetylcholine, and Memory = 128
Ngf and Other Brain Systems = 129
Other Trophic Molecules in the Brain = 129
Chapter = 8
Modularity of Brain Function : Psychologic, Anatomic, and Molecular Domains = 133
Modularity in Split-Brain Patients = 134
Modularity and Disconnection Syndromes = 138
Disconnection and Modularity in Parkinson'S Disease = 141
Modularity in Subhuman Primates : Some Molar-Molecular Relationships = 142
Conclusions = 147
Chapter = 9
Symbols and Regulatory Biology = 149
Metazoan Effector Molecules and Neural Function = 151
Complex Metazoan Forms = 152
A Parazoan Nervous System? = 153
Coelenterates and the Conventional Nervous System = 156
Primitive Systems : Growth and Trophic Function = 157
Some Implications = 159
Chapter = 10
Symbols, Self, and Subjectivity = 161
Psychologic Function = 162
A Profusion of Levels = 164
Some Implications = 166
Self and Subjectibity = 167
The Frontal Lobes and the Principle Of Reciprocity = 172
Frontal-Dopaminergic Connections = 175
Interactions Among Individuals = 180
Glossary = 183
Bibliography = 195
Index = 213
